Any Merck anti PD-1 results?
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Any Merck anti PD-1 results?

› Forums › General Melanoma Community › Any Merck anti PD-1 results?

  • Post
    • March 9, 2012 at 5:04 am
    rbruce
    Participant

    just checking in to see if anyone has any results or comments to share from Merck's pd1 trial?  I start next week and would like to keep in touch with others n the trial.  Thanks, Robert

    just checking in to see if anyone has any results or comments to share from Merck's pd1 trial?  I start next week and would like to keep in touch with others n the trial.  Thanks, Robert

Viewing 5 reply threads
  • Replies
      • March 9, 2012 at 3:20 pm
      killmel
      Participant

      Hi Robert,

       

      That is great news that you are able to start the Merck trial. I am loking for a anti-pd1 trial.

      Where is the trial? How often do you get the infusions? Anthing else you can tell us about the trial would be greatly appreciated.

      Good Luck with the trial!

      Mike

        • March 9, 2012 at 9:02 pm
        rbruce
        Participant

        Mike, i will be at UCSF with Dr. Daud.   To start,  10 mg infusions will be every 2 weeks but there is rumor of an ammendment that will change it to every 3 weeks.  What therapies have you completed?  Are you braf+, or what mutation are you?  Robert

        • March 9, 2012 at 9:02 pm
        rbruce
        Participant

        Mike, i will be at UCSF with Dr. Daud.   To start,  10 mg infusions will be every 2 weeks but there is rumor of an ammendment that will change it to every 3 weeks.  What therapies have you completed?  Are you braf+, or what mutation are you?  Robert

        • March 9, 2012 at 9:02 pm
        rbruce
        Participant

        Mike, i will be at UCSF with Dr. Daud.   To start,  10 mg infusions will be every 2 weeks but there is rumor of an ammendment that will change it to every 3 weeks.  What therapies have you completed?  Are you braf+, or what mutation are you?  Robert

        • March 9, 2012 at 10:14 pm
        audgator
        Participant

        Mike, I start an anti-pd1 trial on Tuesday at Moffitt. It will be every other week for 12 weeks then another 12 weeks if I'm stable or improving.    Dan

        • March 10, 2012 at 6:57 am
        LynnLuc
        Participant

        Good Luck Dan! Its good you didn't need the right HLA in your Arm of the trial…I guess it's the peptides that required the specific HLA type! Perhaps I will see you down there…don't forget to check with the Social Worker about the other issue…Lynn

        • March 10, 2012 at 6:58 am
        LynnLuc
        Participant

        PS you may get a red flush the first few times you get it….

        • March 10, 2012 at 6:58 am
        LynnLuc
        Participant

        PS you may get a red flush the first few times you get it….

        • March 10, 2012 at 6:58 am
        LynnLuc
        Participant

        PS you may get a red flush the first few times you get it….

        • March 10, 2012 at 6:57 am
        LynnLuc
        Participant

        Good Luck Dan! Its good you didn't need the right HLA in your Arm of the trial…I guess it's the peptides that required the specific HLA type! Perhaps I will see you down there…don't forget to check with the Social Worker about the other issue…Lynn

        • March 10, 2012 at 6:57 am
        LynnLuc
        Participant

        Good Luck Dan! Its good you didn't need the right HLA in your Arm of the trial…I guess it's the peptides that required the specific HLA type! Perhaps I will see you down there…don't forget to check with the Social Worker about the other issue…Lynn

        • March 9, 2012 at 10:14 pm
        audgator
        Participant

        Mike, I start an anti-pd1 trial on Tuesday at Moffitt. It will be every other week for 12 weeks then another 12 weeks if I'm stable or improving.    Dan

        • March 9, 2012 at 10:14 pm
        audgator
        Participant

        Mike, I start an anti-pd1 trial on Tuesday at Moffitt. It will be every other week for 12 weeks then another 12 weeks if I'm stable or improving.    Dan

      • March 9, 2012 at 3:20 pm
      killmel
      Participant

      Hi Robert,

       

      That is great news that you are able to start the Merck trial. I am loking for a anti-pd1 trial.

      Where is the trial? How often do you get the infusions? Anthing else you can tell us about the trial would be greatly appreciated.

      Good Luck with the trial!

      Mike

      • March 9, 2012 at 3:20 pm
      killmel
      Participant

      Hi Robert,

       

      That is great news that you are able to start the Merck trial. I am loking for a anti-pd1 trial.

      Where is the trial? How often do you get the infusions? Anthing else you can tell us about the trial would be greatly appreciated.

      Good Luck with the trial!

      Mike

      • March 10, 2012 at 3:07 am
      melmar
      Participant
      Robert – Glad to hear you are starting on anti pd-1. I have not posted on this forum before. As a recently diagnosed stage 4 melanoma patient I have spent countless hours on this site learning as much as possible but haven’t had much to contribute until now. (thank you by the way to all of the knowledgeable posters helping us newbies find our way). Anyway, I started on merck 3475 trial at the Angeles clinic in January after researching a number of trials and doctors. Like you, i go every two weeks for infusions. (The clinic is amazing by the way) I just finished my fourth treatment and have had virtually no side effects worth mentioning. It is early in the trial, but I am told they are seeing good results. I am so hopeful and will stay in touch as I learn more.
        • March 10, 2012 at 8:05 am
        rbruce
        Participant

        Thanks for your post, its great to hear about minimal side effects.  Do they do a pre infusion medication of any kind? Is Hamid your doctor? i'll check out your profile.  I'd love to stay in touch as there are not many in the trial and it will be good to share exoeriences.  God bless and take care.  Robert

        • March 10, 2012 at 10:34 am
        melmar
        Participant
        Robert,
        There are no pre-infusion medications — Just labs followed by 1/2 hour infusion every other week. Dr. Hamid is my doctor. I haven’t yet created a profile but will do so after this post. Thanks again to you and others for sharing their experiences. I am so thankful to have found this site and will happily stay in touch regarding this trial. My thoughts and prayers go to you and others on this site fighting the battle.
        Margo
        • March 12, 2012 at 8:10 pm
        boot2aboot
        Participant

        Robert,

        my onc said that the Bristol Myers (older anti PD1) made some of her stage 4 patients NED…i can't get on it until Zelboraf quits working…

        boots

        • March 13, 2012 at 12:16 am
        rbruce
        Participant
        Thanks Boots for the encouraging words. I’m in SF for labs today, biopsy tomorrow and infusion on Thursday. I’ll.let u know how it goes. Robert
        • March 16, 2012 at 12:35 am
        killmel
        Participant

        Hi Robert,

        How oftern do you get infusions for this drug?? What are the side effects??

        Wishing you good luck with this trial.

        Mary

        • March 16, 2012 at 12:35 am
        killmel
        Participant

        Hi Robert,

        How oftern do you get infusions for this drug?? What are the side effects??

        Wishing you good luck with this trial.

        Mary

        • March 16, 2012 at 12:35 am
        killmel
        Participant

        Hi Robert,

        How oftern do you get infusions for this drug?? What are the side effects??

        Wishing you good luck with this trial.

        Mary

        • March 13, 2012 at 12:16 am
        rbruce
        Participant
        Thanks Boots for the encouraging words. I’m in SF for labs today, biopsy tomorrow and infusion on Thursday. I’ll.let u know how it goes. Robert
        • March 13, 2012 at 12:16 am
        rbruce
        Participant
        Thanks Boots for the encouraging words. I’m in SF for labs today, biopsy tomorrow and infusion on Thursday. I’ll.let u know how it goes. Robert
        • March 12, 2012 at 8:10 pm
        boot2aboot
        Participant

        Robert,

        my onc said that the Bristol Myers (older anti PD1) made some of her stage 4 patients NED…i can't get on it until Zelboraf quits working…

        boots

        • March 12, 2012 at 8:10 pm
        boot2aboot
        Participant

        Robert,

        my onc said that the Bristol Myers (older anti PD1) made some of her stage 4 patients NED…i can't get on it until Zelboraf quits working…

        boots

        • March 10, 2012 at 10:34 am
        melmar
        Participant
        Robert,
        There are no pre-infusion medications — Just labs followed by 1/2 hour infusion every other week. Dr. Hamid is my doctor. I haven’t yet created a profile but will do so after this post. Thanks again to you and others for sharing their experiences. I am so thankful to have found this site and will happily stay in touch regarding this trial. My thoughts and prayers go to you and others on this site fighting the battle.
        Margo
        • March 10, 2012 at 10:34 am
        melmar
        Participant
        Robert,
        There are no pre-infusion medications — Just labs followed by 1/2 hour infusion every other week. Dr. Hamid is my doctor. I haven’t yet created a profile but will do so after this post. Thanks again to you and others for sharing their experiences. I am so thankful to have found this site and will happily stay in touch regarding this trial. My thoughts and prayers go to you and others on this site fighting the battle.
        Margo
        • March 10, 2012 at 8:05 am
        rbruce
        Participant

        Thanks for your post, its great to hear about minimal side effects.  Do they do a pre infusion medication of any kind? Is Hamid your doctor? i'll check out your profile.  I'd love to stay in touch as there are not many in the trial and it will be good to share exoeriences.  God bless and take care.  Robert

        • March 10, 2012 at 8:05 am
        rbruce
        Participant

        Thanks for your post, its great to hear about minimal side effects.  Do they do a pre infusion medication of any kind? Is Hamid your doctor? i'll check out your profile.  I'd love to stay in touch as there are not many in the trial and it will be good to share exoeriences.  God bless and take care.  Robert

        • March 16, 2012 at 12:39 am
        killmel
        Participant

        Hi,

         

        I read your profile that state you live in Alaska.

        How do you get infusions every 2 weeks…do you commute from Alaska?

        Good Luckwith your trial.

        Dave

        • March 16, 2012 at 12:39 am
        killmel
        Participant

        Hi,

         

        I read your profile that state you live in Alaska.

        How do you get infusions every 2 weeks…do you commute from Alaska?

        Good Luckwith your trial.

        Dave

        • March 16, 2012 at 12:39 am
        killmel
        Participant

        Hi,

         

        I read your profile that state you live in Alaska.

        How do you get infusions every 2 weeks…do you commute from Alaska?

        Good Luckwith your trial.

        Dave

        • March 16, 2012 at 12:42 am
        killmel
        Participant

        Hi Margo

         

         

        I read your profile that state you live in Alaska.

        How do you get infusions every 2 weeks…do you commute from Alaska?

        Good Luckwith your trial.

        Dave

        • March 16, 2012 at 12:42 am
        killmel
        Participant

        Hi Margo

         

         

        I read your profile that state you live in Alaska.

        How do you get infusions every 2 weeks…do you commute from Alaska?

        Good Luckwith your trial.

        Dave

        • March 19, 2012 at 4:55 am
        melmar
        Participant

        Yes.  I travel from Alaska every two weeks.  It is a bit of logistical nightmare — not to mention expense, but I also really like the clinic / Dr. Hamid and am very optimistic about the trial.  I guess my motto should be "will travel for cure".        

        • March 19, 2012 at 4:55 am
        melmar
        Participant

        Yes.  I travel from Alaska every two weeks.  It is a bit of logistical nightmare — not to mention expense, but I also really like the clinic / Dr. Hamid and am very optimistic about the trial.  I guess my motto should be "will travel for cure".        

        • March 19, 2012 at 4:55 am
        melmar
        Participant

        Yes.  I travel from Alaska every two weeks.  It is a bit of logistical nightmare — not to mention expense, but I also really like the clinic / Dr. Hamid and am very optimistic about the trial.  I guess my motto should be "will travel for cure".        

        • March 16, 2012 at 12:42 am
        killmel
        Participant

        Hi Margo

         

         

        I read your profile that state you live in Alaska.

        How do you get infusions every 2 weeks…do you commute from Alaska?

        Good Luckwith your trial.

        Dave

      • March 10, 2012 at 3:07 am
      melmar
      Participant
      Robert – Glad to hear you are starting on anti pd-1. I have not posted on this forum before. As a recently diagnosed stage 4 melanoma patient I have spent countless hours on this site learning as much as possible but haven’t had much to contribute until now. (thank you by the way to all of the knowledgeable posters helping us newbies find our way). Anyway, I started on merck 3475 trial at the Angeles clinic in January after researching a number of trials and doctors. Like you, i go every two weeks for infusions. (The clinic is amazing by the way) I just finished my fourth treatment and have had virtually no side effects worth mentioning. It is early in the trial, but I am told they are seeing good results. I am so hopeful and will stay in touch as I learn more.
      • March 10, 2012 at 3:07 am
      melmar
      Participant
      Robert – Glad to hear you are starting on anti pd-1. I have not posted on this forum before. As a recently diagnosed stage 4 melanoma patient I have spent countless hours on this site learning as much as possible but haven’t had much to contribute until now. (thank you by the way to all of the knowledgeable posters helping us newbies find our way). Anyway, I started on merck 3475 trial at the Angeles clinic in January after researching a number of trials and doctors. Like you, i go every two weeks for infusions. (The clinic is amazing by the way) I just finished my fourth treatment and have had virtually no side effects worth mentioning. It is early in the trial, but I am told they are seeing good results. I am so hopeful and will stay in touch as I learn more.
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