› Forums › General Melanoma Community › Human cancer prognosis is related to newly identified immune cell
- This topic has 3 replies, 1 voice, and was last updated 11 years, 6 months ago by
Brent Morris.
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- October 16, 2014 at 8:09 pm
No specific mention of melanoma in this article but seems like it would be applicable. Hopefully something like this will prove beneficial in combination with the already existing immunotherapies.
http://medicalxpress.com/news/2014-10-human-cancer-prognosis-newly-immune.html
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- October 17, 2014 at 6:04 pm
Dear Brian Maybe this is one more piece of the puzzle. Here is some background on the dendritic cells referred to in the article.
Immunol Rev. 2010 Mar;234(1):268-81. doi: 10.1111/j.0105-2896.2009.00874.x.Development and functional specialization of CD103+ dendritic cells.
Abstract
CD103 (alpha(E)) integrin expression distinguishes a population of dendritic cells (DCs) that can be found in many if not all lymphoid and non-lymphoid organs. CD103(+) DCs display distinct functional activities. Migratory CD103(+) DCs derived from skin, lung, and intestine efficiently present exogenous antigens in their corresponding draining lymph nodes to specific CD8(+) T cells through a mechanism known as cross-presentation. On the T cells they prime, intestinal CD103(+) DCs can drive the induction of the chemokine receptor CCR9 and alpha(4)beta(7) integrin, both known as gut-homing receptors. CD103(+) DCs also contribute to control inflammatory responses and intestinal homeostasis by fostering the conversion of naive T cells into induced Foxp3(+) regulatory T cells, a mechanism that relies on transforming growth factor-beta and retinoic acid signaling. This review discusses recent findings that identify murine CD103(+) DCs as important regulators of the immune response.
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- October 17, 2014 at 6:04 pm
Dear Brian Maybe this is one more piece of the puzzle. Here is some background on the dendritic cells referred to in the article.
Immunol Rev. 2010 Mar;234(1):268-81. doi: 10.1111/j.0105-2896.2009.00874.x.Development and functional specialization of CD103+ dendritic cells.
Abstract
CD103 (alpha(E)) integrin expression distinguishes a population of dendritic cells (DCs) that can be found in many if not all lymphoid and non-lymphoid organs. CD103(+) DCs display distinct functional activities. Migratory CD103(+) DCs derived from skin, lung, and intestine efficiently present exogenous antigens in their corresponding draining lymph nodes to specific CD8(+) T cells through a mechanism known as cross-presentation. On the T cells they prime, intestinal CD103(+) DCs can drive the induction of the chemokine receptor CCR9 and alpha(4)beta(7) integrin, both known as gut-homing receptors. CD103(+) DCs also contribute to control inflammatory responses and intestinal homeostasis by fostering the conversion of naive T cells into induced Foxp3(+) regulatory T cells, a mechanism that relies on transforming growth factor-beta and retinoic acid signaling. This review discusses recent findings that identify murine CD103(+) DCs as important regulators of the immune response.
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- October 17, 2014 at 6:04 pm
Dear Brian Maybe this is one more piece of the puzzle. Here is some background on the dendritic cells referred to in the article.
Immunol Rev. 2010 Mar;234(1):268-81. doi: 10.1111/j.0105-2896.2009.00874.x.Development and functional specialization of CD103+ dendritic cells.
Abstract
CD103 (alpha(E)) integrin expression distinguishes a population of dendritic cells (DCs) that can be found in many if not all lymphoid and non-lymphoid organs. CD103(+) DCs display distinct functional activities. Migratory CD103(+) DCs derived from skin, lung, and intestine efficiently present exogenous antigens in their corresponding draining lymph nodes to specific CD8(+) T cells through a mechanism known as cross-presentation. On the T cells they prime, intestinal CD103(+) DCs can drive the induction of the chemokine receptor CCR9 and alpha(4)beta(7) integrin, both known as gut-homing receptors. CD103(+) DCs also contribute to control inflammatory responses and intestinal homeostasis by fostering the conversion of naive T cells into induced Foxp3(+) regulatory T cells, a mechanism that relies on transforming growth factor-beta and retinoic acid signaling. This review discusses recent findings that identify murine CD103(+) DCs as important regulators of the immune response.
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