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Antihistamines can influence immunotherapy response?

Forums General Melanoma Community Antihistamines can influence immunotherapy response?

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      ed williams
      Participant
        Interesting idea, there is a lot of research going on with macrophages at present and the Vista checkpoint reminds me of a few years back when LAG-3 checkpoint research was in it’s early days. LAG-3 is now close to FDA approval with Relatlimab. CTLA-4, PD-1, LAG-3 now Vista, those checkpoint look to be worth the time and investment and payoff in the end. It will be interesting to see how they set up a prospective trial and who will sponsor it? $$$ always come into play at some point. Thanks for sharing!!! Ed
        Bubbles
        Participant
          I saw this report, too.  Pretty cool intel.  However, don’t know about the rest of you peeps – but as I have mentioned in regard to the reports (kinda old now) about the possible increased benefit NSAID can offer when combined with immunotherapy – between the rashes and arthralgias – I lived on benadryl and advil during my nivo treatments.  I would suspect it would be hard to find a group of immunotherapy peeps for whom that is not true!!!

          Just my thoughts.  Best to all.  c

          Christinad
          Participant
            Very true, Celeste. This would br difficult to study since NSAIDS and antihistamines are sold OTC. There’s no way to ensure one group does or does not take these meds. As Ed mentioned it would be interesting to study and I’d also be curious to see how the trial would be set up (if it ever happens). 🤔
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