braf after zelboraf
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braf after zelboraf

› Forums › General Melanoma Community › braf after zelboraf

  • Post
    • November 30, 2011 at 7:42 pm
    boot2aboot
    Participant

    Could anyone on this forum tell me is Mek trial is effective after zelboraf?

    I have read that braf/mek combos are effective treatments.

    Can people still participate in Braf/Mek trials after taking zelboraf?

    Could anyone on this forum tell me is Mek trial is effective after zelboraf?

    I have read that braf/mek combos are effective treatments.

    Can people still participate in Braf/Mek trials after taking zelboraf?

Viewing 2 reply threads
  • Replies
      • December 1, 2011 at 3:29 am
      deardad
      Participant

      Hi I am also interesting in answers on this topic. My dad is on Zelboraf month 3 and we feel like sitting ducks. The onocologist did mention that we could try MEK next, but I don't know why they didn't just give him the combination in the first place? What is next after Zelboraf or is that the last card? 

      Nahmi from Melbourne

      • December 1, 2011 at 3:29 am
      deardad
      Participant

      Hi I am also interesting in answers on this topic. My dad is on Zelboraf month 3 and we feel like sitting ducks. The onocologist did mention that we could try MEK next, but I don't know why they didn't just give him the combination in the first place? What is next after Zelboraf or is that the last card? 

      Nahmi from Melbourne

        • December 1, 2011 at 11:35 am
        FormerCaregiver
        Participant

        Nahmi, here is a link to the MEK trials in Australia:
        http://www.clinicaltrials.gov/ct2/results?term=melanoma+MEK+Inhibitor&recr=Open&cntry1=PA%3AAU

        Your dad's oncologist is probably hesitant to recommend any new drug that hasn't been
        approved by the TGA. As you may know, Yervoy has recently been approved here and the
        oncologist should be able to tell you how your dad could have access to it.

        Some other viable options could be IL-2 (interleukin-2), TIL treatment (adoptive cell
        therapy) and Anti PD-1 treatment. However, these may be unavailable locally and some may
        only be accessed through clinical trials.

        Therefore, it is important to make definite plans for the next treatment if the current one
        becomes ineffective.

        Hope this helps.

        Frank from Australia

        • December 1, 2011 at 11:35 am
        FormerCaregiver
        Participant

        Nahmi, here is a link to the MEK trials in Australia:
        http://www.clinicaltrials.gov/ct2/results?term=melanoma+MEK+Inhibitor&recr=Open&cntry1=PA%3AAU

        Your dad's oncologist is probably hesitant to recommend any new drug that hasn't been
        approved by the TGA. As you may know, Yervoy has recently been approved here and the
        oncologist should be able to tell you how your dad could have access to it.

        Some other viable options could be IL-2 (interleukin-2), TIL treatment (adoptive cell
        therapy) and Anti PD-1 treatment. However, these may be unavailable locally and some may
        only be accessed through clinical trials.

        Therefore, it is important to make definite plans for the next treatment if the current one
        becomes ineffective.

        Hope this helps.

        Frank from Australia

        • December 1, 2011 at 11:35 am
        FormerCaregiver
        Participant

        Nahmi, here is a link to the MEK trials in Australia:
        http://www.clinicaltrials.gov/ct2/results?term=melanoma+MEK+Inhibitor&recr=Open&cntry1=PA%3AAU

        Your dad's oncologist is probably hesitant to recommend any new drug that hasn't been
        approved by the TGA. As you may know, Yervoy has recently been approved here and the
        oncologist should be able to tell you how your dad could have access to it.

        Some other viable options could be IL-2 (interleukin-2), TIL treatment (adoptive cell
        therapy) and Anti PD-1 treatment. However, these may be unavailable locally and some may
        only be accessed through clinical trials.

        Therefore, it is important to make definite plans for the next treatment if the current one
        becomes ineffective.

        Hope this helps.

        Frank from Australia

        • December 1, 2011 at 9:33 pm
        deardad
        Participant

        Thanks Frank for posting that, not sure where to go next really. My parents don't want to even talk really about the next treatment until the braf fails. Very frustrating.

        Nahmi from Melbourne

        • December 2, 2011 at 7:16 am
        FormerCaregiver
        Participant

        Nahmi, I think that you will need to research the treatments for your dad. This will need a lot of work, but I think that it is necessary.

        The Net makes it easier to find out where various treatments are available. However, you will also have to contact various treatment centres by phone and/or email to get more info.

        You would also need to ring his oncologist to talk about this. A second opinion could also be an idea.

        As you might know, I am also located in Melbourne. However, I don't know if that helps at all.

        Take care

        Frank from Australia

        • December 2, 2011 at 8:20 am
        deardad
        Participant

        Ok thanks, I will do some research. Im keen to find out about Antipd1 trial if there are any in Australia. I know Jim Stynes who being treated by my dad's oncologist is on this drug. From what I understand TIL requires you to be under the age of 60. I will ask the oncologist about this in 2 weeks. Thanks again.

        Nahmi

        • December 2, 2011 at 8:20 am
        deardad
        Participant

        Ok thanks, I will do some research. Im keen to find out about Antipd1 trial if there are any in Australia. I know Jim Stynes who being treated by my dad's oncologist is on this drug. From what I understand TIL requires you to be under the age of 60. I will ask the oncologist about this in 2 weeks. Thanks again.

        Nahmi

        • December 2, 2011 at 8:20 am
        deardad
        Participant

        Ok thanks, I will do some research. Im keen to find out about Antipd1 trial if there are any in Australia. I know Jim Stynes who being treated by my dad's oncologist is on this drug. From what I understand TIL requires you to be under the age of 60. I will ask the oncologist about this in 2 weeks. Thanks again.

        Nahmi

        • December 2, 2011 at 7:16 am
        FormerCaregiver
        Participant

        Nahmi, I think that you will need to research the treatments for your dad. This will need a lot of work, but I think that it is necessary.

        The Net makes it easier to find out where various treatments are available. However, you will also have to contact various treatment centres by phone and/or email to get more info.

        You would also need to ring his oncologist to talk about this. A second opinion could also be an idea.

        As you might know, I am also located in Melbourne. However, I don't know if that helps at all.

        Take care

        Frank from Australia

        • December 2, 2011 at 7:16 am
        FormerCaregiver
        Participant

        Nahmi, I think that you will need to research the treatments for your dad. This will need a lot of work, but I think that it is necessary.

        The Net makes it easier to find out where various treatments are available. However, you will also have to contact various treatment centres by phone and/or email to get more info.

        You would also need to ring his oncologist to talk about this. A second opinion could also be an idea.

        As you might know, I am also located in Melbourne. However, I don't know if that helps at all.

        Take care

        Frank from Australia

        • December 1, 2011 at 9:33 pm
        deardad
        Participant

        Thanks Frank for posting that, not sure where to go next really. My parents don't want to even talk really about the next treatment until the braf fails. Very frustrating.

        Nahmi from Melbourne

        • December 1, 2011 at 9:33 pm
        deardad
        Participant

        Thanks Frank for posting that, not sure where to go next really. My parents don't want to even talk really about the next treatment until the braf fails. Very frustrating.

        Nahmi from Melbourne

      • December 1, 2011 at 3:29 am
      deardad
      Participant

      Hi I am also interesting in answers on this topic. My dad is on Zelboraf month 3 and we feel like sitting ducks. The onocologist did mention that we could try MEK next, but I don't know why they didn't just give him the combination in the first place? What is next after Zelboraf or is that the last card? 

      Nahmi from Melbourne

Viewing 2 reply threads
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