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BMS Ipi & Nivo combo trial — 13wk scan update
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BMS Ipi & Nivo combo trial — 13wk scan update

› Forums › General Melanoma Community › BMS Ipi & Nivo combo trial — 13wk scan update

  • Post
    • November 17, 2013 at 2:26 pm
    UrsulaZ
    Participant

      Hello —

      I have stage IV melanoma with several abdominal mets, and am travelling to Memorial-Sloan-Kettering in NY to be part of this trial:

      CA209-004, A Phase Ib, Open-Label, Multicenter Dose-Escalation Study of MDX-1106 (Nivolumab; BMS-936558) in Combination with Ipilimumab (BMS-734016) in Subjects with Unresectable Stage III or Stage IV Malignant Melanoma

      I've received my first four doses (the ipi & nivo in combination), and am now going to get the nivolumab alone every two weeks. 

      I recently had my first scans, and there were no new mets, and an overall reduction in the existing lesions of 62%. (the largest was about 7 x 5 cm, and that's shrunk by half). 

      They will scan again in mid-December.

      I'm on Prednisone now for some Ipi-induced colitis, but that's OK. 

      Cautiously relieved and hopeful that others can also benefit from the new research in the area. 

      -Ursula

    Viewing 8 reply threads
    • Replies
        • November 18, 2013 at 1:54 am
        Tina D
        Participant

          That is really good news!

          Tina

          • November 18, 2013 at 1:54 am
          Tina D
          Participant

            That is really good news!

            Tina

            • November 18, 2013 at 1:54 am
            Tina D
            Participant

              That is really good news!

              Tina

              • November 18, 2013 at 2:04 am
              BrianP
              Participant

                Ursula,

                That is fantastic news! So happy to hear you are a responder.

                I got pretty good news on my first scans as well. I'm in the BMS sequential trial of IPI/Nivo.  I completed my 12 week cycle of the six infusions of Nivo a few weeks ago and the scans after that showed no new mets and shrinkage in the two mets I have.  One went from 3.6 x 2.6 (axial plane) x 2.6 cm (CC) down to  2.8 x 2.2 (axial plane) x 2.1 cm (CC) and the other went from 18 x 13 (trv) x 18mm (CC) to 16 x 10 (trv) x mm.  The way they calculated the % of shrinkage was a little confusing and I can't remember the exact figures but all I know is that they were both smaller and smaller is better!

                Had my first IPI infusion a couple weeks ago.  So far so good.  The only real side effect I seemed to experience on the Nivo was stiffness in my hands which is continuing a little now into the IPI.  Since starting the IPI I probably have a little less energy but it's not really impacting me that much.  I just fall asleep quicker at night 🙂

                Hope the good news continues for you and I hope the colitis is under control for you.

                Brian

                  • November 18, 2013 at 12:49 pm
                  Maureen038
                  Participant

                    Ursula and Brian,

                      I am so happy for both of you on your results!! That's such wonderful news! I am hoping and praying that my husband sees results too. He won't have scans until the beginning of January. He is on the exact trial as Ursula and has his third infusion next week. He just started having some fatigue and nausea. You will both be in my prayers that you continue to get great results. Take care.

                    Maureen

                    • November 18, 2013 at 3:17 pm
                    NYKaren
                    Participant

                      Hi guys, great news to hear from you both!

                      Ursula, I had the same Ipi-induced colitis…had to have 2 (separate, about a month apart) doses of Remicade to resolve it.  It was like a miracle drug for me!  I had to call in to Dr. Wolchok's office every day to tell them about my bowel movements.    I took Budesonide, some Immodium and Prednisone just to get out of the house!   

                      Continued good scans, you are both in  my prayers.

                       

                      Karen

                      • November 19, 2013 at 1:12 am
                      UrsulaZ
                      Participant

                        Brian, I was thinking about you the other day — I'm so glad that you've had response as well.

                        Thank you, Maureen & Karen!

                        I feel as though I have a bit of time to breathe and go tobogganing with my kids. Small pleasures. (well; huge pleasures, really). 

                        • November 19, 2013 at 1:12 am
                        UrsulaZ
                        Participant

                          Brian, I was thinking about you the other day — I'm so glad that you've had response as well.

                          Thank you, Maureen & Karen!

                          I feel as though I have a bit of time to breathe and go tobogganing with my kids. Small pleasures. (well; huge pleasures, really). 

                          • November 19, 2013 at 1:12 am
                          UrsulaZ
                          Participant

                            Brian, I was thinking about you the other day — I'm so glad that you've had response as well.

                            Thank you, Maureen & Karen!

                            I feel as though I have a bit of time to breathe and go tobogganing with my kids. Small pleasures. (well; huge pleasures, really). 

                            • November 18, 2013 at 3:17 pm
                            NYKaren
                            Participant

                              Hi guys, great news to hear from you both!

                              Ursula, I had the same Ipi-induced colitis…had to have 2 (separate, about a month apart) doses of Remicade to resolve it.  It was like a miracle drug for me!  I had to call in to Dr. Wolchok's office every day to tell them about my bowel movements.    I took Budesonide, some Immodium and Prednisone just to get out of the house!   

                              Continued good scans, you are both in  my prayers.

                               

                              Karen

                              • November 18, 2013 at 3:17 pm
                              NYKaren
                              Participant

                                Hi guys, great news to hear from you both!

                                Ursula, I had the same Ipi-induced colitis…had to have 2 (separate, about a month apart) doses of Remicade to resolve it.  It was like a miracle drug for me!  I had to call in to Dr. Wolchok's office every day to tell them about my bowel movements.    I took Budesonide, some Immodium and Prednisone just to get out of the house!   

                                Continued good scans, you are both in  my prayers.

                                 

                                Karen

                                • November 18, 2013 at 12:49 pm
                                Maureen038
                                Participant

                                  Ursula and Brian,

                                    I am so happy for both of you on your results!! That's such wonderful news! I am hoping and praying that my husband sees results too. He won't have scans until the beginning of January. He is on the exact trial as Ursula and has his third infusion next week. He just started having some fatigue and nausea. You will both be in my prayers that you continue to get great results. Take care.

                                  Maureen

                                  • November 18, 2013 at 12:49 pm
                                  Maureen038
                                  Participant

                                    Ursula and Brian,

                                      I am so happy for both of you on your results!! That's such wonderful news! I am hoping and praying that my husband sees results too. He won't have scans until the beginning of January. He is on the exact trial as Ursula and has his third infusion next week. He just started having some fatigue and nausea. You will both be in my prayers that you continue to get great results. Take care.

                                    Maureen

                                  • November 18, 2013 at 2:04 am
                                  BrianP
                                  Participant

                                    Ursula,

                                    That is fantastic news! So happy to hear you are a responder.

                                    I got pretty good news on my first scans as well. I'm in the BMS sequential trial of IPI/Nivo.  I completed my 12 week cycle of the six infusions of Nivo a few weeks ago and the scans after that showed no new mets and shrinkage in the two mets I have.  One went from 3.6 x 2.6 (axial plane) x 2.6 cm (CC) down to  2.8 x 2.2 (axial plane) x 2.1 cm (CC) and the other went from 18 x 13 (trv) x 18mm (CC) to 16 x 10 (trv) x mm.  The way they calculated the % of shrinkage was a little confusing and I can't remember the exact figures but all I know is that they were both smaller and smaller is better!

                                    Had my first IPI infusion a couple weeks ago.  So far so good.  The only real side effect I seemed to experience on the Nivo was stiffness in my hands which is continuing a little now into the IPI.  Since starting the IPI I probably have a little less energy but it's not really impacting me that much.  I just fall asleep quicker at night 🙂

                                    Hope the good news continues for you and I hope the colitis is under control for you.

                                    Brian

                                    • November 18, 2013 at 2:04 am
                                    BrianP
                                    Participant

                                      Ursula,

                                      That is fantastic news! So happy to hear you are a responder.

                                      I got pretty good news on my first scans as well. I'm in the BMS sequential trial of IPI/Nivo.  I completed my 12 week cycle of the six infusions of Nivo a few weeks ago and the scans after that showed no new mets and shrinkage in the two mets I have.  One went from 3.6 x 2.6 (axial plane) x 2.6 cm (CC) down to  2.8 x 2.2 (axial plane) x 2.1 cm (CC) and the other went from 18 x 13 (trv) x 18mm (CC) to 16 x 10 (trv) x mm.  The way they calculated the % of shrinkage was a little confusing and I can't remember the exact figures but all I know is that they were both smaller and smaller is better!

                                      Had my first IPI infusion a couple weeks ago.  So far so good.  The only real side effect I seemed to experience on the Nivo was stiffness in my hands which is continuing a little now into the IPI.  Since starting the IPI I probably have a little less energy but it's not really impacting me that much.  I just fall asleep quicker at night 🙂

                                      Hope the good news continues for you and I hope the colitis is under control for you.

                                      Brian

                                      • January 6, 2014 at 10:24 pm
                                      Globetrotter
                                      Participant

                                        hi ursula et al .. happy new year!! i was wondering how your ipi/nivo treatment was coming along and what side effects u have been experiencing … wishing you all a healthy 2014!!!

                                        • January 6, 2014 at 10:24 pm
                                        Globetrotter
                                        Participant

                                          hi ursula et al .. happy new year!! i was wondering how your ipi/nivo treatment was coming along and what side effects u have been experiencing … wishing you all a healthy 2014!!!

                                          • January 6, 2014 at 10:24 pm
                                          Globetrotter
                                          Participant

                                            hi ursula et al .. happy new year!! i was wondering how your ipi/nivo treatment was coming along and what side effects u have been experiencing … wishing you all a healthy 2014!!!

                                        Viewing 8 reply threads
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