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Any signs to know Braf/Mek drugs are working?

Forums General Melanoma Community Any signs to know Braf/Mek drugs are working?

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    Hi all,

    I posted awhile back about my mom’s diagnosis and treatment. She is now on braf/mek drugs and has been for 2.5 weeks. She seems to be tolerating them well so far, no noticeable side effects. Does this mean they aren’t working? She doesn’t have any tumours under the skin that we could “feel”, however we did notice what looks like a skin metastasis on her scalp. Would the braf/mek drugs somehow make this disappear even if its cutaneous? (that is if they are working). I almost feel more worried because she isn’t getting fevers, or rashes, nausea, etc.

    Would love to hear anybody else that has experience with this.

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      My anecdotal opinion is that the Braf/Mek drugs haven’t “felt like they’re working” in the way immunotherapy drugs have, with discomfort/inflammation at the sites of tumors. (That was my experience, anyway.) I was “lucky” to have several palpable tumors, and the targeted therapies did seem to be effective very quickly once I started them.

      I have gotten noticeable side effects from the Braf/Mek drugs I’ve taken within the first two weeks, but I don’t think that’s necessarily a gauge of effectiveness?

      Now that my palpable tumors are gone, I know how frustrating it is to not know what’s going on inside. :(



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