“Required” Scans for Merck , BMS, GSK & other trials!
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“Required” Scans for Merck , BMS, GSK & other trials!

› Forums › General Melanoma Community › “Required” Scans for Merck , BMS, GSK & other trials!

  • Post
    • September 1, 2012 at 11:09 pm
    killmel
    Participant

    Hi All,

    I am new to the board. I feel very lucky I found you all.

    I am wondering what parts of the body are required to be scanned for clinical trials. Is it required for trials to scan from head to toe???

    I am in  Merck PD1 clinical trial and have scans every 12 weeks.  These are the scans I am getting: MRI Brain, CT Neck, Ct Chest, CT Abdomen & Pelvis, plus lower extremties because in the past, I had tumors in my left leg, lungs, and on chest. Recently, just became NED. 

    Hi All,

    I am new to the board. I feel very lucky I found you all.

    I am wondering what parts of the body are required to be scanned for clinical trials. Is it required for trials to scan from head to toe???

    I am in  Merck PD1 clinical trial and have scans every 12 weeks.  These are the scans I am getting: MRI Brain, CT Neck, Ct Chest, CT Abdomen & Pelvis, plus lower extremties because in the past, I had tumors in my left leg, lungs, and on chest. Recently, just became NED. 

    I would appreciate you sharing what trial/and or sponsor of the trial and what scans are you required to have??

    Thank so much for replying to my post.

    God Bless you all.

    Marybelle

Viewing 8 reply threads
  • Replies
      • September 2, 2012 at 2:47 am
      rbruce
      Participant

      Marybelle, first of all, I have to ask, how did you become NED? Is it from the trial or did you havevsurgical resection?  I too am on the Merck Anti-Pd1 trial (see my earlier post).  i get the full head to toe pet/ct every 12 weeks. Haven't had a brain MRI since the start of my trial 24 weeks ago.  Robert 

        • September 2, 2012 at 8:24 pm
        killmel
        Participant

        Hi Robert,

        Yes, I did become NED while on the trial. I had active tumors at the start of the trial. I predict  that you too will become NED on your next set of scans.

        What kind of side effects do you have? I lost my thyroid function plus joint/muscle pain and rash.

        We have about 20 patients on this trial. Only a few are not responding. How many patients are in your trial???Are any of them not responding???

        There are no more openings at our site for this trial??? Any seats at  UCSF? My friend is trying to get into this trial.

        Best wishes to you.

        Marybelle

        • September 2, 2012 at 8:57 pm
        rbruce
        Participant

        Marybelle,

        What kind of tumors did you have when you started, ie. locations?  I sm so excited for you and all of us that are responding to this therapy.  My side effects have been an upper chest rash, muscle, joint and bone aches and pains and fatigue.  But, like I've said in other posts, since I did biochemo first, everything else has been a cakewalk.  We started with 4 in our UCSF trial and they added 3 who had already done Yervoy. I do not believe there are any open seats as I was told a "clinic in Southern California took too many seats".   2 participants are out as having 0 response and am being told that I have had the best response of the group so far at UCSF.  I attribute that to the fact that my tumors must have expressed the PD ligand.  BMS's trial shows 29 to 41% response when pd ligand is expressed and 0% when not.  This is our BRAF moment cuz up until now BRAF negatives had nothing showing a good response.  Yervoy is marginal at best, and the side effects quite daunting but it's all we had until this discovery.  

        Thanks for the encouraging words for my next scans at 36 weeks. For the first time in a year and a half I BELIEVE that I am going to beat this monster.  

        Robert

        • September 2, 2012 at 8:57 pm
        rbruce
        Participant

        Marybelle,

        What kind of tumors did you have when you started, ie. locations?  I sm so excited for you and all of us that are responding to this therapy.  My side effects have been an upper chest rash, muscle, joint and bone aches and pains and fatigue.  But, like I've said in other posts, since I did biochemo first, everything else has been a cakewalk.  We started with 4 in our UCSF trial and they added 3 who had already done Yervoy. I do not believe there are any open seats as I was told a "clinic in Southern California took too many seats".   2 participants are out as having 0 response and am being told that I have had the best response of the group so far at UCSF.  I attribute that to the fact that my tumors must have expressed the PD ligand.  BMS's trial shows 29 to 41% response when pd ligand is expressed and 0% when not.  This is our BRAF moment cuz up until now BRAF negatives had nothing showing a good response.  Yervoy is marginal at best, and the side effects quite daunting but it's all we had until this discovery.  

        Thanks for the encouraging words for my next scans at 36 weeks. For the first time in a year and a half I BELIEVE that I am going to beat this monster.  

        Robert

        • September 2, 2012 at 8:57 pm
        rbruce
        Participant

        Marybelle,

        What kind of tumors did you have when you started, ie. locations?  I sm so excited for you and all of us that are responding to this therapy.  My side effects have been an upper chest rash, muscle, joint and bone aches and pains and fatigue.  But, like I've said in other posts, since I did biochemo first, everything else has been a cakewalk.  We started with 4 in our UCSF trial and they added 3 who had already done Yervoy. I do not believe there are any open seats as I was told a "clinic in Southern California took too many seats".   2 participants are out as having 0 response and am being told that I have had the best response of the group so far at UCSF.  I attribute that to the fact that my tumors must have expressed the PD ligand.  BMS's trial shows 29 to 41% response when pd ligand is expressed and 0% when not.  This is our BRAF moment cuz up until now BRAF negatives had nothing showing a good response.  Yervoy is marginal at best, and the side effects quite daunting but it's all we had until this discovery.  

        Thanks for the encouraging words for my next scans at 36 weeks. For the first time in a year and a half I BELIEVE that I am going to beat this monster.  

        Robert

        • September 2, 2012 at 8:24 pm
        killmel
        Participant

        Hi Robert,

        Yes, I did become NED while on the trial. I had active tumors at the start of the trial. I predict  that you too will become NED on your next set of scans.

        What kind of side effects do you have? I lost my thyroid function plus joint/muscle pain and rash.

        We have about 20 patients on this trial. Only a few are not responding. How many patients are in your trial???Are any of them not responding???

        There are no more openings at our site for this trial??? Any seats at  UCSF? My friend is trying to get into this trial.

        Best wishes to you.

        Marybelle

        • September 2, 2012 at 8:24 pm
        killmel
        Participant

        Hi Robert,

        Yes, I did become NED while on the trial. I had active tumors at the start of the trial. I predict  that you too will become NED on your next set of scans.

        What kind of side effects do you have? I lost my thyroid function plus joint/muscle pain and rash.

        We have about 20 patients on this trial. Only a few are not responding. How many patients are in your trial???Are any of them not responding???

        There are no more openings at our site for this trial??? Any seats at  UCSF? My friend is trying to get into this trial.

        Best wishes to you.

        Marybelle

      • September 2, 2012 at 2:47 am
      rbruce
      Participant

      Marybelle, first of all, I have to ask, how did you become NED? Is it from the trial or did you havevsurgical resection?  I too am on the Merck Anti-Pd1 trial (see my earlier post).  i get the full head to toe pet/ct every 12 weeks. Haven't had a brain MRI since the start of my trial 24 weeks ago.  Robert 

      • September 2, 2012 at 2:47 am
      rbruce
      Participant

      Marybelle, first of all, I have to ask, how did you become NED? Is it from the trial or did you havevsurgical resection?  I too am on the Merck Anti-Pd1 trial (see my earlier post).  i get the full head to toe pet/ct every 12 weeks. Haven't had a brain MRI since the start of my trial 24 weeks ago.  Robert 

      • September 2, 2012 at 3:48 am
      LynnLuc
      Participant

      I am on BMS's Anti PD 1 @ Moffitt  and have been in the trial since Fall 2010.  Stage 4 and I have been NED for 2 years 5 months. I get a brain MRI every 3 months and a CT of Neck, chest, abdomen and pelvic every 3 months.

        • September 2, 2012 at 6:37 pm
        Gene_S
        Participant

        Lynn I have a question for you.  I don't understand how you have been on a trial for not quite 2 years (Fall 2010) but you have been NED for 2 years and 5 months.  Is this trial for NED patients?

        Judy (loving wife of Gene)

        • September 2, 2012 at 6:37 pm
        Gene_S
        Participant

        Lynn I have a question for you.  I don't understand how you have been on a trial for not quite 2 years (Fall 2010) but you have been NED for 2 years and 5 months.  Is this trial for NED patients?

        Judy (loving wife of Gene)

        • September 2, 2012 at 6:37 pm
        Gene_S
        Participant

        Lynn I have a question for you.  I don't understand how you have been on a trial for not quite 2 years (Fall 2010) but you have been NED for 2 years and 5 months.  Is this trial for NED patients?

        Judy (loving wife of Gene)

        • September 3, 2012 at 6:51 am
        LynnLuc
        Participant

        I had surgery March 26, 2010 and then the trial I was suppose to get into in Seattle needed to confrim some things and finally said I couldn't do the trial because they needed measureable disease and froze down my cloned cells for perhaps future use.. I  then went to the NIH and they told me to come back in a couple months..I found my trial at Moffitt and started in late Aug/Sept.

        • September 3, 2012 at 6:57 am
        LynnLuc
        Participant

        PS  they started my trial for resected    "

        Phase I Study of Anti-PD-1 Human Monoclonal Antibody MDX-1106 (BMS-936558) and Vaccine Therapy Comprising gp100:209-217(210M) Peptide, MART-1:26-35(27L) Peptide, gp100:280-288(288V) Peptide, NY-ESO-1 Peptide, and Montanide ISA 51 VG in Patients With Resected Stage IV Melanoma" http://cancer.gov/clinicaltrials/search/view?cdrid=682183&version=HealthProfessional&protocolsearchid=10185044#AlternateTitle_CDR0000682183

         and then brought out the sister trial for unresected…             

        Phase I Pilot Study of Peptide Vaccine Comprising gp100:209-217(210M), MART-1:26-35(27L), gp100:280-288(288V), and NY-ESO-1 Emulsified in Montanide ISA 51 VG and Anti-PD-1 Human Monoclonal Antibody MDX-1106 in Patients With Unresectable Stage III or IV Melanoma  http://cancer.gov/clinicaltrials/search/view?cdrid=682171&version=HealthProfessional&protocolsearchid=10185044#AlternateTitle_CDR0000682171

        • September 3, 2012 at 7:02 am
        LynnLuc
        Participant

        I went to Moffitt In Aug for assessments and work ups and had my first Anti PD 1 on Sept 28, 2010….this week is my 101st week in the trial!

        • September 3, 2012 at 1:04 pm
        Gene_S
        Participant

        Hello Lynn,

        Thank you for the information.  Glad it is working for you to keep you NED.

        Judy (loving wife of Gene)

        • September 3, 2012 at 1:04 pm
        Gene_S
        Participant

        Hello Lynn,

        Thank you for the information.  Glad it is working for you to keep you NED.

        Judy (loving wife of Gene)

        • September 3, 2012 at 1:04 pm
        Gene_S
        Participant

        Hello Lynn,

        Thank you for the information.  Glad it is working for you to keep you NED.

        Judy (loving wife of Gene)

        • September 3, 2012 at 7:02 am
        LynnLuc
        Participant

        I went to Moffitt In Aug for assessments and work ups and had my first Anti PD 1 on Sept 28, 2010….this week is my 101st week in the trial!

        • September 3, 2012 at 7:02 am
        LynnLuc
        Participant

        I went to Moffitt In Aug for assessments and work ups and had my first Anti PD 1 on Sept 28, 2010….this week is my 101st week in the trial!

        • September 3, 2012 at 6:57 am
        LynnLuc
        Participant

        PS  they started my trial for resected    "

        Phase I Study of Anti-PD-1 Human Monoclonal Antibody MDX-1106 (BMS-936558) and Vaccine Therapy Comprising gp100:209-217(210M) Peptide, MART-1:26-35(27L) Peptide, gp100:280-288(288V) Peptide, NY-ESO-1 Peptide, and Montanide ISA 51 VG in Patients With Resected Stage IV Melanoma" http://cancer.gov/clinicaltrials/search/view?cdrid=682183&version=HealthProfessional&protocolsearchid=10185044#AlternateTitle_CDR0000682183

         and then brought out the sister trial for unresected…             

        Phase I Pilot Study of Peptide Vaccine Comprising gp100:209-217(210M), MART-1:26-35(27L), gp100:280-288(288V), and NY-ESO-1 Emulsified in Montanide ISA 51 VG and Anti-PD-1 Human Monoclonal Antibody MDX-1106 in Patients With Unresectable Stage III or IV Melanoma  http://cancer.gov/clinicaltrials/search/view?cdrid=682171&version=HealthProfessional&protocolsearchid=10185044#AlternateTitle_CDR0000682171

        • September 3, 2012 at 6:57 am
        LynnLuc
        Participant

        PS  they started my trial for resected    "

        Phase I Study of Anti-PD-1 Human Monoclonal Antibody MDX-1106 (BMS-936558) and Vaccine Therapy Comprising gp100:209-217(210M) Peptide, MART-1:26-35(27L) Peptide, gp100:280-288(288V) Peptide, NY-ESO-1 Peptide, and Montanide ISA 51 VG in Patients With Resected Stage IV Melanoma" http://cancer.gov/clinicaltrials/search/view?cdrid=682183&version=HealthProfessional&protocolsearchid=10185044#AlternateTitle_CDR0000682183

         and then brought out the sister trial for unresected…             

        Phase I Pilot Study of Peptide Vaccine Comprising gp100:209-217(210M), MART-1:26-35(27L), gp100:280-288(288V), and NY-ESO-1 Emulsified in Montanide ISA 51 VG and Anti-PD-1 Human Monoclonal Antibody MDX-1106 in Patients With Unresectable Stage III or IV Melanoma  http://cancer.gov/clinicaltrials/search/view?cdrid=682171&version=HealthProfessional&protocolsearchid=10185044#AlternateTitle_CDR0000682171

        • September 3, 2012 at 6:51 am
        LynnLuc
        Participant

        I had surgery March 26, 2010 and then the trial I was suppose to get into in Seattle needed to confrim some things and finally said I couldn't do the trial because they needed measureable disease and froze down my cloned cells for perhaps future use.. I  then went to the NIH and they told me to come back in a couple months..I found my trial at Moffitt and started in late Aug/Sept.

        • September 3, 2012 at 6:51 am
        LynnLuc
        Participant

        I had surgery March 26, 2010 and then the trial I was suppose to get into in Seattle needed to confrim some things and finally said I couldn't do the trial because they needed measureable disease and froze down my cloned cells for perhaps future use.. I  then went to the NIH and they told me to come back in a couple months..I found my trial at Moffitt and started in late Aug/Sept.

      • September 2, 2012 at 3:48 am
      LynnLuc
      Participant

      I am on BMS's Anti PD 1 @ Moffitt  and have been in the trial since Fall 2010.  Stage 4 and I have been NED for 2 years 5 months. I get a brain MRI every 3 months and a CT of Neck, chest, abdomen and pelvic every 3 months.

      • September 2, 2012 at 3:48 am
      LynnLuc
      Participant

      I am on BMS's Anti PD 1 @ Moffitt  and have been in the trial since Fall 2010.  Stage 4 and I have been NED for 2 years 5 months. I get a brain MRI every 3 months and a CT of Neck, chest, abdomen and pelvic every 3 months.

      • September 3, 2012 at 11:14 pm
      Harry in Fair Oaks
      Participant

      I'm on the GSK BRAF/MEK trial.  I do all the scans you mention, but on an 8-week schedule (except thet head MRI is only every other time – i.e. on 16-week schedule).

      Best wishes,

      Harry

        • September 4, 2012 at 1:37 am
        rbruce
        Participant

        Harry, Are you in Fair Oaks, California?  If so, I go by you every week on my way to SF.  Robert

        • September 5, 2012 at 12:50 am
        Harry in Fair Oaks
        Participant

        Hi Robert,

        You have to stop by for a beer soon!  I'm right off Hazel, on the cliff overlooking 50 and Lake Natoma – so you're passing within a mile or so of me.

        And I'm also 58, also have 3 kids (they're 27 – triplets).  But I've been married much longer than you – 31 years as of tomorrow.

        Let's get together soon.

        Best wishes,

        Harry

        • September 5, 2012 at 12:50 am
        Harry in Fair Oaks
        Participant

        Hi Robert,

        You have to stop by for a beer soon!  I'm right off Hazel, on the cliff overlooking 50 and Lake Natoma – so you're passing within a mile or so of me.

        And I'm also 58, also have 3 kids (they're 27 – triplets).  But I've been married much longer than you – 31 years as of tomorrow.

        Let's get together soon.

        Best wishes,

        Harry

        • September 5, 2012 at 12:50 am
        Harry in Fair Oaks
        Participant

        Hi Robert,

        You have to stop by for a beer soon!  I'm right off Hazel, on the cliff overlooking 50 and Lake Natoma – so you're passing within a mile or so of me.

        And I'm also 58, also have 3 kids (they're 27 – triplets).  But I've been married much longer than you – 31 years as of tomorrow.

        Let's get together soon.

        Best wishes,

        Harry

        • September 4, 2012 at 1:37 am
        rbruce
        Participant

        Harry, Are you in Fair Oaks, California?  If so, I go by you every week on my way to SF.  Robert

        • September 4, 2012 at 1:37 am
        rbruce
        Participant

        Harry, Are you in Fair Oaks, California?  If so, I go by you every week on my way to SF.  Robert

      • September 3, 2012 at 11:14 pm
      Harry in Fair Oaks
      Participant

      I'm on the GSK BRAF/MEK trial.  I do all the scans you mention, but on an 8-week schedule (except thet head MRI is only every other time – i.e. on 16-week schedule).

      Best wishes,

      Harry

      • September 3, 2012 at 11:14 pm
      Harry in Fair Oaks
      Participant

      I'm on the GSK BRAF/MEK trial.  I do all the scans you mention, but on an 8-week schedule (except thet head MRI is only every other time – i.e. on 16-week schedule).

      Best wishes,

      Harry

Viewing 8 reply threads
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