Update on Trial Progress
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Update on Trial Progress

› Forums › General Melanoma Community › Update on Trial Progress

  • Post
    • July 28, 2016 at 10:12 pm
    JoshF
    Participant

    Hi Everyone-

    I received a call today from the Sr Clinical Leader at MD Anderson. Just to bring everyone up to speed I'm doing the Phase2 trial of Adoptive Cell Therapy with low dose IL-2 and IPI. They took the CD8+ cells from my blood about a month ago, collected Mart 1+ cells and then let them grow. She said everything looked great and earliest infusion date of September 1st. I'm nervous, excited…hopeful. I know there's not a lot of people out there who haven't done this so it makes me scared….but is there any guarantee in anything we do? I had complete response on ipi and went for a while before recurring in a big way after starting PD-1. Currently, I've had 2 doses of ipi and 3 days of radiation with 7 to go. My 3rd infusion of ipi is scheduled for Aug 12th which would make me start trial a bit later to meet washout. On top of all that I had a 4mm punch biopsy yesterday for a tiny bump on side of scalp. Love the anxiety waiting to see what that is…as derm told me, clinically I wouldn;t be concerned but it's you so… he was going to leave it…I asked him to take it so I can know. Now I have decisions…go with early date or wait for another dose of ipi….any thoughts? I know this seems like a no brainer but with stuff like this I start to lose logical thinking…indecision…one of biggest problems I've had to deal with in my life. Hope everyone is well…

    Josh

Viewing 14 reply threads
  • Replies
      • July 28, 2016 at 11:53 pm
      Polymath
      Participant

      Hey Josh,

      Thanks for the update.  I love that you are doing ipi with radiation.  Its a good combo and with past response to ipi it could be putting the hurt on the bad guys.  With ACT following so closely, you may never know what treatment actually worked but we hope that it all works for you.  I would do the additional ipi dose given the above statements.  Best to you in the battle.

      Gary

      • July 28, 2016 at 11:53 pm
      Polymath
      Participant

      Hey Josh,

      Thanks for the update.  I love that you are doing ipi with radiation.  Its a good combo and with past response to ipi it could be putting the hurt on the bad guys.  With ACT following so closely, you may never know what treatment actually worked but we hope that it all works for you.  I would do the additional ipi dose given the above statements.  Best to you in the battle.

      Gary

      • July 28, 2016 at 11:53 pm
      Polymath
      Participant

      Hey Josh,

      Thanks for the update.  I love that you are doing ipi with radiation.  Its a good combo and with past response to ipi it could be putting the hurt on the bad guys.  With ACT following so closely, you may never know what treatment actually worked but we hope that it all works for you.  I would do the additional ipi dose given the above statements.  Best to you in the battle.

      Gary

      • July 29, 2016 at 1:10 am
      Bubbles
      Participant

      Hey Joshie!

      Your trial is going to give you ipi with the t-cells, right? If my memory serves and that is the case,  I reckon I'd move onto the trial asap! That way you get it all. Just my thinking. Hang in there. Sorry about one more spot! Sucky spot! Hopefully nothing….but you are about to do it in either way! Love, c

        • July 29, 2016 at 2:38 am
        JoshF
        Participant

        Yes!!! TCell, LD IL2 and ipi…I'm ready to get on with it!! And yes hopefully nothing on that little bump! For once I'd like a bump to be benign!! Thanks Celeste for everything!!

        love, 

        Joshie

        • July 29, 2016 at 2:38 am
        JoshF
        Participant

        Yes!!! TCell, LD IL2 and ipi…I'm ready to get on with it!! And yes hopefully nothing on that little bump! For once I'd like a bump to be benign!! Thanks Celeste for everything!!

        love, 

        Joshie

        • July 29, 2016 at 2:38 am
        JoshF
        Participant

        Yes!!! TCell, LD IL2 and ipi…I'm ready to get on with it!! And yes hopefully nothing on that little bump! For once I'd like a bump to be benign!! Thanks Celeste for everything!!

        love, 

        Joshie

      • July 29, 2016 at 1:10 am
      Bubbles
      Participant

      Hey Joshie!

      Your trial is going to give you ipi with the t-cells, right? If my memory serves and that is the case,  I reckon I'd move onto the trial asap! That way you get it all. Just my thinking. Hang in there. Sorry about one more spot! Sucky spot! Hopefully nothing….but you are about to do it in either way! Love, c

      • July 29, 2016 at 1:10 am
      Bubbles
      Participant

      Hey Joshie!

      Your trial is going to give you ipi with the t-cells, right? If my memory serves and that is the case,  I reckon I'd move onto the trial asap! That way you get it all. Just my thinking. Hang in there. Sorry about one more spot! Sucky spot! Hopefully nothing….but you are about to do it in either way! Love, c

      • August 1, 2016 at 1:01 pm
      ed williams
      Participant

      Hi Josh, I came across a great article in the New York Times in the health section on twitter by Denise Grady July 30 2016. I am going to give you the link, I hope it works but not sure since I found it on twitter under cancer Immunotheapy search. Hope things are good!!!!Ed   http://www.nytimes.com/2016/07/31/health/harnessing-the-immune-system-to-fight-cancer.html 

        • August 1, 2016 at 1:03 pm
        ed williams
        Participant

        Gosh, to get the article click on the picture of the guy sitting in what looks like a dentist chair below where it says page not found.

        • August 1, 2016 at 1:03 pm
        ed williams
        Participant

        Gosh, to get the article click on the picture of the guy sitting in what looks like a dentist chair below where it says page not found.

        • August 1, 2016 at 1:03 pm
        ed williams
        Participant

        Gosh, to get the article click on the picture of the guy sitting in what looks like a dentist chair below where it says page not found.

        • August 1, 2016 at 5:57 pm
        JoshF
        Participant

        Thanks Ed…good read. The antigen specific ACT is what I'm doing at MDA….I guess the theory behind it is that the CD 8+ cells they're growing are basically trained to recognize the mart 1 expression from tumors and go after it.

         Josh

        • August 1, 2016 at 5:57 pm
        JoshF
        Participant

        Thanks Ed…good read. The antigen specific ACT is what I'm doing at MDA….I guess the theory behind it is that the CD 8+ cells they're growing are basically trained to recognize the mart 1 expression from tumors and go after it.

         Josh

        • August 1, 2016 at 5:57 pm
        JoshF
        Participant

        Thanks Ed…good read. The antigen specific ACT is what I'm doing at MDA….I guess the theory behind it is that the CD 8+ cells they're growing are basically trained to recognize the mart 1 expression from tumors and go after it.

         Josh

      • August 1, 2016 at 1:01 pm
      ed williams
      Participant

      Hi Josh, I came across a great article in the New York Times in the health section on twitter by Denise Grady July 30 2016. I am going to give you the link, I hope it works but not sure since I found it on twitter under cancer Immunotheapy search. Hope things are good!!!!Ed   http://www.nytimes.com/2016/07/31/health/harnessing-the-immune-system-to-fight-cancer.html 

      • August 1, 2016 at 1:01 pm
      ed williams
      Participant

      Hi Josh, I came across a great article in the New York Times in the health section on twitter by Denise Grady July 30 2016. I am going to give you the link, I hope it works but not sure since I found it on twitter under cancer Immunotheapy search. Hope things are good!!!!Ed   http://www.nytimes.com/2016/07/31/health/harnessing-the-immune-system-to-fight-cancer.html 

      • August 2, 2016 at 3:54 pm
      BrianP
      Participant

      Josh,

      I haven't posted as much lately but I read all of your threads.  I'm glad to hear things are going well and quickly.  Wanted to ask you for the clinical trial designator for your trial.  Do you know if they are doing that trial at any other locations?

      Thanks,

      Brian

      • August 2, 2016 at 3:54 pm
      BrianP
      Participant

      Josh,

      I haven't posted as much lately but I read all of your threads.  I'm glad to hear things are going well and quickly.  Wanted to ask you for the clinical trial designator for your trial.  Do you know if they are doing that trial at any other locations?

      Thanks,

      Brian

      • August 2, 2016 at 3:54 pm
      BrianP
      Participant

      Josh,

      I haven't posted as much lately but I read all of your threads.  I'm glad to hear things are going well and quickly.  Wanted to ask you for the clinical trial designator for your trial.  Do you know if they are doing that trial at any other locations?

      Thanks,

      Brian

        • August 3, 2016 at 9:02 pm
        karimg
        Participant

        You can still find similar treatments in other trials close to where you live. Have you checked your CT options ?

        • August 3, 2016 at 9:02 pm
        karimg
        Participant

        You can still find similar treatments in other trials close to where you live. Have you checked your CT options ?

        • August 3, 2016 at 9:02 pm
        karimg
        Participant

        You can still find similar treatments in other trials close to where you live. Have you checked your CT options ?

      • August 2, 2016 at 4:23 pm
      BrianP
      Participant

      Think I found it Josh.  NCT02027935.

      Looks like only at MDA.

      • August 2, 2016 at 4:23 pm
      BrianP
      Participant

      Think I found it Josh.  NCT02027935.

      Looks like only at MDA.

      • August 2, 2016 at 4:23 pm
      BrianP
      Participant

      Think I found it Josh.  NCT02027935.

      Looks like only at MDA.

        • August 2, 2016 at 6:49 pm
        JoshF
        Participant

        Sorry yes only at MDA but I thought they said Seatlle (Hutchinson)… anyway I know Dr. Yee came from Seattle. Looks like a Sept 8th infusion date as lonng as screening the week before goes good. After talking to them yesterday the anxiety has really kicked in.

        • August 2, 2016 at 6:49 pm
        JoshF
        Participant

        Sorry yes only at MDA but I thought they said Seatlle (Hutchinson)… anyway I know Dr. Yee came from Seattle. Looks like a Sept 8th infusion date as lonng as screening the week before goes good. After talking to them yesterday the anxiety has really kicked in.

        • August 2, 2016 at 6:49 pm
        JoshF
        Participant

        Sorry yes only at MDA but I thought they said Seatlle (Hutchinson)… anyway I know Dr. Yee came from Seattle. Looks like a Sept 8th infusion date as lonng as screening the week before goes good. After talking to them yesterday the anxiety has really kicked in.

        • August 3, 2016 at 2:01 am
        Bubbles
        Participant

        Yee hah, Joshie! 8/8/16! For folks into numerology that's gotta be good! It sure sounds good to me! Hang in there! Love,c

        • August 3, 2016 at 2:01 am
        Bubbles
        Participant

        Yee hah, Joshie! 8/8/16! For folks into numerology that's gotta be good! It sure sounds good to me! Hang in there! Love,c

        • August 3, 2016 at 2:01 am
        Bubbles
        Participant

        Yee hah, Joshie! 8/8/16! For folks into numerology that's gotta be good! It sure sounds good to me! Hang in there! Love,c

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