Bell’s Palsy – side effect of combo ipi/nivo treatment?

I have had 4 doses of the combo, 4 doses of nivo and friday went back to combo. I have not had Bales Palsey but have had salava gland issues and messed up taste issues that both over time went away.

I have had 4 doses of the combo, 4 doses of nivo and friday went back to combo. I have not had Bales Palsey but have had salava gland issues and messed up taste issues that both over time went away.

I have had 4 doses of the combo, 4 doses of nivo and friday went back to combo. I have not had Bales Palsey but have had salava gland issues and messed up taste issues that both over time went away.

Hi Linda

It is possible that this is related tothe combo and caused by an inflammation of the nerve. It runs in my sisters family- her father in law had it in his 50's and her son had a short lived episode this autumn. The facial nerve has little space on route to the face and it it becomes inflamed the nerve can be pinched by the bony bhard structures leading to the condition. Treatment- high dose steroids- just the same as for the majority of other immune related adverse events. Think itis probably pretty unusual compared to say peripheral neuropathy- but ipi nivo does cause neurological side effects and I would bet on the combo as your likely cause.

see this – page 9/14

http://download.springer.com/static/pdf/82/art%253A10.1186%252Fs40661-016-0033-6.pdf?originUrl=http%3A%2F%2Fgynoncrp.biomedcentral.com%2Farticle%2F10.1186%2Fs40661-016-0033-6&token2=exp=1483218820~acl=%2Fstatic%2Fpdf%2F82%2Fart%25253A10.1186%25252Fs40661-016-0033-6.pdf*~hmac=95d9a1b3299ed7e87055d0e6444d8cc8a1d19dfe7f7cd6c49b324b4213c86e5e

Bell's palsy reported as IRAE – of CTLA4 drugs ie ipi….Link discusses ovarian cancer- but it is the same drug– so place your bets,,,

Best of luck with your treatment

Deb

Hi Linda

It is possible that this is related tothe combo and caused by an inflammation of the nerve. It runs in my sisters family- her father in law had it in his 50's and her son had a short lived episode this autumn. The facial nerve has little space on route to the face and it it becomes inflamed the nerve can be pinched by the bony bhard structures leading to the condition. Treatment- high dose steroids- just the same as for the majority of other immune related adverse events. Think itis probably pretty unusual compared to say peripheral neuropathy- but ipi nivo does cause neurological side effects and I would bet on the combo as your likely cause.

see this – page 9/14

http://download.springer.com/static/pdf/82/art%253A10.1186%252Fs40661-016-0033-6.pdf?originUrl=http%3A%2F%2Fgynoncrp.biomedcentral.com%2Farticle%2F10.1186%2Fs40661-016-0033-6&token2=exp=1483218820~acl=%2Fstatic%2Fpdf%2F82%2Fart%25253A10.1186%25252Fs40661-016-0033-6.pdf*~hmac=95d9a1b3299ed7e87055d0e6444d8cc8a1d19dfe7f7cd6c49b324b4213c86e5e

Bell's palsy reported as IRAE – of CTLA4 drugs ie ipi….Link discusses ovarian cancer- but it is the same drug– so place your bets,,,

Best of luck with your treatment

Deb

Hi Linda

It is possible that this is related tothe combo and caused by an inflammation of the nerve. It runs in my sisters family- her father in law had it in his 50's and her son had a short lived episode this autumn. The facial nerve has little space on route to the face and it it becomes inflamed the nerve can be pinched by the bony bhard structures leading to the condition. Treatment- high dose steroids- just the same as for the majority of other immune related adverse events. Think itis probably pretty unusual compared to say peripheral neuropathy- but ipi nivo does cause neurological side effects and I would bet on the combo as your likely cause.

see this – page 9/14

http://download.springer.com/static/pdf/82/art%253A10.1186%252Fs40661-016-0033-6.pdf?originUrl=http%3A%2F%2Fgynoncrp.biomedcentral.com%2Farticle%2F10.1186%2Fs40661-016-0033-6&token2=exp=1483218820~acl=%2Fstatic%2Fpdf%2F82%2Fart%25253A10.1186%25252Fs40661-016-0033-6.pdf*~hmac=95d9a1b3299ed7e87055d0e6444d8cc8a1d19dfe7f7cd6c49b324b4213c86e5e

Bell's palsy reported as IRAE – of CTLA4 drugs ie ipi….Link discusses ovarian cancer- but it is the same drug– so place your bets,,,

Best of luck with your treatment

Deb