Any data regarding Immunotherapy effectiveness after BRAF vs before BRAF in mutant patients?

This topic has 10 replies, 3 voices, and was last updated 9 years, 1 month ago by Bubbles.

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- February 15, 2017 at 11:51 pm
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Spl25
Participant

I know there are a few clinical trials looking into this, but I'm looking for data (even preclinical) regarding whether Melanoma cells are *more* or *less* likely to be recognized by cytotoxic immune cells after BRAF therapy. Has anybody heard of a CR or durable response to PD-1 *after* BRAF inhibition? I've certainly heard the stories of disease coming back "angry" after BRAF therapy (in the minority of patients, of course).

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- - February 16, 2017 at 12:13 am
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  ed williams
  Participant
  
  Best I have is from ESMO 2016 panel with Dr. Weber, https://www.youtube.com/watch?v=0tL6uLzj6hc 
- - February 16, 2017 at 12:13 am
  - Quote
  ed williams
  Participant
  
  Best I have is from ESMO 2016 panel with Dr. Weber, https://www.youtube.com/watch?v=0tL6uLzj6hc 
- - February 16, 2017 at 12:13 am
  - Quote
  ed williams
  Participant
  
  Best I have is from ESMO 2016 panel with Dr. Weber, https://www.youtube.com/watch?v=0tL6uLzj6hc 
  - February 16, 2017 at 3:34 am
    
    Quote
    Spl25
    Participant
    
    Thank you so much Ed!
  - February 16, 2017 at 3:34 am
    
    Quote
    Spl25
    Participant
    
    Thank you so much Ed!
- - February 16, 2017 at 12:16 am
  - Quote
  ed williams
  Participant
  
  Plus this from same series at ESMO 2016, https://www.youtube.com/watch?v=NE2KL43UtiA
- - February 16, 2017 at 12:16 am
  - Quote
  ed williams
  Participant
  
  Plus this from same series at ESMO 2016, https://www.youtube.com/watch?v=NE2KL43UtiA
- - February 16, 2017 at 12:16 am
  - Quote
  ed williams
  Participant
  
  Plus this from same series at ESMO 2016, https://www.youtube.com/watch?v=NE2KL43UtiA
- - February 16, 2017 at 2:45 pm
  - Quote
  Bubbles
  Participant
  
  Melanoma experts often discuss the benefit of using BRAF/MEK to decrease tumor burden rapidly in BRAF positive patients with the plan to then swtich to immunotherapy as soon as a decreased burden is attained.
  
  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/09/pick-your-poison-weber-and-agarwala.html
  
  More and more new studies are looking at combining BRAF/MEK with immunotherapy – so we will have to see how that works out….but here is some data out of ASCO last year that demonstrates…YES! Patients who have been treated with BRAFi can respond to "just" anti-PD1 (and this was with brain mets!!!):
  
  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/06/asco-2016-anti-pd1pdl1-combined-with.html
  
  I wish you well. Celeste
- - February 16, 2017 at 2:45 pm
  - Quote
  Bubbles
  Participant
  
  Melanoma experts often discuss the benefit of using BRAF/MEK to decrease tumor burden rapidly in BRAF positive patients with the plan to then swtich to immunotherapy as soon as a decreased burden is attained.
  
  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/09/pick-your-poison-weber-and-agarwala.html
  
  More and more new studies are looking at combining BRAF/MEK with immunotherapy – so we will have to see how that works out….but here is some data out of ASCO last year that demonstrates…YES! Patients who have been treated with BRAFi can respond to "just" anti-PD1 (and this was with brain mets!!!):
  
  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/06/asco-2016-anti-pd1pdl1-combined-with.html
  
  I wish you well. Celeste

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Any data regarding Immunotherapy effectiveness after BRAF vs before BRAF in mutant patients?

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