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Re: Recurrences with brain mets from BRAF/MEK Drugs?

Forums General Melanoma Community Recurrences with brain mets from BRAF/MEK Drugs? Re: Recurrences with brain mets from BRAF/MEK Drugs?

    Jim in Denver

      Hi Sharon,

      If you have the V600e, you should consider the BRAF Inhibitor first.  Wild Type would not be the V600e – sometime a re-test will show it (if it is present) because of uneven distribution of the gene in the sample, but that is uncommon apparently.  It would be a good choice to have, I think.  I tested negative for the 600e (g and k as well), so I am doing the Ipi/Temador Trial at MD Anderson.  Yesterday, there was national news item about a future trial combining the BRAF Inhibitor with Ipi, which will doubtless happen at some point, but maybe not soon enough for your decision.  You have probably already read/heard about response durability issues with the BRAF Inhibitor(s).  Maybe you should ask your Onc if you can do the Compassionate Use IPI Trial regardless of your response to a BRAF Inhibitor – what do you think?



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