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After 48 weeks on BRAF/MEK trial, the drugs no longer work. Plan B???

Forums General Melanoma Community After 48 weeks on BRAF/MEK trial, the drugs no longer work. Plan B???

  • Post
    mommydog
    Participant

    The oncologist told us today that my husband's latest PET/CT disclosed a couple of new mets and some growth in pre-exisiting mets.  This means that the drugs are no longer working for him and we are on to plan B, which we need to decide upon very soon.  The two options the doctor presented were:

     

    1. enrollment in a phase two clinical trial by MERCK on PD-1 or:

    2. treatment with Yervoy and the Roche BRAF inhibitor as a combination therapy.

     

    The doctor said if it were him, he would do the trial.

     

    The oncologist told us today that my husband's latest PET/CT disclosed a couple of new mets and some growth in pre-exisiting mets.  This means that the drugs are no longer working for him and we are on to plan B, which we need to decide upon very soon.  The two options the doctor presented were:

     

    1. enrollment in a phase two clinical trial by MERCK on PD-1 or:

    2. treatment with Yervoy and the Roche BRAF inhibitor as a combination therapy.

     

    The doctor said if it were him, he would do the trial.

     

    Does anyone have any informtion on the PD-1 trials?

     

    Thanks

    Deborah

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  • Replies
      deardad
      Participant

      Im sorry to hear the inhibitors have stopped working. My dad is currently on his 5th cycle of vermurafenib and we are in that buying time period. I'm not sure what to go with next but PD-1 sounds encouraging. I can't remember her name but she was seeing Dr Weber at MD Anderson and mentioned that MDX1106 aka BMS926556 is one of the better PD-1 drugs. I'm thinking your doctor is probably correct in recommending the trial as you may always try the 2nd option as plan C.

      Take care and don't ever look back at the decision you make.

      Nahmi

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      deardad
      Participant

      Im sorry to hear the inhibitors have stopped working. My dad is currently on his 5th cycle of vermurafenib and we are in that buying time period. I'm not sure what to go with next but PD-1 sounds encouraging. I can't remember her name but she was seeing Dr Weber at MD Anderson and mentioned that MDX1106 aka BMS926556 is one of the better PD-1 drugs. I'm thinking your doctor is probably correct in recommending the trial as you may always try the 2nd option as plan C.

      Take care and don't ever look back at the decision you make.

      Nahmi

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      deardad
      Participant

      Im sorry to hear the inhibitors have stopped working. My dad is currently on his 5th cycle of vermurafenib and we are in that buying time period. I'm not sure what to go with next but PD-1 sounds encouraging. I can't remember her name but she was seeing Dr Weber at MD Anderson and mentioned that MDX1106 aka BMS926556 is one of the better PD-1 drugs. I'm thinking your doctor is probably correct in recommending the trial as you may always try the 2nd option as plan C.

      Take care and don't ever look back at the decision you make.

      Nahmi

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      LynnLuc
      Participant

      I am in the MDX 1106 ( anti PD-1 ) trial at Moffitt with Dr Weber. I am doing great and March 26 I will have my 2 years of NED . I am stage 4!

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      LynnLuc
      Participant

      I am in the MDX 1106 ( anti PD-1 ) trial at Moffitt with Dr Weber. I am doing great and March 26 I will have my 2 years of NED . I am stage 4!

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      LynnLuc
      Participant

      I am in the MDX 1106 ( anti PD-1 ) trial at Moffitt with Dr Weber. I am doing great and March 26 I will have my 2 years of NED . I am stage 4!

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      MeNDave
      Participant

      Hi Deborah,

      I have heard that the anti-pd1 trials are showing better results than Yervoy (up to 33% response), but that is through the grapevine.  However, I do know that some of the anti-pd1 trials will not allow prior treatment with Yervoy, so you may want to keep that in mind. 

      Best wishes in whatever you decide,

      Maria

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        LynnLuc
        Participant

        I think originally they did not allow prior use of Yervoy, like in my trial ( mine was for surgically resected)…but the sister trial , which if those not NED has an arm with previous Yervoy use…now they are even combining the two ( or so I heard!)

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        LynnLuc
        Participant

        I think originally they did not allow prior use of Yervoy, like in my trial ( mine was for surgically resected)…but the sister trial , which if those not NED has an arm with previous Yervoy use…now they are even combining the two ( or so I heard!)

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        boot2aboot
        Participant

         

        You have to be HLA_A2 to be on moffitts anti-pd1tial…that leaves a lot of us out in the cold…anti PD-1, depending on the version, is about 35 % effective…that means PR and CRs…i think Yervoy is something like 15%…then there is IL2…5% and Adoptive  Cell Transfer which is rough and tough that includes IL2…numbers are good though something around 30-40% PRs…i would look at Adoptive Cell Transfer and older versions of anti PD1/PDLs…if anti PD1 works, it will do so very fast…or not at all….

        boots

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        boot2aboot
        Participant

         

        You have to be HLA_A2 to be on moffitts anti-pd1tial…that leaves a lot of us out in the cold…anti PD-1, depending on the version, is about 35 % effective…that means PR and CRs…i think Yervoy is something like 15%…then there is IL2…5% and Adoptive  Cell Transfer which is rough and tough that includes IL2…numbers are good though something around 30-40% PRs…i would look at Adoptive Cell Transfer and older versions of anti PD1/PDLs…if anti PD1 works, it will do so very fast…or not at all….

        boots

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        boot2aboot
        Participant

         

        You have to be HLA_A2 to be on moffitts anti-pd1tial…that leaves a lot of us out in the cold…anti PD-1, depending on the version, is about 35 % effective…that means PR and CRs…i think Yervoy is something like 15%…then there is IL2…5% and Adoptive  Cell Transfer which is rough and tough that includes IL2…numbers are good though something around 30-40% PRs…i would look at Adoptive Cell Transfer and older versions of anti PD1/PDLs…if anti PD1 works, it will do so very fast…or not at all….

        boots

        Loading spinner
        boot2aboot
        Participant

         

        You have to be HLA_A2 to be on moffitts anti-pd1tial…that leaves a lot of us out in the cold…anti PD-1, depending on the version, is about 35 % effective…that means PR and CRs…i think Yervoy is something like 15%…then there is IL2…5% and Adoptive  Cell Transfer which is rough and tough that includes IL2…numbers are good though something around 30-40% PRs…i would look at Adoptive Cell Transfer and older versions of anti PD1/PDLs…if anti PD1 works, it will do so very fast…or not at all….

        boots

        Loading spinner
        boot2aboot
        Participant

         

        You have to be HLA_A2 to be on moffitts anti-pd1tial…that leaves a lot of us out in the cold…anti PD-1, depending on the version, is about 35 % effective…that means PR and CRs…i think Yervoy is something like 15%…then there is IL2…5% and Adoptive  Cell Transfer which is rough and tough that includes IL2…numbers are good though something around 30-40% PRs…i would look at Adoptive Cell Transfer and older versions of anti PD1/PDLs…if anti PD1 works, it will do so very fast…or not at all….

        boots

        Loading spinner
        boot2aboot
        Participant

         

        You have to be HLA_A2 to be on moffitts anti-pd1tial…that leaves a lot of us out in the cold…anti PD-1, depending on the version, is about 35 % effective…that means PR and CRs…i think Yervoy is something like 15%…then there is IL2…5% and Adoptive  Cell Transfer which is rough and tough that includes IL2…numbers are good though something around 30-40% PRs…i would look at Adoptive Cell Transfer and older versions of anti PD1/PDLs…if anti PD1 works, it will do so very fast…or not at all….

        boots

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        LynnLuc
        Participant

        I think originally they did not allow prior use of Yervoy, like in my trial ( mine was for surgically resected)…but the sister trial , which if those not NED has an arm with previous Yervoy use…now they are even combining the two ( or so I heard!)

        Loading spinner
      MeNDave
      Participant

      Hi Deborah,

      I have heard that the anti-pd1 trials are showing better results than Yervoy (up to 33% response), but that is through the grapevine.  However, I do know that some of the anti-pd1 trials will not allow prior treatment with Yervoy, so you may want to keep that in mind. 

      Best wishes in whatever you decide,

      Maria

      Loading spinner
      MeNDave
      Participant

      Hi Deborah,

      I have heard that the anti-pd1 trials are showing better results than Yervoy (up to 33% response), but that is through the grapevine.  However, I do know that some of the anti-pd1 trials will not allow prior treatment with Yervoy, so you may want to keep that in mind. 

      Best wishes in whatever you decide,

      Maria

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      Rdev01
      Participant
      I am stage IV and just got out of Merck’s PD-1 MK 3475 trial Phase 1. It seemed to work well first month(some 15% reductions)but stopped for me based on 2nd month scans. I’m now on Zelboraf at 8th day and already am noticing significant reduction in palpable scalp/neck nodules.

      Loading spinner
      Rdev01
      Participant
      I am stage IV and just got out of Merck’s PD-1 MK 3475 trial Phase 1. It seemed to work well first month(some 15% reductions)but stopped for me based on 2nd month scans. I’m now on Zelboraf at 8th day and already am noticing significant reduction in palpable scalp/neck nodules.

      Loading spinner
      Rdev01
      Participant
      I am stage IV and just got out of Merck’s PD-1 MK 3475 trial Phase 1. It seemed to work well first month(some 15% reductions)but stopped for me based on 2nd month scans. I’m now on Zelboraf at 8th day and already am noticing significant reduction in palpable scalp/neck nodules.

      Loading spinner
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