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rash

› Forums › General Melanoma Community › rash

  • Post
    • June 9, 2013 at 8:42 pm
    Wolfie
    Participant

    Severe body rash after5 days on full dose Zelboraf. Stopped x 1week, resumed half dose. Rash continued, low grade temp., swollen knuckles. Had to stop again. Anyone had similar experience? Able to stay on Zelboraf? Anyone try prednisone or other treatment? Thanks in advance, Jean

    Severe body rash after5 days on full dose Zelboraf. Stopped x 1week, resumed half dose. Rash continued, low grade temp., swollen knuckles. Had to stop again. Anyone had similar experience? Able to stay on Zelboraf? Anyone try prednisone or other treatment? Thanks in advance, Jean

Viewing 11 reply threads
  • Replies
      • June 9, 2013 at 9:45 pm
      awillett1991
      Participant
      I was on a reduced dose of Zel – 6 pills a day, plus prednisone for rash and many other side effects. Got a year out of it this way.
      • June 9, 2013 at 9:45 pm
      awillett1991
      Participant
      I was on a reduced dose of Zel – 6 pills a day, plus prednisone for rash and many other side effects. Got a year out of it this way.
      • June 9, 2013 at 9:45 pm
      awillett1991
      Participant
      I was on a reduced dose of Zel – 6 pills a day, plus prednisone for rash and many other side effects. Got a year out of it this way.
      • June 10, 2013 at 5:28 pm
      Tim–MRF
      Guest

      Some studies have shown that combining a BRAF inhibitor like Zelboraf with a MEK inhibitor reduces a number of side effects, including rash.  You may want to speak with your doctor about this.  A MEK inhibitor was approved by the FDA a few days ago, under the trade name Mekinist.

      Tim–MRF

      • June 10, 2013 at 5:28 pm
      Tim–MRF
      Guest

      Some studies have shown that combining a BRAF inhibitor like Zelboraf with a MEK inhibitor reduces a number of side effects, including rash.  You may want to speak with your doctor about this.  A MEK inhibitor was approved by the FDA a few days ago, under the trade name Mekinist.

      Tim–MRF

      • June 10, 2013 at 5:28 pm
      Tim–MRF
      Guest

      Some studies have shown that combining a BRAF inhibitor like Zelboraf with a MEK inhibitor reduces a number of side effects, including rash.  You may want to speak with your doctor about this.  A MEK inhibitor was approved by the FDA a few days ago, under the trade name Mekinist.

      Tim–MRF

      • June 13, 2013 at 12:13 am
      joycedixon
      Participant

      I have been on 4 times 4 tablets per day for almost 3 months.For about a month I had severe joint pain.

      I soon realized that the pain came  from stressing a joint-Normally it would not have caused pain but my super charged 

      immune system over reacted.. I move carefully in the house –no scrubbing the floor on hands and knees.I no longer lift

      toddlers or heavy boxes. The past few weeks I have felt fairly normal–my hands are still swollen some and I do not

      do repetitious tasks with them(no peeling potatoes)  I feel  I am getting used  to the zelboraf which was a little

      scarey.However,my dermatologist said the medicine was still working and you did not have to continually suffer

      for it to be effective. So  treat your body kindly and maybe the side effects will lessen.

       

      • June 13, 2013 at 12:13 am
      joycedixon
      Participant

      I have been on 4 times 4 tablets per day for almost 3 months.For about a month I had severe joint pain.

      I soon realized that the pain came  from stressing a joint-Normally it would not have caused pain but my super charged 

      immune system over reacted.. I move carefully in the house –no scrubbing the floor on hands and knees.I no longer lift

      toddlers or heavy boxes. The past few weeks I have felt fairly normal–my hands are still swollen some and I do not

      do repetitious tasks with them(no peeling potatoes)  I feel  I am getting used  to the zelboraf which was a little

      scarey.However,my dermatologist said the medicine was still working and you did not have to continually suffer

      for it to be effective. So  treat your body kindly and maybe the side effects will lessen.

       

      • June 13, 2013 at 12:13 am
      joycedixon
      Participant

      I have been on 4 times 4 tablets per day for almost 3 months.For about a month I had severe joint pain.

      I soon realized that the pain came  from stressing a joint-Normally it would not have caused pain but my super charged 

      immune system over reacted.. I move carefully in the house –no scrubbing the floor on hands and knees.I no longer lift

      toddlers or heavy boxes. The past few weeks I have felt fairly normal–my hands are still swollen some and I do not

      do repetitious tasks with them(no peeling potatoes)  I feel  I am getting used  to the zelboraf which was a little

      scarey.However,my dermatologist said the medicine was still working and you did not have to continually suffer

      for it to be effective. So  treat your body kindly and maybe the side effects will lessen.

       

      • June 13, 2013 at 12:15 am
      joycedixon
      Participant

      I have been on 4 times 4 tablets per day for almost 3 months.For about a month I had severe joint pain.

      I soon realized that the pain came  from stressing a joint-Normally it would not have caused pain but my super charged 

      immune system over reacted.. I move carefully in the house –no scrubbing the floor on hands and knees.I no longer lift

      toddlers or heavy boxes. The past few weeks I have felt fairly normal–my hands are still swollen some and I do not

      do repetitious tasks with them(no peeling potatoes)  I feel  I am getting used  to the zelboraf which was a little

      scarey.However,my dermatologist said the medicine was still working and you did not have to continually suffer

      for it to be effective. So  treat your body kindly and maybe the side effects will lessen.

      • June 13, 2013 at 12:15 am
      joycedixon
      Participant

      I have been on 4 times 4 tablets per day for almost 3 months.For about a month I had severe joint pain.

      I soon realized that the pain came  from stressing a joint-Normally it would not have caused pain but my super charged 

      immune system over reacted.. I move carefully in the house –no scrubbing the floor on hands and knees.I no longer lift

      toddlers or heavy boxes. The past few weeks I have felt fairly normal–my hands are still swollen some and I do not

      do repetitious tasks with them(no peeling potatoes)  I feel  I am getting used  to the zelboraf which was a little

      scarey.However,my dermatologist said the medicine was still working and you did not have to continually suffer

      for it to be effective. So  treat your body kindly and maybe the side effects will lessen.

      • June 13, 2013 at 12:15 am
      joycedixon
      Participant

      I have been on 4 times 4 tablets per day for almost 3 months.For about a month I had severe joint pain.

      I soon realized that the pain came  from stressing a joint-Normally it would not have caused pain but my super charged 

      immune system over reacted.. I move carefully in the house –no scrubbing the floor on hands and knees.I no longer lift

      toddlers or heavy boxes. The past few weeks I have felt fairly normal–my hands are still swollen some and I do not

      do repetitious tasks with them(no peeling potatoes)  I feel  I am getting used  to the zelboraf which was a little

      scarey.However,my dermatologist said the medicine was still working and you did not have to continually suffer

      for it to be effective. So  treat your body kindly and maybe the side effects will lessen.

Viewing 11 reply threads
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