Nivolumab and Ipilimumab combo
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Nivolumab and Ipilimumab combo

› Forums › General Melanoma Community › Nivolumab and Ipilimumab combo

  • Post
    • March 24, 2015 at 2:09 am
    Kathy himes
    Participant

    Hi. My wife has started treatment and after one cycle her liver enzymes have shot up. Has anyone gone through this?. Thanks, Doug

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  • Replies
      • March 24, 2015 at 3:07 am
      dvd
      Participant

      I was on the BMS ipi plus nivo or placebo trial last year. Although a blinded trial, all indications are that I received nivo rather than the placebo (ipi 3mg/kg + nivo 1mg/kg). After 4 doses over 3 months my hepatic enzymes spiked to about 8X normal, although I was asymptomatic. I was teminated from the trial (I was NED by then and have remained so) and put on a tapering dose of steroids which brought my liver function tests back to normal over the next 2 months.

      That combination, although remarkably effective, does have a majority of patients getting significant side effects. I have heard of patients having their side effects being treated with steroids but, in some cases, continuing with infusions.

      Best of luck – hope things work out for continued immunotherapy treatments.

      DVD

        • March 24, 2015 at 5:15 pm
        Kathy himes
        Participant

        Thanks so much for your inputs. Good luck. 

        • March 24, 2015 at 5:15 pm
        Kathy himes
        Participant

        Thanks so much for your inputs. Good luck. 

        • March 24, 2015 at 5:15 pm
        Kathy himes
        Participant

        Thanks so much for your inputs. Good luck. 

      • March 24, 2015 at 3:07 am
      dvd
      Participant

      I was on the BMS ipi plus nivo or placebo trial last year. Although a blinded trial, all indications are that I received nivo rather than the placebo (ipi 3mg/kg + nivo 1mg/kg). After 4 doses over 3 months my hepatic enzymes spiked to about 8X normal, although I was asymptomatic. I was teminated from the trial (I was NED by then and have remained so) and put on a tapering dose of steroids which brought my liver function tests back to normal over the next 2 months.

      That combination, although remarkably effective, does have a majority of patients getting significant side effects. I have heard of patients having their side effects being treated with steroids but, in some cases, continuing with infusions.

      Best of luck – hope things work out for continued immunotherapy treatments.

      DVD

      • March 24, 2015 at 3:07 am
      dvd
      Participant

      I was on the BMS ipi plus nivo or placebo trial last year. Although a blinded trial, all indications are that I received nivo rather than the placebo (ipi 3mg/kg + nivo 1mg/kg). After 4 doses over 3 months my hepatic enzymes spiked to about 8X normal, although I was asymptomatic. I was teminated from the trial (I was NED by then and have remained so) and put on a tapering dose of steroids which brought my liver function tests back to normal over the next 2 months.

      That combination, although remarkably effective, does have a majority of patients getting significant side effects. I have heard of patients having their side effects being treated with steroids but, in some cases, continuing with infusions.

      Best of luck – hope things work out for continued immunotherapy treatments.

      DVD

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