› Forums › General Melanoma Community › NKTR-214 + Nivo for stage 4 patients gets FDA Breakthrough Therapy Designation
- This topic has 6 replies, 3 voices, and was last updated 6 years, 5 months ago by
jbronicki.
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- August 2, 2019 at 12:56 pm
Well this was a surprise to see NKTR-214 + nivo get a special breakthrough therapy designation with FDA. Many of us stage 4 folk have been following the pipeline of new drugs especially in the melanoma resistant area and for the last two years this combination has been getting a lot of press but mainly for lack of trial information being provided at oncology meetings like ASCO. I will give a couple of links that cover the breaking news as well two video’s that cover the topic from how leading oncologist see the development of this new combination. https://www.onclive.com/web-exclusives/fda-grants-bempegaldesleukin-plus-nivolumab-breakthrough-designation-in-melanoma https://news.bms.com/press-release/partnering-news/nektar-therapeutics-and-bristol-myers-squibb-announce-us-fda-breakthro
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- August 2, 2019 at 12:59 pm
Here are the two video’s, first from Dr. Weber at ASCO 2018 at the 1:17 min mark and second one from ASCO 2019 featuring Dr. Jason Luke talking about NkTR-214. https://www.onclive.com/inside-oncology/asco-2018-news/asco-2018-dr-weber-highlights-exciting-abstracts-in-melanoma-
- August 2, 2019 at 1:18 pm
Sorry, I forgot Dr. Luke!!! https://www.youtube.com/watch?v=Qc1D2nKcbJg
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- August 2, 2019 at 1:57 pm
This is fascinating Ed, especially the “Antifreeze” component actually elongating half-life of IL-2, etcOn a side note, it wasn’t until just recently I’ve started watching the video links (i’ve been used to reading the articles). I have to say, these onclive videos are so FUN (i know that sounds weird) to watch. What would take me days of reading and rereading to even understand, is clearly articulated by these doctors in a different format that is easily ingested. I think I have a much better handle on these treatments from watching these videos. Does Dr. Weber or any of these doctors ever sleep! They do so much, as well as you. THANK YOU for sharing this, the information in this form is so digestable!
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- August 2, 2019 at 2:24 pm
Now, I don’t want to cause you any acid reflux disease but there is more from an Oncologist at MD Anderson, in way more detail talking about the Pivot trial of NKTR-214+ nivo, but it comes with a warning that Dr. Diab is hard to follow at times but the level of detail is excellent!!! https://www.youtube.com/watch?time_continue=3&v=kvyPL5W9ZTA https://www.youtube.com/watch?time_continue=14&v=FxPoXn8xc7g
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- August 2, 2019 at 5:13 pm
WOW! That’s great news, Ed! Thanks for sharing! Here’s my take from ASCO 2019 (it’s the first one I reviewed in this link) as well as some perspective on the studies (from 2013 and 2018) leading up to the present – for those of you who are interested: https://chaoticallypreciselifeloveandmelanoma.blogspot.com/2019/06/new-stuff-treatment-options-and-current.htmlSlowly we turn, but turn we do!! c
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- August 3, 2019 at 12:04 am
Don’t worry Ed, I already have GERD! Dr. Diab though did take a few run throughs. Celeste, just watched videos from Dr. Sondak from Moffitt on intralesionals. Pretty fascinating about how they are trying use the intralesionals not only to treat the injected tumor but also stimulating an overall immune response. I’ve gone down the rabbit hole of watching these videos, have to stop and get dinner now.
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