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Just found your message, Anni. Not sure if you meant to mark it private. Not sure how to respond “privately” so I hope this is okay. As my link in the report above notes – intrathecal – the delivery of medications directly into the spinal fluid space, often via a port – administration of various medications (often immunotherapy like ipi and/or nivo) have had some success in LMD. Needless to say it is a complicated process, so it is not readily available everywhere. However, there is this report from 2021 in the UK noting the administration of methotrexate via IT followed by systemic therapy with good result – Durable complete remission of leptomeningeal melanoma by intrathecal methotrexate maintained with systemic ipilimumab
So, I would be calling Future Medicine in London, to see if I could get additional info.
Thank you again Celeste, I will seek more information.
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