anyone on this study????
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anyone on this study????

› Forums › General Melanoma Community › anyone on this study????

  • Post
    • August 24, 2011 at 4:52 pm
    boot2aboot
    Participant

     

     

    Peptides and Montanide ISA 51 VG with Escalating Doses of anti-PD-1 Antibody BMS-936558 for Patients with Unresectable Stages III/IV Melanoma….it was recommended to me but i still can;'t figure out my HLA type…i got test results back and can't make any sense out of it…anyway, please let me know if anyone on this board is on this study and how they are doing…thank you

    boots

     

Viewing 7 reply threads
  • Replies
      • August 24, 2011 at 6:58 pm
      dian in spokane
      Participant

      post those results. Use a separate thread so you can put in the subject line 'need help with HLA test results. There are some folks here who are great with that stuff.

      I don't know your study, though it sounds familiar…good luck!

      dian in spokane

      • August 24, 2011 at 6:58 pm
      dian in spokane
      Participant

      post those results. Use a separate thread so you can put in the subject line 'need help with HLA test results. There are some folks here who are great with that stuff.

      I don't know your study, though it sounds familiar…good luck!

      dian in spokane

      • August 24, 2011 at 8:35 pm
      shellebrownies
      Participant

      I believe that lynnluckeroth@hotmail.com is on an AntiPD-1 trial (but not this exact one, I don't think) and is doing quite well (NED I think?). Perhaps you can contact her with some questions… : )

      Here's hoping you find a new treatment soon!

      Michelle, wife of Don

       

      • August 24, 2011 at 8:35 pm
      shellebrownies
      Participant

      I believe that lynnluckeroth@hotmail.com is on an AntiPD-1 trial (but not this exact one, I don't think) and is doing quite well (NED I think?). Perhaps you can contact her with some questions… : )

      Here's hoping you find a new treatment soon!

      Michelle, wife of Don

       

        • August 26, 2011 at 1:03 am
        lhaley
        Participant

        Lynn is on the same trial but for those that are NED.She has a friend that is on that trial (at least I believe it's that one) who last I heard was doing well.  E-mail Lynn and I'm sure she will be able to help.

        • August 26, 2011 at 1:03 am
        lhaley
        Participant

        Lynn is on the same trial but for those that are NED.She has a friend that is on that trial (at least I believe it's that one) who last I heard was doing well.  E-mail Lynn and I'm sure she will be able to help.

      • August 24, 2011 at 8:41 pm
      Phil S
      Participant
      Boots. Look up the 8/11 post from MariaH, on HLA testing, it was discussed in that post. Determining HLA typing is done by simple blood test and most vaccine trials like the one you are talking about require HLA02 positive. I think some people are doing this trial at moffiit. Good luck to you. Valerie (Phil’s wife)
      • August 24, 2011 at 8:41 pm
      Phil S
      Participant
      Boots. Look up the 8/11 post from MariaH, on HLA testing, it was discussed in that post. Determining HLA typing is done by simple blood test and most vaccine trials like the one you are talking about require HLA02 positive. I think some people are doing this trial at moffiit. Good luck to you. Valerie (Phil’s wife)
      • August 25, 2011 at 1:45 am
      MariaH
      Participant

      Hi Boots!  Just wanted to let you know that an ESO trial as well as the MAGE trial were both presented to Dave at NIH once he found out he was not eligible for the TIL study.  We found out later he was HLA negative, but we did ask alot of questions regarding these while we were down in Bethesda.  I know that they are having very positive results with them.  I'm not sure if you would be doing this at NIH, and the procedure is different as NIH combined it with IL-2.  If I were you, I would definitely look into this seriously.  The science behind it makes sense, as technically you are blocking the cancer from growing and then teaching your immune system to recognize the tumors and attack.  Sounds like a "win, win" situation in my book.

      If you are HLA positive, it opens up a whole new scope on treatment options. 

      Best wishes,

      Maria

        • August 25, 2011 at 4:56 pm
        boot2aboot
        Participant

        thanks guys for helping me…i just found out i am A1 amd A11 (didn't know you could have more than one HLA type) 

        • August 25, 2011 at 4:56 pm
        boot2aboot
        Participant

        thanks guys for helping me…i just found out i am A1 amd A11 (didn't know you could have more than one HLA type) 

        • August 25, 2011 at 11:41 pm
        killmel
        Participant

        Hi,

        Where would you be doing this trial??? Who is the doctor sponsoring this trial for you? Have you been offered any other trial???

         

        Mary

        • August 25, 2011 at 11:41 pm
        killmel
        Participant

        Hi,

        Where would you be doing this trial??? Who is the doctor sponsoring this trial for you? Have you been offered any other trial???

         

        Mary

        • August 26, 2011 at 5:25 am
        JerryfromFauq
        Participant
        • August 26, 2011 at 5:25 am
        JerryfromFauq
        Participant
        • September 4, 2011 at 6:46 pm
        rbruce
        Participant

        Choel,

        Good to see your posting, but I couldn't figure out what treatment you are doing now.  My biochemo held things at bay, but didn't get rid of, or reduce, anything.  CPMC wants me to go on Yervoy and then I called my original Onc at UCSF and he suggested an anti-PD1 trial they have.  I had thought this was for Braf positive patients, which I am not.  Now it seems that a bloodtest will tell me if I'm HLA positive is what I need to do.  After reading about anti-PD1 I'd much rather go that route than IPI.  I had enough side effects with the biochemo (neuropathy, rashes, nausea) to last a lifetime and IPI seems to have it's share. 

        Let me know what you're up to?  Did you do biochemo?  How are you doing? and, are you thinking about the anti-PD1 trials? 

        Hope all is well.

        Robert

        • September 4, 2011 at 8:51 pm
        killmel
        Participant

        Is anyone participating in anti- PD-1 and what has been your experience. Thanks

        • September 4, 2011 at 8:51 pm
        killmel
        Participant

        Is anyone participating in anti- PD-1 and what has been your experience. Thanks

        • September 4, 2011 at 6:46 pm
        rbruce
        Participant

        Choel,

        Good to see your posting, but I couldn't figure out what treatment you are doing now.  My biochemo held things at bay, but didn't get rid of, or reduce, anything.  CPMC wants me to go on Yervoy and then I called my original Onc at UCSF and he suggested an anti-PD1 trial they have.  I had thought this was for Braf positive patients, which I am not.  Now it seems that a bloodtest will tell me if I'm HLA positive is what I need to do.  After reading about anti-PD1 I'd much rather go that route than IPI.  I had enough side effects with the biochemo (neuropathy, rashes, nausea) to last a lifetime and IPI seems to have it's share. 

        Let me know what you're up to?  Did you do biochemo?  How are you doing? and, are you thinking about the anti-PD1 trials? 

        Hope all is well.

        Robert

      • August 25, 2011 at 1:45 am
      MariaH
      Participant

      Hi Boots!  Just wanted to let you know that an ESO trial as well as the MAGE trial were both presented to Dave at NIH once he found out he was not eligible for the TIL study.  We found out later he was HLA negative, but we did ask alot of questions regarding these while we were down in Bethesda.  I know that they are having very positive results with them.  I'm not sure if you would be doing this at NIH, and the procedure is different as NIH combined it with IL-2.  If I were you, I would definitely look into this seriously.  The science behind it makes sense, as technically you are blocking the cancer from growing and then teaching your immune system to recognize the tumors and attack.  Sounds like a "win, win" situation in my book.

      If you are HLA positive, it opens up a whole new scope on treatment options. 

      Best wishes,

      Maria

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