Re: Cushing’s Disease in Dogs

Based on what you posted, Cushing's disease can be responsible for all you have described and isn't all that rare.  Your vet is taking a thorough approach.  The urine tests are an indicator, but the blood tests (challenging the adrenal glands with dexamethasone to suppress cortisol and seeing what happens….) is much more conclusive.

Most cases of Cushing's disease is due to a tumor in the pituitary gland and can be managed.  If it is in the adrenal gland then possibly cured via surgery to remove an adrenal mass.  The bloodwork will be suggestive as to where the mass is located.  An abdominal ultrasound can scan the adrenals and other organs within the body.

Cushing's disease can cause an increased risk of blood clots, panting due to changes in the lungs, weakened muscles (thus a pot belly), thin hair, torn ligaments, liver problems, a poor immune system, and diabetes.  If diabetes occurs concurrently, it is VERY difficult to control until the Cushing's is addressed.

Average life expectancy after a Cushing's diagnosis is less than 2 years.  It will require frequent and regular blood work to monitor response to treatment, and there is something like a 50% relapse rate within one year.  This is usually dealt with adjusting the meds and more bloodwork to make sure all is well.

Cushing's is a chronic disease that will require lots of owner compliance, and commitment to treatment.  Unfortunately, very few owners are willing to do so because of the high maintenace required, especially if they have diabetes on top of everything else.  It is doable though….

Wishing you the best of luck, sounds like you found an astute DVM.

Kim K (also a DVM)