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Anyone with a high Mitotic rate
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Anyone with a high Mitotic rate

› Forums › General Melanoma Community › Anyone with a high Mitotic rate

  • Post
    • August 4, 2014 at 9:19 pm
    Kdw2012
    Participant

      Do you know if having a high mitotic rate plays a factor in recurrence or aggressiveness of tumors?

      What has been your experience?  

      My melanomas mitotic rate was 15 but It was also ulcerated

      thank you

    Viewing 8 reply threads
    • Replies
        • August 4, 2014 at 9:51 pm
        MissyT
        Participant

          I was JUST starting to post a question about mitotic rate when yours popped up.  

          My husband was diagnosed 3A in May 2014.  He had 2 positive SLN and had full disection, removing 42 lymph nodes under his right arm, all negative.  His primary was on his chest, 1.9mm depth, mitotic rate of 10. It has been hard to know what the mitotic rate indicates prognosis or reoccurance-wise, there is no resource that really explains how much worse a higher mitotic rate is than a lower one.

          Ben's oncologist did say that anything over a 1 was a concern to him.  From what I have been able to find, it seems that 0 is ideal, <1 is not really bad, but anything 1 or greater was bad.  And it didn't seem that a rate of 2 versus a rate a 15 had much difference in terms of prognosis.  So if you are 1 or greater, they just consider it "high mitotic rate.

          I'd love more advice on this, however.  It does seem quite vague.

          We are in the process of deciding whether to do ITF or just watch & wait.  Did you do any treatments?

            • August 4, 2014 at 10:00 pm
            Kdw2012
            Participant

              I think anything 10-20 is considered high. Here is an article from 2011

              To our knowledge, this is the first large multi-institutional study that has examined the survival impact of mitotic rate compared with other clinical and pathologic features in patients with AJCC stages I and II melanoma. Mitotic rate, a quantitative measure of melanoma proliferation, was the most important predictor of survival outcome after accounting for primary tumor thickness. The presence of many mitotic figures in any primary tumor indicates that cells are actively dividing and usually implies that such tumors are likely to grow more rapidly and may metastasize earlier than those with little or no mitotic activity. Our study confirms that, in patients with a localized primary melanoma, a high tumor mitotic rate reflects a more aggressive tumor that is associated with a worse survival outcome; conversely, a low mitotic rate is associated with a better outcome.

              This is from the Journal of Oncology

              I was diagnosed in July of 2012 and had a recurrence in May 2014

              I was wondering what anyone else's experience might be.

              I am waiting for insurance approval to do Yervoy in the next couple weeks, they want to do another PET scan first.

              • August 4, 2014 at 10:00 pm
              Kdw2012
              Participant

                I think anything 10-20 is considered high. Here is an article from 2011

                To our knowledge, this is the first large multi-institutional study that has examined the survival impact of mitotic rate compared with other clinical and pathologic features in patients with AJCC stages I and II melanoma. Mitotic rate, a quantitative measure of melanoma proliferation, was the most important predictor of survival outcome after accounting for primary tumor thickness. The presence of many mitotic figures in any primary tumor indicates that cells are actively dividing and usually implies that such tumors are likely to grow more rapidly and may metastasize earlier than those with little or no mitotic activity. Our study confirms that, in patients with a localized primary melanoma, a high tumor mitotic rate reflects a more aggressive tumor that is associated with a worse survival outcome; conversely, a low mitotic rate is associated with a better outcome.

                This is from the Journal of Oncology

                I was diagnosed in July of 2012 and had a recurrence in May 2014

                I was wondering what anyone else's experience might be.

                I am waiting for insurance approval to do Yervoy in the next couple weeks, they want to do another PET scan first.

                • August 4, 2014 at 10:00 pm
                Kdw2012
                Participant

                  I think anything 10-20 is considered high. Here is an article from 2011

                  To our knowledge, this is the first large multi-institutional study that has examined the survival impact of mitotic rate compared with other clinical and pathologic features in patients with AJCC stages I and II melanoma. Mitotic rate, a quantitative measure of melanoma proliferation, was the most important predictor of survival outcome after accounting for primary tumor thickness. The presence of many mitotic figures in any primary tumor indicates that cells are actively dividing and usually implies that such tumors are likely to grow more rapidly and may metastasize earlier than those with little or no mitotic activity. Our study confirms that, in patients with a localized primary melanoma, a high tumor mitotic rate reflects a more aggressive tumor that is associated with a worse survival outcome; conversely, a low mitotic rate is associated with a better outcome.

                  This is from the Journal of Oncology

                  I was diagnosed in July of 2012 and had a recurrence in May 2014

                  I was wondering what anyone else's experience might be.

                  I am waiting for insurance approval to do Yervoy in the next couple weeks, they want to do another PET scan first.

                • August 4, 2014 at 9:51 pm
                MissyT
                Participant

                  I was JUST starting to post a question about mitotic rate when yours popped up.  

                  My husband was diagnosed 3A in May 2014.  He had 2 positive SLN and had full disection, removing 42 lymph nodes under his right arm, all negative.  His primary was on his chest, 1.9mm depth, mitotic rate of 10. It has been hard to know what the mitotic rate indicates prognosis or reoccurance-wise, there is no resource that really explains how much worse a higher mitotic rate is than a lower one.

                  Ben's oncologist did say that anything over a 1 was a concern to him.  From what I have been able to find, it seems that 0 is ideal, <1 is not really bad, but anything 1 or greater was bad.  And it didn't seem that a rate of 2 versus a rate a 15 had much difference in terms of prognosis.  So if you are 1 or greater, they just consider it "high mitotic rate.

                  I'd love more advice on this, however.  It does seem quite vague.

                  We are in the process of deciding whether to do ITF or just watch & wait.  Did you do any treatments?

                  • August 4, 2014 at 9:51 pm
                  MissyT
                  Participant

                    I was JUST starting to post a question about mitotic rate when yours popped up.  

                    My husband was diagnosed 3A in May 2014.  He had 2 positive SLN and had full disection, removing 42 lymph nodes under his right arm, all negative.  His primary was on his chest, 1.9mm depth, mitotic rate of 10. It has been hard to know what the mitotic rate indicates prognosis or reoccurance-wise, there is no resource that really explains how much worse a higher mitotic rate is than a lower one.

                    Ben's oncologist did say that anything over a 1 was a concern to him.  From what I have been able to find, it seems that 0 is ideal, <1 is not really bad, but anything 1 or greater was bad.  And it didn't seem that a rate of 2 versus a rate a 15 had much difference in terms of prognosis.  So if you are 1 or greater, they just consider it "high mitotic rate.

                    I'd love more advice on this, however.  It does seem quite vague.

                    We are in the process of deciding whether to do ITF or just watch & wait.  Did you do any treatments?

                    • August 5, 2014 at 1:19 am
                    washoegal
                    Participant

                      The mitotic rate definitely plays a role in the aggressiveness of the tumor as it defines the rate of spread of the tumor.  My rate was also 15.  It is measured between 0 and 20.  As far as recurrence, I don't know if anyone really understand the mechanism for recurrence, assuming you have been NED for a while. 

                      Mary

                        • August 5, 2014 at 10:26 pm
                        Kdw2012
                        Participant

                          With my recurrence to my lymph node it seemed particularly aggressive it grew in about two weeks to the size of a golf ball. I was searching for information in regards to tumor growth rate and mitotic rate to see if there is any proven correlation or what peoples experiences are.

                          Best wishes to all

                          Kim

                          • August 5, 2014 at 10:26 pm
                          Kdw2012
                          Participant

                            With my recurrence to my lymph node it seemed particularly aggressive it grew in about two weeks to the size of a golf ball. I was searching for information in regards to tumor growth rate and mitotic rate to see if there is any proven correlation or what peoples experiences are.

                            Best wishes to all

                            Kim

                            • August 5, 2014 at 10:26 pm
                            Kdw2012
                            Participant

                              With my recurrence to my lymph node it seemed particularly aggressive it grew in about two weeks to the size of a golf ball. I was searching for information in regards to tumor growth rate and mitotic rate to see if there is any proven correlation or what peoples experiences are.

                              Best wishes to all

                              Kim

                            • August 5, 2014 at 1:19 am
                            washoegal
                            Participant

                              The mitotic rate definitely plays a role in the aggressiveness of the tumor as it defines the rate of spread of the tumor.  My rate was also 15.  It is measured between 0 and 20.  As far as recurrence, I don't know if anyone really understand the mechanism for recurrence, assuming you have been NED for a while. 

                              Mary

                              • August 5, 2014 at 1:19 am
                              washoegal
                              Participant

                                The mitotic rate definitely plays a role in the aggressiveness of the tumor as it defines the rate of spread of the tumor.  My rate was also 15.  It is measured between 0 and 20.  As far as recurrence, I don't know if anyone really understand the mechanism for recurrence, assuming you have been NED for a while. 

                                Mary

                                • August 7, 2014 at 12:35 am
                                Thandster
                                Participant

                                  My specialist said that it is predictive relating to lymph node involvement – meaning the higher the mitotic rate the more likely the slnb will be positive – but that it has no long term prognostic value. 

                                  • August 7, 2014 at 12:35 am
                                  Thandster
                                  Participant

                                    My specialist said that it is predictive relating to lymph node involvement – meaning the higher the mitotic rate the more likely the slnb will be positive – but that it has no long term prognostic value. 

                                    • August 7, 2014 at 12:35 am
                                    Thandster
                                    Participant

                                      My specialist said that it is predictive relating to lymph node involvement – meaning the higher the mitotic rate the more likely the slnb will be positive – but that it has no long term prognostic value. 

                                  Viewing 8 reply threads
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