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Anti PD-1 test
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Anti PD-1 test

› Forums › General Melanoma Community › Anti PD-1 test

  • Post
    • July 31, 2017 at 2:12 pm
    adrianc
    Participant

      I have noticed  that on the Keytruda commercial currently being shown on the CBS, the patient mentioned that she had been tested for anti PD-1 and was found positive, therefore she was Keytruda responder.

      I am curious if any of you melanoma warriors have been tested for anti-PD1 prior to starting immunotherapy /both Ipi/Nivo or Nivo and Pembro alone/ ?

      Logically does the absence of the anti-PD1 marker imply that a patient would be non-responder to the immunotherapy?

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    • Replies
        • July 31, 2017 at 4:13 pm
        Julie in SoCal
        Participant

          Hi Anon,

          I was tested as a part of my non-small cell lung cancer protocol.  Turns out I only have a 5% expression in my lung tumor.  While I was on Pembro, though, I watched my in-transit tumors melt away.  So I don't know what the deal is.  

          Shalom,

          Julie

            • July 31, 2017 at 5:25 pm
            adrianc
            Participant

              Txs for taking the time,Julie

            • July 31, 2017 at 4:17 pm
            ed williams
            Participant

              Hi Anon, the short answer is no, Pd-L1 + doesn't mean that you will repond vs if you are pd-L1- but Pd-L1+ do better as a % of total patients in trials. I have two links for you if you are interested, the first one covers melanoma and Non small cell lung cancer, while the second link is specific to decision making in  Melanoma based on Pd-L1 status. Best Wishes!!! Ed https://www.youtube.com/watch?v=5y1nnTsFBoE  https://www.youtube.com/watch?v=HvB8cZj_qeI

                • July 31, 2017 at 5:25 pm
                adrianc
                Participant

                  Thank you for your reply,Ed.

                  • August 1, 2017 at 5:10 am
                  UBContributor
                  Participant

                    thank u for explanation, much better than in those large articles, lol

                     

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