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adjuvant therapy?
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adjuvant therapy?

› Forums › General Melanoma Community › adjuvant therapy?

  • Post
    • October 28, 2014 at 3:25 pm
    Adrian G
    Participant

       

       

      Hi,

       

      my sister has been diagnosedwith malignant melanoma in 2009 stage 3. She had 3 surgeries to removed the primary and lymph nodes. After that was receiving chimo, interferon and radiotherapy.

      This august on the last CT scan a lymph node (between the kidney and spleen) was looking suspicious on the image. 

      She had a surgery to completely remove the lymph node (fully encapsulted and tested positive for melanoma). Everything else looks clean. 

      Does she need any adjuvant therapy after sugery? 

       

      Many thanks

      Adrian

    Viewing 5 reply threads
    • Replies
        • October 28, 2014 at 3:32 pm
        Janner
        Participant

          If she has already done Interferon, then there really is no other adjuvant therapy available unless she looks into clinical trials.  Right now, only Interferon is approved for stage III.  Is the new lymph node "distant" making her stage IV?  She might have a few more clinical trial options that way, but there just aren't many treatments available for stage III/IV with NED (no evidence of disease).  I'd check out clinicaltrials.gov to see what options might be available.

          • October 28, 2014 at 3:32 pm
          Janner
          Participant

            If she has already done Interferon, then there really is no other adjuvant therapy available unless she looks into clinical trials.  Right now, only Interferon is approved for stage III.  Is the new lymph node "distant" making her stage IV?  She might have a few more clinical trial options that way, but there just aren't many treatments available for stage III/IV with NED (no evidence of disease).  I'd check out clinicaltrials.gov to see what options might be available.

            • October 28, 2014 at 3:32 pm
            Janner
            Participant

              If she has already done Interferon, then there really is no other adjuvant therapy available unless she looks into clinical trials.  Right now, only Interferon is approved for stage III.  Is the new lymph node "distant" making her stage IV?  She might have a few more clinical trial options that way, but there just aren't many treatments available for stage III/IV with NED (no evidence of disease).  I'd check out clinicaltrials.gov to see what options might be available.

              • October 28, 2014 at 5:15 pm
              arthurjedi007
              Participant

                Celeste just posted this a little while ago on another post about a stage 3 NED trial. Figured I should post her post here too so you see it. So here is her post from that post but it seems like it should apply to you as well I think:

                 

                I don't know anything about the test you are using.  However, if you are stage III and are interested in taking action…there is an NED trial for folks Stage III and IV combining ipi and nivo available at Moffitt in Tampa, Florida. 

                Here's a description of it from my blog:  "A new cohort #5 has been created.  It will accept 1,500 resected melanoma patients, from Stage III B/C to Stage IV.  Due to the high incidence of side effects with the prior combo….the dosages were flipped.  These patients will now be given Nivo at 3mg/kg and Ipi at 1 mg/kg.  Side effects remain a concern, especially for those at Stage IIIB as their risk for their melanoma is less than that of NED patients Staged IIIC/IV, and such side effects always have to be weighed against risk of disease, but should be decreased for everyone with this particular dosing plan.  There is no HLA typing requirement as no vaccines will be given."

                Here is a link to it on the clinicaltrials.gov site (scroll on down once at this trial!):  http://clinicaltrials.gov/ct2/show/NCT01176474?term=melanoma+adjuvant&rank=160

                You can also go to the first page of clinicaltrials.gov and put in Stage III and melanoma and see what other options might be out there if you are interested.

                I wish you my best, Celeste

                chaoticallypreciselifeloveandmelanoma.blogspot.com

                 

                Artie

                  • November 1, 2014 at 3:53 pm
                  oldblue
                  Participant

                    Yes. There is adjuant therapy for stage 3b and 3c via a clinical trial now. It has just started, I believe.

                    I don't have the details to hand but it seems to have replaced the combi ad trial with the same drugs and not randomised between placebo and the drugs.

                    I was offered it. they advised take the drugs for three months, have surgery on a suspect lymph node and then continue on the drugs for another nine months. 

                    Further tests showed the lymph node not to be suspect so I am one of the last to go on combi ad. I am sitting here after two doses sweating and hot so unless I am kidding myself I am getting the real thing.

                    If you can't find the information on the trial then pleasemessage me and I will find it for you.

                    • November 1, 2014 at 3:53 pm
                    oldblue
                    Participant

                      Yes. There is adjuant therapy for stage 3b and 3c via a clinical trial now. It has just started, I believe.

                      I don't have the details to hand but it seems to have replaced the combi ad trial with the same drugs and not randomised between placebo and the drugs.

                      I was offered it. they advised take the drugs for three months, have surgery on a suspect lymph node and then continue on the drugs for another nine months. 

                      Further tests showed the lymph node not to be suspect so I am one of the last to go on combi ad. I am sitting here after two doses sweating and hot so unless I am kidding myself I am getting the real thing.

                      If you can't find the information on the trial then pleasemessage me and I will find it for you.

                      • November 1, 2014 at 3:53 pm
                      oldblue
                      Participant

                        Yes. There is adjuant therapy for stage 3b and 3c via a clinical trial now. It has just started, I believe.

                        I don't have the details to hand but it seems to have replaced the combi ad trial with the same drugs and not randomised between placebo and the drugs.

                        I was offered it. they advised take the drugs for three months, have surgery on a suspect lymph node and then continue on the drugs for another nine months. 

                        Further tests showed the lymph node not to be suspect so I am one of the last to go on combi ad. I am sitting here after two doses sweating and hot so unless I am kidding myself I am getting the real thing.

                        If you can't find the information on the trial then pleasemessage me and I will find it for you.

                      • October 28, 2014 at 5:15 pm
                      arthurjedi007
                      Participant

                        Celeste just posted this a little while ago on another post about a stage 3 NED trial. Figured I should post her post here too so you see it. So here is her post from that post but it seems like it should apply to you as well I think:

                         

                        I don't know anything about the test you are using.  However, if you are stage III and are interested in taking action…there is an NED trial for folks Stage III and IV combining ipi and nivo available at Moffitt in Tampa, Florida. 

                        Here's a description of it from my blog:  "A new cohort #5 has been created.  It will accept 1,500 resected melanoma patients, from Stage III B/C to Stage IV.  Due to the high incidence of side effects with the prior combo….the dosages were flipped.  These patients will now be given Nivo at 3mg/kg and Ipi at 1 mg/kg.  Side effects remain a concern, especially for those at Stage IIIB as their risk for their melanoma is less than that of NED patients Staged IIIC/IV, and such side effects always have to be weighed against risk of disease, but should be decreased for everyone with this particular dosing plan.  There is no HLA typing requirement as no vaccines will be given."

                        Here is a link to it on the clinicaltrials.gov site (scroll on down once at this trial!):  http://clinicaltrials.gov/ct2/show/NCT01176474?term=melanoma+adjuvant&rank=160

                        You can also go to the first page of clinicaltrials.gov and put in Stage III and melanoma and see what other options might be out there if you are interested.

                        I wish you my best, Celeste

                        chaoticallypreciselifeloveandmelanoma.blogspot.com

                         

                        Artie

                        • October 28, 2014 at 5:15 pm
                        arthurjedi007
                        Participant

                          Celeste just posted this a little while ago on another post about a stage 3 NED trial. Figured I should post her post here too so you see it. So here is her post from that post but it seems like it should apply to you as well I think:

                           

                          I don't know anything about the test you are using.  However, if you are stage III and are interested in taking action…there is an NED trial for folks Stage III and IV combining ipi and nivo available at Moffitt in Tampa, Florida. 

                          Here's a description of it from my blog:  "A new cohort #5 has been created.  It will accept 1,500 resected melanoma patients, from Stage III B/C to Stage IV.  Due to the high incidence of side effects with the prior combo….the dosages were flipped.  These patients will now be given Nivo at 3mg/kg and Ipi at 1 mg/kg.  Side effects remain a concern, especially for those at Stage IIIB as their risk for their melanoma is less than that of NED patients Staged IIIC/IV, and such side effects always have to be weighed against risk of disease, but should be decreased for everyone with this particular dosing plan.  There is no HLA typing requirement as no vaccines will be given."

                          Here is a link to it on the clinicaltrials.gov site (scroll on down once at this trial!):  http://clinicaltrials.gov/ct2/show/NCT01176474?term=melanoma+adjuvant&rank=160

                          You can also go to the first page of clinicaltrials.gov and put in Stage III and melanoma and see what other options might be out there if you are interested.

                          I wish you my best, Celeste

                          chaoticallypreciselifeloveandmelanoma.blogspot.com

                           

                          Artie

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