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AntiPD1 after BRaf inhibitor
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AntiPD1 after BRaf inhibitor

› Forums › General Melanoma Community › AntiPD1 after BRaf inhibitor

  • Post
    • July 24, 2014 at 4:53 am
    Nadia
    Participant

      Is there a washout period for Dabrafenib required before the start of antiPD1?  My hubs was supposed to start antiPD1, so he was taken offf Dabrafenib for a month long washout and almost immediately he started to feel sick, nauseous, tired.  Also, in 4 days, he started to feel some of his tumours starting to grow.  Dr. phoned a week later ( my husband was feeling progressively worse) and said it will be another month until hubs gets antiPD1, and when he heard my husband feels this's sick he recommended to go back on Dabrafenib until pd1 is available.  In two days his vomiting stopped, and  his tumours started shrinking again.  

      It was shocking -to say the least- how fast everything changed.  I know it's a matter of time until he will get antiPD1. But now I'm really worried that his condition will deteriorate very rapid when he'll go off Dabrafenib in the washout so I'm wondering why a washout period and not take it  until the day before the first pd1 infusion.  Also, let's say, he's taking it without dr's knowledge, will this show up in blood tests?

      we were aware how quick things may change when interrupting Dabrafenib, but to get this sick in a matter of days was shocking and eye opening.  And very scarry.

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    • Replies
        • July 24, 2014 at 7:25 pm
        jualonso
        Participant

          Hi,

          I would like to belp you but an important question is not mentioned. Why do you decide to stop dabrafenib? Is not working anymore and you are progressing?

           

          • July 24, 2014 at 7:25 pm
          jualonso
          Participant

            Hi,

            I would like to belp you but an important question is not mentioned. Why do you decide to stop dabrafenib? Is not working anymore and you are progressing?

             

            • July 24, 2014 at 7:25 pm
            jualonso
            Participant

              Hi,

              I would like to belp you but an important question is not mentioned. Why do you decide to stop dabrafenib? Is not working anymore and you are progressing?

               

          Viewing 2 reply threads
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