Abemaciclib for melanoma with leptomeningeal metasatses
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Abemaciclib for melanoma with leptomeningeal metasatses

› Forums › General Melanoma Community › Abemaciclib for melanoma with leptomeningeal metasatses

  • Post
    • April 20, 2016 at 7:36 pm
    Maxapooh
    Participant

    Hi everyone, 

    My doc wants me to try a clinical trial with Abemaciclib ( LY2835219, Eli Lilly ) 

    Has anyone heard of it? Any information will be appreciated. 

Viewing 5 reply threads
  • Replies
      • April 21, 2016 at 12:55 am
      sister of patient
      Participant

      Hello Maria,

      I'm just a newcomer here and I'm not even the one who is ill in my family so I'm still just trying to learn and understand everything I can about this disease myself. In other words – I'm certainly no expert and not in any position to advise anyone about anything!!

      But I do want to say I'm so sorry you have this awful illness to begin with and I will be thinking special good thoughts for you! I believe if I was in your shoes I think I would start the trial. This ugly monster called melanoma is already complicated enough but it sounds like you have an extra complication. The drug appears to be associated primarily with breast cancer but who's to say what it may achieve results for.

      The breakthroughs these specialists and researchers are making, every day, to find "the key" are absolutely astounding, in my opinion.

      I truly wish you the best and will keep sending good thoughts "out there" for you.

      Barb 

       

       

      • April 21, 2016 at 12:55 am
      sister of patient
      Participant

      Hello Maria,

      I'm just a newcomer here and I'm not even the one who is ill in my family so I'm still just trying to learn and understand everything I can about this disease myself. In other words – I'm certainly no expert and not in any position to advise anyone about anything!!

      But I do want to say I'm so sorry you have this awful illness to begin with and I will be thinking special good thoughts for you! I believe if I was in your shoes I think I would start the trial. This ugly monster called melanoma is already complicated enough but it sounds like you have an extra complication. The drug appears to be associated primarily with breast cancer but who's to say what it may achieve results for.

      The breakthroughs these specialists and researchers are making, every day, to find "the key" are absolutely astounding, in my opinion.

      I truly wish you the best and will keep sending good thoughts "out there" for you.

      Barb 

       

       

        • April 21, 2016 at 6:29 am
        Maxapooh
        Participant

        Thank you, Barb:)

        • April 21, 2016 at 6:29 am
        Maxapooh
        Participant

        Thank you, Barb:)

        • April 21, 2016 at 6:29 am
        Maxapooh
        Participant

        Thank you, Barb:)

      • April 21, 2016 at 12:55 am
      sister of patient
      Participant

      Hello Maria,

      I'm just a newcomer here and I'm not even the one who is ill in my family so I'm still just trying to learn and understand everything I can about this disease myself. In other words – I'm certainly no expert and not in any position to advise anyone about anything!!

      But I do want to say I'm so sorry you have this awful illness to begin with and I will be thinking special good thoughts for you! I believe if I was in your shoes I think I would start the trial. This ugly monster called melanoma is already complicated enough but it sounds like you have an extra complication. The drug appears to be associated primarily with breast cancer but who's to say what it may achieve results for.

      The breakthroughs these specialists and researchers are making, every day, to find "the key" are absolutely astounding, in my opinion.

      I truly wish you the best and will keep sending good thoughts "out there" for you.

      Barb 

       

       

      • April 21, 2016 at 3:23 pm
      ed williams
      Participant

      Hi Maxapooh, from what I read on line they are trying to use it in combination with targeted Braf and Mek drugs to help in trying to stop resistance to the drugs. Abemaciclib was given break through status last year in breast cancer and from what I can see it targets the CDK4 pathway. I couldn't find any specific trials for Melanoma, maybe someone else might have the answer. If you go to " Onclive" web site and click on Melanoma and go back 4 pages in the list of titles you will find an article from Dr. Keith Flaherty of Massachusetts General in Boston, where he talks about Braf/Mek inhibiton and the drug combination that are working. He might be a good person to try and contact!!! Best wishes!!!Ed

      • April 21, 2016 at 3:23 pm
      ed williams
      Participant

      Hi Maxapooh, from what I read on line they are trying to use it in combination with targeted Braf and Mek drugs to help in trying to stop resistance to the drugs. Abemaciclib was given break through status last year in breast cancer and from what I can see it targets the CDK4 pathway. I couldn't find any specific trials for Melanoma, maybe someone else might have the answer. If you go to " Onclive" web site and click on Melanoma and go back 4 pages in the list of titles you will find an article from Dr. Keith Flaherty of Massachusetts General in Boston, where he talks about Braf/Mek inhibiton and the drug combination that are working. He might be a good person to try and contact!!! Best wishes!!!Ed

        • April 23, 2016 at 3:01 pm
        Maxapooh
        Participant

        Hi Ed! Thank you for the information. I' ve been on Braf/mek since last August, they added Keytruda this March. My last ct scan showed spread to lungs, spleen and groin. As for now I have leptomeningeal metasatses , metasatses in liver, ovaries, lungs, spleen, bones and lymph node in groin. My hip bone has been destroyed by radiation. I have nothing to lose. I'm gonna go for this trial and if it doesn't  work for me, I have an option to try Temozolomide.

         

        • April 23, 2016 at 3:01 pm
        Maxapooh
        Participant

        Hi Ed! Thank you for the information. I' ve been on Braf/mek since last August, they added Keytruda this March. My last ct scan showed spread to lungs, spleen and groin. As for now I have leptomeningeal metasatses , metasatses in liver, ovaries, lungs, spleen, bones and lymph node in groin. My hip bone has been destroyed by radiation. I have nothing to lose. I'm gonna go for this trial and if it doesn't  work for me, I have an option to try Temozolomide.

         

        • April 23, 2016 at 3:01 pm
        Maxapooh
        Participant

        Hi Ed! Thank you for the information. I' ve been on Braf/mek since last August, they added Keytruda this March. My last ct scan showed spread to lungs, spleen and groin. As for now I have leptomeningeal metasatses , metasatses in liver, ovaries, lungs, spleen, bones and lymph node in groin. My hip bone has been destroyed by radiation. I have nothing to lose. I'm gonna go for this trial and if it doesn't  work for me, I have an option to try Temozolomide.

         

      • April 21, 2016 at 3:23 pm
      ed williams
      Participant

      Hi Maxapooh, from what I read on line they are trying to use it in combination with targeted Braf and Mek drugs to help in trying to stop resistance to the drugs. Abemaciclib was given break through status last year in breast cancer and from what I can see it targets the CDK4 pathway. I couldn't find any specific trials for Melanoma, maybe someone else might have the answer. If you go to " Onclive" web site and click on Melanoma and go back 4 pages in the list of titles you will find an article from Dr. Keith Flaherty of Massachusetts General in Boston, where he talks about Braf/Mek inhibiton and the drug combination that are working. He might be a good person to try and contact!!! Best wishes!!!Ed

Viewing 5 reply threads
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