The most important new drug of 2015? :)
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The most important new drug of 2015? :)

› Forums › General Melanoma Community › The most important new drug of 2015? :)

  • Post
    • January 5, 2015 at 12:59 pm
    rick1981
    Participant

    ….panRAF inhibitors.

    Stage 1 trials just starting. These pills seems similar to BRAF/MEK in attacking proteins but use multiple paths making them potentially impossible to become resistent too. Promising!

    (I can't paste the link unfortunately, anyone else having issues pasting text on MPIP?!)

     

Viewing 14 reply threads
  • Replies
      • January 5, 2015 at 2:48 pm
      Wader
      Participant

      Are there trials in the US? From what I read trials are offered in the UK.

      Hope there will be some in the US.

      • January 5, 2015 at 2:48 pm
      Wader
      Participant

      Are there trials in the US? From what I read trials are offered in the UK.

      Hope there will be some in the US.

        • January 6, 2015 at 7:56 am
        rick1981
        Participant

        There is a trial open, can't paste the link as usual but it's called LY3009120 on the clinicaltrials.gov website. The company behind the drug is Eli Lilly (?).

        They are recruiting in Boston, Scotsdale AZ and Houston.

        • January 6, 2015 at 7:56 am
        rick1981
        Participant

        There is a trial open, can't paste the link as usual but it's called LY3009120 on the clinicaltrials.gov website. The company behind the drug is Eli Lilly (?).

        They are recruiting in Boston, Scotsdale AZ and Houston.

        • January 6, 2015 at 7:56 am
        rick1981
        Participant

        There is a trial open, can't paste the link as usual but it's called LY3009120 on the clinicaltrials.gov website. The company behind the drug is Eli Lilly (?).

        They are recruiting in Boston, Scotsdale AZ and Houston.

        • January 7, 2015 at 9:07 am
        rick1981
        Participant

        The trial in the UK (different one it seems) will be in the Royal Marsden in London and the Christie Hospital in Manchester – recruitment hasn't started yet.

        • January 7, 2015 at 9:07 am
        rick1981
        Participant

        The trial in the UK (different one it seems) will be in the Royal Marsden in London and the Christie Hospital in Manchester – recruitment hasn't started yet.

        • January 7, 2015 at 9:07 am
        rick1981
        Participant

        The trial in the UK (different one it seems) will be in the Royal Marsden in London and the Christie Hospital in Manchester – recruitment hasn't started yet.

      • January 5, 2015 at 2:48 pm
      Wader
      Participant

      Are there trials in the US? From what I read trials are offered in the UK.

      Hope there will be some in the US.

      • January 5, 2015 at 7:26 pm
      arthurjedi007
      Participant

      http://www.dailymail.co.uk/health/article-2894612/Revolutionary-new-PILL-treat-skin-cancer-Scientists-discover-drug-help-patients-resistant-standard-treatments.html

      Sounds fantastic. Hope it works. Also for the 30%ish of us that are B-RAF positive but B-RAF doesn't work I hope this works.

      Thanks Rick.

      Artie

      • January 5, 2015 at 7:26 pm
      arthurjedi007
      Participant

      http://www.dailymail.co.uk/health/article-2894612/Revolutionary-new-PILL-treat-skin-cancer-Scientists-discover-drug-help-patients-resistant-standard-treatments.html

      Sounds fantastic. Hope it works. Also for the 30%ish of us that are B-RAF positive but B-RAF doesn't work I hope this works.

      Thanks Rick.

      Artie

      • January 5, 2015 at 7:26 pm
      arthurjedi007
      Participant

      http://www.dailymail.co.uk/health/article-2894612/Revolutionary-new-PILL-treat-skin-cancer-Scientists-discover-drug-help-patients-resistant-standard-treatments.html

      Sounds fantastic. Hope it works. Also for the 30%ish of us that are B-RAF positive but B-RAF doesn't work I hope this works.

      Thanks Rick.

      Artie

      • January 5, 2015 at 11:29 pm
      Ninniditti
      Participant
      Hi!
      I have read the linked page but don't understand if the new drug only works if you are BRAF positive. 
      • January 5, 2015 at 11:29 pm
      Ninniditti
      Participant
      Hi!
      I have read the linked page but don't understand if the new drug only works if you are BRAF positive. 
        • January 6, 2015 at 1:31 am
        arthurjedi007
        Participant

        Good question. I don't understand either.

        Artie

        • January 6, 2015 at 1:31 am
        arthurjedi007
        Participant

        Good question. I don't understand either.

        Artie

        • January 6, 2015 at 1:31 am
        arthurjedi007
        Participant

        Good question. I don't understand either.

        Artie

      • January 5, 2015 at 11:29 pm
      Ninniditti
      Participant
      Hi!
      I have read the linked page but don't understand if the new drug only works if you are BRAF positive. 
      • January 6, 2015 at 1:53 am
      Bubbles
      Participant

      PAN raf…..means that.  Covering a wide range of pathways….in theory…BRAF, NRAS, etc. Of course, time will tell. The downside may be that while they cover a greater range of pathways, they may induce a greater range of side effects as well. Of course, time will tell and we can hope.

      PS….to post a link? Easy peasy. Use the "chain link" icon.

      Here's to many new things and wonderful breakthroughs in 2015! C

      • January 6, 2015 at 1:53 am
      Bubbles
      Participant

      PAN raf…..means that.  Covering a wide range of pathways….in theory…BRAF, NRAS, etc. Of course, time will tell. The downside may be that while they cover a greater range of pathways, they may induce a greater range of side effects as well. Of course, time will tell and we can hope.

      PS….to post a link? Easy peasy. Use the "chain link" icon.

      Here's to many new things and wonderful breakthroughs in 2015! C

      • January 6, 2015 at 1:53 am
      Bubbles
      Participant

      PAN raf…..means that.  Covering a wide range of pathways….in theory…BRAF, NRAS, etc. Of course, time will tell. The downside may be that while they cover a greater range of pathways, they may induce a greater range of side effects as well. Of course, time will tell and we can hope.

      PS….to post a link? Easy peasy. Use the "chain link" icon.

      Here's to many new things and wonderful breakthroughs in 2015! C

        • January 6, 2015 at 7:46 am
        rick1981
        Participant

        (Neither the good ol' copy-paste or the chain thingy work for me somehow – must be my old browser)

        • January 6, 2015 at 7:46 am
        rick1981
        Participant

        (Neither the good ol' copy-paste or the chain thingy work for me somehow – must be my old browser)

        • January 6, 2015 at 7:46 am
        rick1981
        Participant

        (Neither the good ol' copy-paste or the chain thingy work for me somehow – must be my old browser)

        • January 6, 2015 at 11:38 am
        rick1981
        Participant

        On the side effects, for what it's worth: "the two drugs were effective at stopping drug-resistant tumors in mice without any accompanying serious side-effects".

        • January 6, 2015 at 11:38 am
        rick1981
        Participant

        On the side effects, for what it's worth: "the two drugs were effective at stopping drug-resistant tumors in mice without any accompanying serious side-effects".

        • January 6, 2015 at 11:38 am
        rick1981
        Participant

        On the side effects, for what it's worth: "the two drugs were effective at stopping drug-resistant tumors in mice without any accompanying serious side-effects".

      • January 29, 2015 at 10:54 am
      rick1981
      Participant

      Any news on the panRAF inhibitors? Is anyone on MPIP participating in a trial or planning to?

      • January 29, 2015 at 10:54 am
      rick1981
      Participant

      Any news on the panRAF inhibitors? Is anyone on MPIP participating in a trial or planning to?

        • January 13, 2016 at 7:39 am
        Hibby1975
        Participant

        My husband has just started a phase 1 pan raf trial (millennium). He is struggling with some of the side effects, fatigue, joint pain and nausea. He has only had his second dose so far and he doesn't have a scan until March. It would be interesting to know if anyone has heard any more about pan raf or if anyone else is on the trial. 

        We are based in the uk.

        • January 13, 2016 at 7:39 am
        Hibby1975
        Participant

        My husband has just started a phase 1 pan raf trial (millennium). He is struggling with some of the side effects, fatigue, joint pain and nausea. He has only had his second dose so far and he doesn't have a scan until March. It would be interesting to know if anyone has heard any more about pan raf or if anyone else is on the trial. 

        We are based in the uk.

        • January 13, 2016 at 7:39 am
        Hibby1975
        Participant

        My husband has just started a phase 1 pan raf trial (millennium). He is struggling with some of the side effects, fatigue, joint pain and nausea. He has only had his second dose so far and he doesn't have a scan until March. It would be interesting to know if anyone has heard any more about pan raf or if anyone else is on the trial. 

        We are based in the uk.

      • January 29, 2015 at 10:54 am
      rick1981
      Participant

      Any news on the panRAF inhibitors? Is anyone on MPIP participating in a trial or planning to?

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