??? for Bubbles
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??? for Bubbles

› Forums › General Melanoma Community › ??? for Bubbles

  • Post
    • July 26, 2016 at 10:51 am
    Jewel
    Participant

    First of all I would like to echo the words of so many of us on this Forum. Thank you so much for

    all you do to help educate us about this disease and the choices that are out there to help combat it.

    Recently you posted about responces between the Ipi and Pd1. My husband did the 4 doses of Ipi 3mg and

    finished in an 2015. My question is this, are the 3mg doses of Ipi showing the complete responses that the

    10 mg has? It seems to me that the majority if not all who are blessed with long term remission did the

    10mg. My husband has scans again in Aug and of course the anxiety is through the roof. Thanks again

    Bubbles.

     

    Jewel

Viewing 5 reply threads
  • Replies
      • July 26, 2016 at 2:47 pm
      Bubbles
      Participant

      Hi Jewel,

      The short answer is…YES! Patients given ipi can have durable responses at 3 or 10mg/kg doses. We do have more extended data collected on the 10mg/kg option because that was how it was given initially so the time line we can follow is longer. You have to look back a bit to find hard data on ipi because with the advent of anti-PD1 and immunotherapy combo's, ipi is 'old news'. But here, the researchers note specifically that dosing was not a significant varible when it comes to durable responses:  http://chaoticallypreciselifeloveandmelanoma.blogspot.ca/2013/11/melanoma-patientsalive-and-kicking-10.html

      Here is a more recent post with a great deal of data on patients given ipi:  http://chaoticallypreciselifeloveandmelanoma.blogspot.ca/2015/03/ipi-for-melanomathe-data-keeps-pouring.html

      The sad part about ipi is the low response rate (10-15% vs 40% for anti-PD1, not to mention various combo's) and increased rate of side effects generally. However, durable responses are certainly attained at both the 3 and 10 mg dosing regimen.

      Thanks for your kind words. Good luck in August! Celeste

        • July 27, 2016 at 2:08 am
        Jewel
        Participant
        Thank you Celeste!
        • July 27, 2016 at 2:08 am
        Jewel
        Participant
        Thank you Celeste!
        • July 27, 2016 at 2:08 am
        Jewel
        Participant
        Thank you Celeste!
      • July 26, 2016 at 2:47 pm
      Bubbles
      Participant

      Hi Jewel,

      The short answer is…YES! Patients given ipi can have durable responses at 3 or 10mg/kg doses. We do have more extended data collected on the 10mg/kg option because that was how it was given initially so the time line we can follow is longer. You have to look back a bit to find hard data on ipi because with the advent of anti-PD1 and immunotherapy combo's, ipi is 'old news'. But here, the researchers note specifically that dosing was not a significant varible when it comes to durable responses:  http://chaoticallypreciselifeloveandmelanoma.blogspot.ca/2013/11/melanoma-patientsalive-and-kicking-10.html

      Here is a more recent post with a great deal of data on patients given ipi:  http://chaoticallypreciselifeloveandmelanoma.blogspot.ca/2015/03/ipi-for-melanomathe-data-keeps-pouring.html

      The sad part about ipi is the low response rate (10-15% vs 40% for anti-PD1, not to mention various combo's) and increased rate of side effects generally. However, durable responses are certainly attained at both the 3 and 10 mg dosing regimen.

      Thanks for your kind words. Good luck in August! Celeste

      • July 26, 2016 at 2:47 pm
      Bubbles
      Participant

      Hi Jewel,

      The short answer is…YES! Patients given ipi can have durable responses at 3 or 10mg/kg doses. We do have more extended data collected on the 10mg/kg option because that was how it was given initially so the time line we can follow is longer. You have to look back a bit to find hard data on ipi because with the advent of anti-PD1 and immunotherapy combo's, ipi is 'old news'. But here, the researchers note specifically that dosing was not a significant varible when it comes to durable responses:  http://chaoticallypreciselifeloveandmelanoma.blogspot.ca/2013/11/melanoma-patientsalive-and-kicking-10.html

      Here is a more recent post with a great deal of data on patients given ipi:  http://chaoticallypreciselifeloveandmelanoma.blogspot.ca/2015/03/ipi-for-melanomathe-data-keeps-pouring.html

      The sad part about ipi is the low response rate (10-15% vs 40% for anti-PD1, not to mention various combo's) and increased rate of side effects generally. However, durable responses are certainly attained at both the 3 and 10 mg dosing regimen.

      Thanks for your kind words. Good luck in August! Celeste

      • July 26, 2016 at 3:34 pm
      ed williams
      Participant

      Hi Jewel, just to add to what you have been given is an article from ASCO with the same data that you will find on Celeste blog. Also if you look up Dr. James Allison who now works at M.D. Anderson and listen to any of his presentation about Ipi you will here him talk about patients who reach 3 year on survival graphs tend to stay responding. Best wishes!!!!Ed http://jco.ascopubs.org/content/early/2015/02/03/JCO.2014.56.2736.short

        • July 27, 2016 at 2:09 am
        Jewel
        Participant
        Thanks Ed!
        • July 27, 2016 at 2:09 am
        Jewel
        Participant
        Thanks Ed!
        • July 27, 2016 at 2:09 am
        Jewel
        Participant
        Thanks Ed!
      • July 26, 2016 at 3:34 pm
      ed williams
      Participant

      Hi Jewel, just to add to what you have been given is an article from ASCO with the same data that you will find on Celeste blog. Also if you look up Dr. James Allison who now works at M.D. Anderson and listen to any of his presentation about Ipi you will here him talk about patients who reach 3 year on survival graphs tend to stay responding. Best wishes!!!!Ed http://jco.ascopubs.org/content/early/2015/02/03/JCO.2014.56.2736.short

      • July 26, 2016 at 3:34 pm
      ed williams
      Participant

      Hi Jewel, just to add to what you have been given is an article from ASCO with the same data that you will find on Celeste blog. Also if you look up Dr. James Allison who now works at M.D. Anderson and listen to any of his presentation about Ipi you will here him talk about patients who reach 3 year on survival graphs tend to stay responding. Best wishes!!!!Ed http://jco.ascopubs.org/content/early/2015/02/03/JCO.2014.56.2736.short

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