› Forums › General Melanoma Community › ACTION! Help Save the Life of Darcy Doherty, Father of Three Children to get immunotherapy drug Anti-PD-1 (BMS-936558) for mela
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- June 18, 2012 at 2:51 pm
ACTION! Help Save the Life of Darcy Doherty, Father of Three Children to get immunotherapy drug Anti-PD-1 (BMS-936558) for melanoma .
ACTION! Help Save the Life of Darcy Doherty, Father of Three Children to get immunotherapy drug Anti-PD-1 (BMS-936558) for melanoma .
Please write to Dr. Elliot Sigal at Bristol Myer Squib
Dr. Sigal is the Director of Research at BMS.
Please send a note to Dr. Sigal requesting that BMS open compassionate use for Mr. Doherty. I know it is a long shot/ Hail Mary Pass but, base on my research, this drug with the combination of IL-2 may be able to beat the odds.
Bristol Myer Squib says "At Bristol-Myers Squibb, we are firmly focused on our Mission to discover, develop and deliver innovative medicines that help patients prevail over serious diseases."
Is this all lip service? Let see if BMS puts their money where their mouth is and grant this compassionate care use for this derserving family. Doherty with his clinal trial of Yervoy (Anti-CTLA-4 therapy) helped get the drug FDA approved through his survival data. The least Bristol could do is to grant the dying man compassionate use of the next generation drug called Anti-PD-1, (BMS-936558)
Bristol Myer Squib needs to show some compassion.
It is their ETHICAL Responsibility.
“It is not the strongest of the species that survives, nor the most intelligent, but the one most responsive to change.”
~Charles Darwin~
Take Care,
Jimmy B
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- June 18, 2012 at 3:02 pm
Will write soon as I finish this post.All of us together could maybe put some real pressure on Bristol Myers-Squibb.He needs our help.Invest a few minutes of your time to give him a shot at more time.Remember It could be you looking for some help.Pray he gets it. Al
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- June 18, 2012 at 3:02 pm
Will write soon as I finish this post.All of us together could maybe put some real pressure on Bristol Myers-Squibb.He needs our help.Invest a few minutes of your time to give him a shot at more time.Remember It could be you looking for some help.Pray he gets it. Al
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- June 18, 2012 at 3:02 pm
Will write soon as I finish this post.All of us together could maybe put some real pressure on Bristol Myers-Squibb.He needs our help.Invest a few minutes of your time to give him a shot at more time.Remember It could be you looking for some help.Pray he gets it. Al
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- June 18, 2012 at 3:38 pm
Will definitely write to Dr. at BMS today. There is also an online petition if you go to the video link Jimmy posted. Have tissues ready, very touching! Peace to all, Melissa
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- June 18, 2012 at 3:38 pm
Will definitely write to Dr. at BMS today. There is also an online petition if you go to the video link Jimmy posted. Have tissues ready, very touching! Peace to all, Melissa
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- June 18, 2012 at 3:38 pm
Will definitely write to Dr. at BMS today. There is also an online petition if you go to the video link Jimmy posted. Have tissues ready, very touching! Peace to all, Melissa
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- June 18, 2012 at 4:46 pm
So sad, hard to watch a child crying for his fathers life, I wrote to them also.
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- June 18, 2012 at 4:46 pm
So sad, hard to watch a child crying for his fathers life, I wrote to them also.
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- June 18, 2012 at 4:46 pm
So sad, hard to watch a child crying for his fathers life, I wrote to them also.
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- June 18, 2012 at 6:29 pm
Does anyone know why BMS will not give him the drug. I would like to make reference in my letter to "WHY" does he not qualify for the drug. I am assuming the the drug is anti-PD1. Is that correct?
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- June 18, 2012 at 7:11 pm
I assume he doesn't qualify for the clinical Trials of Anti-PD-1. His last resort would be a compassionate use of the drug. I believe BMS has not setup a compassionate use trial yet for this drug.
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- June 18, 2012 at 7:11 pm
I assume he doesn't qualify for the clinical Trials of Anti-PD-1. His last resort would be a compassionate use of the drug. I believe BMS has not setup a compassionate use trial yet for this drug.
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- June 18, 2012 at 7:11 pm
I assume he doesn't qualify for the clinical Trials of Anti-PD-1. His last resort would be a compassionate use of the drug. I believe BMS has not setup a compassionate use trial yet for this drug.
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- June 18, 2012 at 6:41 pm
Done! I hope BMS gets swamped with phone calls & emails.
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- June 18, 2012 at 6:41 pm
Done! I hope BMS gets swamped with phone calls & emails.
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- June 18, 2012 at 6:41 pm
Done! I hope BMS gets swamped with phone calls & emails.
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- June 18, 2012 at 6:53 pm
While I would like to help, I’m too busy trying to save my husbands life. He is also a father of three.-
- June 18, 2012 at 8:13 pm
Here is Darcy story from facebook.
Apparently he is disqualified from the drug because a brain met was found in his brain in April. You would think that he would have the brain met removed or zapped so that he could get the drug.
There are so many people looking to get into the BMS PD1 trial, I think that BMS is not ready to give the drug for "compassionate" use because many people need the PD1 drug and it is not proven safe yet. The FDA proabably would not let BMS give the drug out for "compassionate" useanyways. If BMS even wanted to give the drug out to "compassionate" use, it would take months for the FDA to approve the drug for compassionate use. This is such a sad story and effects all melanoma patients waiting to get into a PD1 trial not just Darcy.
http://www.facebook.com/HelpSaveDarcyNow/info
My name is Darcy Doherty. I am a 48 and father of Ganden, Reid and Cian. My family and I am are seeking compassionate access to a new cancer treatment in an attempt to extend my life. The experimental drug, BMS-936558, is in Phase 1 clinical trails at research locations in Canada and the U.S.A. In April, I was excluded from one because of new marginal cancer growth in my brain.
“Darcy has led a brave and heroic struggle against this disease for the past five years,” explains my wife, Rebecca Cumming. “And now, the kids and I are devastated that a promising drug is out there and proving successful in patients with Darcy’s diagnosis, yet we can’t get to it.”
Doherty’s oncologist, Dr. David Hogg, Attending Physician at Princess Margaret Hospital and Professor of Medicine at the University of Toronto, believes that his patient can benefit from this new treatment. “Mr. Doherty had a fantastic response to the then-experimental immunotherapy drug, ipilimumab (Yervoy®), in 2007. That drug has given him four years of life, and I believe that he may experience a similar benefit from BMS-936558.”
The manufacturer of Yervoy, Bristol-Myers Squibb whose Canadian head office is in Montréal, also produces this new drug. The company has repeatedly blocked Cumming’s appeals for access over the past weeks explaining that it does not have a compassionate use program.
“I respect the company’s trial criteria,” Cumming states, “but cannot accept that we are not able to get compassionate access to this potentially life-saving drug. We’ve all come so far and worked too hard to be prevented from this new treatment.”
Dr. Michael Giordano, Head of Development, Oncology and Immunosciences at Bristol-Myers Squibb explains his company’s position. “We strive to develop promising drugs as quickly as feasible while remaining mindful of protecting patient safety. [This drug] currently does not have an established benefit/risk profile, given [its] limited experience in humans. We are not in a position to allow [its] use outside of a highly controlled trial.”
For a devastated and discouraged Cumming, “it doesn't add up. Darcy has absolutely nothing to lose.” Given his previous success with immunotherapy when his brain cancer reduced significantly, “We see no risks at this point; without this drug he will die,” she declares.
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- June 18, 2012 at 8:13 pm
Here is Darcy story from facebook.
Apparently he is disqualified from the drug because a brain met was found in his brain in April. You would think that he would have the brain met removed or zapped so that he could get the drug.
There are so many people looking to get into the BMS PD1 trial, I think that BMS is not ready to give the drug for "compassionate" use because many people need the PD1 drug and it is not proven safe yet. The FDA proabably would not let BMS give the drug out for "compassionate" useanyways. If BMS even wanted to give the drug out to "compassionate" use, it would take months for the FDA to approve the drug for compassionate use. This is such a sad story and effects all melanoma patients waiting to get into a PD1 trial not just Darcy.
http://www.facebook.com/HelpSaveDarcyNow/info
My name is Darcy Doherty. I am a 48 and father of Ganden, Reid and Cian. My family and I am are seeking compassionate access to a new cancer treatment in an attempt to extend my life. The experimental drug, BMS-936558, is in Phase 1 clinical trails at research locations in Canada and the U.S.A. In April, I was excluded from one because of new marginal cancer growth in my brain.
“Darcy has led a brave and heroic struggle against this disease for the past five years,” explains my wife, Rebecca Cumming. “And now, the kids and I are devastated that a promising drug is out there and proving successful in patients with Darcy’s diagnosis, yet we can’t get to it.”
Doherty’s oncologist, Dr. David Hogg, Attending Physician at Princess Margaret Hospital and Professor of Medicine at the University of Toronto, believes that his patient can benefit from this new treatment. “Mr. Doherty had a fantastic response to the then-experimental immunotherapy drug, ipilimumab (Yervoy®), in 2007. That drug has given him four years of life, and I believe that he may experience a similar benefit from BMS-936558.”
The manufacturer of Yervoy, Bristol-Myers Squibb whose Canadian head office is in Montréal, also produces this new drug. The company has repeatedly blocked Cumming’s appeals for access over the past weeks explaining that it does not have a compassionate use program.
“I respect the company’s trial criteria,” Cumming states, “but cannot accept that we are not able to get compassionate access to this potentially life-saving drug. We’ve all come so far and worked too hard to be prevented from this new treatment.”
Dr. Michael Giordano, Head of Development, Oncology and Immunosciences at Bristol-Myers Squibb explains his company’s position. “We strive to develop promising drugs as quickly as feasible while remaining mindful of protecting patient safety. [This drug] currently does not have an established benefit/risk profile, given [its] limited experience in humans. We are not in a position to allow [its] use outside of a highly controlled trial.”
For a devastated and discouraged Cumming, “it doesn't add up. Darcy has absolutely nothing to lose.” Given his previous success with immunotherapy when his brain cancer reduced significantly, “We see no risks at this point; without this drug he will die,” she declares.
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- June 18, 2012 at 8:13 pm
Here is Darcy story from facebook.
Apparently he is disqualified from the drug because a brain met was found in his brain in April. You would think that he would have the brain met removed or zapped so that he could get the drug.
There are so many people looking to get into the BMS PD1 trial, I think that BMS is not ready to give the drug for "compassionate" use because many people need the PD1 drug and it is not proven safe yet. The FDA proabably would not let BMS give the drug out for "compassionate" useanyways. If BMS even wanted to give the drug out to "compassionate" use, it would take months for the FDA to approve the drug for compassionate use. This is such a sad story and effects all melanoma patients waiting to get into a PD1 trial not just Darcy.
http://www.facebook.com/HelpSaveDarcyNow/info
My name is Darcy Doherty. I am a 48 and father of Ganden, Reid and Cian. My family and I am are seeking compassionate access to a new cancer treatment in an attempt to extend my life. The experimental drug, BMS-936558, is in Phase 1 clinical trails at research locations in Canada and the U.S.A. In April, I was excluded from one because of new marginal cancer growth in my brain.
“Darcy has led a brave and heroic struggle against this disease for the past five years,” explains my wife, Rebecca Cumming. “And now, the kids and I are devastated that a promising drug is out there and proving successful in patients with Darcy’s diagnosis, yet we can’t get to it.”
Doherty’s oncologist, Dr. David Hogg, Attending Physician at Princess Margaret Hospital and Professor of Medicine at the University of Toronto, believes that his patient can benefit from this new treatment. “Mr. Doherty had a fantastic response to the then-experimental immunotherapy drug, ipilimumab (Yervoy®), in 2007. That drug has given him four years of life, and I believe that he may experience a similar benefit from BMS-936558.”
The manufacturer of Yervoy, Bristol-Myers Squibb whose Canadian head office is in Montréal, also produces this new drug. The company has repeatedly blocked Cumming’s appeals for access over the past weeks explaining that it does not have a compassionate use program.
“I respect the company’s trial criteria,” Cumming states, “but cannot accept that we are not able to get compassionate access to this potentially life-saving drug. We’ve all come so far and worked too hard to be prevented from this new treatment.”
Dr. Michael Giordano, Head of Development, Oncology and Immunosciences at Bristol-Myers Squibb explains his company’s position. “We strive to develop promising drugs as quickly as feasible while remaining mindful of protecting patient safety. [This drug] currently does not have an established benefit/risk profile, given [its] limited experience in humans. We are not in a position to allow [its] use outside of a highly controlled trial.”
For a devastated and discouraged Cumming, “it doesn't add up. Darcy has absolutely nothing to lose.” Given his previous success with immunotherapy when his brain cancer reduced significantly, “We see no risks at this point; without this drug he will die,” she declares.
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- June 18, 2012 at 6:53 pm
While I would like to help, I’m too busy trying to save my husbands life. He is also a father of three. -
- June 18, 2012 at 6:53 pm
While I would like to help, I’m too busy trying to save my husbands life. He is also a father of three. -
- June 18, 2012 at 8:05 pm
Jimmy,
You are always so helpful to others. I signed it and feel so bad for this family but also know the feeling walking in their shoes with little ones and a stage IV husband. I hope one day soon we won't have to fear this stupid cancer.
Thanks,
Rebecca
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- June 18, 2012 at 8:05 pm
Jimmy,
You are always so helpful to others. I signed it and feel so bad for this family but also know the feeling walking in their shoes with little ones and a stage IV husband. I hope one day soon we won't have to fear this stupid cancer.
Thanks,
Rebecca
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- June 18, 2012 at 8:05 pm
Jimmy,
You are always so helpful to others. I signed it and feel so bad for this family but also know the feeling walking in their shoes with little ones and a stage IV husband. I hope one day soon we won't have to fear this stupid cancer.
Thanks,
Rebecca
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- June 18, 2012 at 10:27 pm
Jimmy, Why can't he get the brain met zapped? If that is the only reason then his doctor should have taken care of it. Has his doctor also tested him to see if he has PDL1? They have some idea that if you have it, Anti PD 1 will work and if you don't, it probably won't. It would be awful if he is waiting for compassionate use and then find out it wouldn't benefit him…They are checking the melanoma samples of those of us ( about 110 of us) now who are in the Anti pPD1 trial to see who has PDL1. -Lynn
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- June 18, 2012 at 10:27 pm
Jimmy, Why can't he get the brain met zapped? If that is the only reason then his doctor should have taken care of it. Has his doctor also tested him to see if he has PDL1? They have some idea that if you have it, Anti PD 1 will work and if you don't, it probably won't. It would be awful if he is waiting for compassionate use and then find out it wouldn't benefit him…They are checking the melanoma samples of those of us ( about 110 of us) now who are in the Anti pPD1 trial to see who has PDL1. -Lynn
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- June 18, 2012 at 10:27 pm
Jimmy, Why can't he get the brain met zapped? If that is the only reason then his doctor should have taken care of it. Has his doctor also tested him to see if he has PDL1? They have some idea that if you have it, Anti PD 1 will work and if you don't, it probably won't. It would be awful if he is waiting for compassionate use and then find out it wouldn't benefit him…They are checking the melanoma samples of those of us ( about 110 of us) now who are in the Anti pPD1 trial to see who has PDL1. -Lynn
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- June 18, 2012 at 10:42 pm
Lynn,
I don't have Darcey's medical records, so I don't know twhat he has done and what tests were run. I can only hope that his oncologist is on top of everything. He is being treated in Toronto, Canada , not in the US.
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- June 18, 2012 at 10:42 pm
Lynn,
I don't have Darcey's medical records, so I don't know twhat he has done and what tests were run. I can only hope that his oncologist is on top of everything. He is being treated in Toronto, Canada , not in the US.
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- June 18, 2012 at 10:42 pm
Lynn,
I don't have Darcey's medical records, so I don't know twhat he has done and what tests were run. I can only hope that his oncologist is on top of everything. He is being treated in Toronto, Canada , not in the US.
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- June 19, 2012 at 12:20 am
Hi,
I have posted also, thank you. I hope it helps. melanoma is such a horrible disease .
laurie from maine
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- June 19, 2012 at 12:20 am
Hi,
I have posted also, thank you. I hope it helps. melanoma is such a horrible disease .
laurie from maine
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- June 19, 2012 at 12:20 am
Hi,
I have posted also, thank you. I hope it helps. melanoma is such a horrible disease .
laurie from maine
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- June 21, 2012 at 4:29 pm
I think that there are a number of melanoma patients trying to get in PD1 trials. I am sorry that Darcy is having problems but to be fair, I think that his case is no different then others trying to get into the PD1 trials.
I read that her took yervoy/ipi 5 years ago and he was a responder. Why wouldn't Darcy get a re-induction of Yervoy at least to try to save his life or take care of the met in his brain then he would qualify for more trials including pd1.
Just my 2 cents!
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- June 21, 2012 at 4:29 pm
I think that there are a number of melanoma patients trying to get in PD1 trials. I am sorry that Darcy is having problems but to be fair, I think that his case is no different then others trying to get into the PD1 trials.
I read that her took yervoy/ipi 5 years ago and he was a responder. Why wouldn't Darcy get a re-induction of Yervoy at least to try to save his life or take care of the met in his brain then he would qualify for more trials including pd1.
Just my 2 cents!
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- June 21, 2012 at 4:29 pm
I think that there are a number of melanoma patients trying to get in PD1 trials. I am sorry that Darcy is having problems but to be fair, I think that his case is no different then others trying to get into the PD1 trials.
I read that her took yervoy/ipi 5 years ago and he was a responder. Why wouldn't Darcy get a re-induction of Yervoy at least to try to save his life or take care of the met in his brain then he would qualify for more trials including pd1.
Just my 2 cents!
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- June 22, 2012 at 12:50 am
hi..
I never give up in leading people to investigate Cellect… please check it out.. i have been reading about it.. my daughter is on it and is having amazing results…
there is a facebook page on this as well… it is national cancer research foundation… there are testimonials that are mindblowing… this is a supplement.. and is curing cancer!!! brain tumors disappearing.. all kinds of things going away. cancerous and non….
if i were in Darcy's position.. the first thing i would do is go to http://www.ncrg.org.. and get on the phone with Fred Eichorn.. who developed it after curing himself of pancreatic cancer… he then went on to get his degree as a transplant dr.. as well as a bio-chemist…
it seems no one believes… but still i put it out there for you… just in case you are one person who will check this out!!!
good luck to Darcy..
xx
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- June 22, 2012 at 12:50 am
hi..
I never give up in leading people to investigate Cellect… please check it out.. i have been reading about it.. my daughter is on it and is having amazing results…
there is a facebook page on this as well… it is national cancer research foundation… there are testimonials that are mindblowing… this is a supplement.. and is curing cancer!!! brain tumors disappearing.. all kinds of things going away. cancerous and non….
if i were in Darcy's position.. the first thing i would do is go to http://www.ncrg.org.. and get on the phone with Fred Eichorn.. who developed it after curing himself of pancreatic cancer… he then went on to get his degree as a transplant dr.. as well as a bio-chemist…
it seems no one believes… but still i put it out there for you… just in case you are one person who will check this out!!!
good luck to Darcy..
xx
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- June 22, 2012 at 12:50 am
hi..
I never give up in leading people to investigate Cellect… please check it out.. i have been reading about it.. my daughter is on it and is having amazing results…
there is a facebook page on this as well… it is national cancer research foundation… there are testimonials that are mindblowing… this is a supplement.. and is curing cancer!!! brain tumors disappearing.. all kinds of things going away. cancerous and non….
if i were in Darcy's position.. the first thing i would do is go to http://www.ncrg.org.. and get on the phone with Fred Eichorn.. who developed it after curing himself of pancreatic cancer… he then went on to get his degree as a transplant dr.. as well as a bio-chemist…
it seems no one believes… but still i put it out there for you… just in case you are one person who will check this out!!!
good luck to Darcy..
xx
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- June 22, 2012 at 12:52 am
hi..
I never give up in leading people to investigate Collect… please check it out.. i have been reading about it.. my daughter is on it and is having amazing results…
there is a Facebook page on this as well… it is national cancer research foundation… there are testimonials that are mindblowing… this is a supplement.. and is curing cancer!!! brain tumors disappearing.. all kinds of things going away. cancerous and non….
if i were in Darcy's position.. the first thing i would do is go to http://www.ncrf.organd get on the phone with Fred Eichorn.. who developed it after curing himself of pancreatic cancer… he then went on to get his degree as a transplant dr.. as well as a bio-chemist…
it seems no one believes… but still i put it out there for you… just in case you are one person who will check this out!!!
good luck to Darcy..
xx
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- July 27, 2012 at 12:31 am
Darcy died on July 10th. It appears BMS did not give him the drug!!!
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- July 27, 2012 at 12:31 am
Darcy died on July 10th. It appears BMS did not give him the drug!!!
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- July 27, 2012 at 12:31 am
Darcy died on July 10th. It appears BMS did not give him the drug!!!
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- June 22, 2012 at 12:52 am
hi..
I never give up in leading people to investigate Collect… please check it out.. i have been reading about it.. my daughter is on it and is having amazing results…
there is a Facebook page on this as well… it is national cancer research foundation… there are testimonials that are mindblowing… this is a supplement.. and is curing cancer!!! brain tumors disappearing.. all kinds of things going away. cancerous and non….
if i were in Darcy's position.. the first thing i would do is go to http://www.ncrf.organd get on the phone with Fred Eichorn.. who developed it after curing himself of pancreatic cancer… he then went on to get his degree as a transplant dr.. as well as a bio-chemist…
it seems no one believes… but still i put it out there for you… just in case you are one person who will check this out!!!
good luck to Darcy..
xx
-
- June 22, 2012 at 12:52 am
hi..
I never give up in leading people to investigate Collect… please check it out.. i have been reading about it.. my daughter is on it and is having amazing results…
there is a Facebook page on this as well… it is national cancer research foundation… there are testimonials that are mindblowing… this is a supplement.. and is curing cancer!!! brain tumors disappearing.. all kinds of things going away. cancerous and non….
if i were in Darcy's position.. the first thing i would do is go to http://www.ncrf.organd get on the phone with Fred Eichorn.. who developed it after curing himself of pancreatic cancer… he then went on to get his degree as a transplant dr.. as well as a bio-chemist…
it seems no one believes… but still i put it out there for you… just in case you are one person who will check this out!!!
good luck to Darcy..
xx
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