m355

this is my 3rd melanoma. given it is my 3rd, the derm, pathologist and oncologist said it is something to consider.  and here is the most recent report:

Here is lab report:

A) Skin, right upper back, punch biopsy: Severely
atypical compound melanocytic proliferation, see
Comment.

COMMENT:
This is a worrisome lesion, with epidermal atypia
(pagetoid extension, confluent growth) consistent with
melanoma in situ and a dermal component that also
demonstrates atypia with areas of morphologically
similar cells to the epidermal component, but also some
 reassuring features (dispersion with increasing dermal
 depth, absence of mitoses). These findings engender a
differential diagnosis that could reasonably include
melanoma in situ evolving within a dysplastic nevus or
a superfically invasive melanoma. Given this
differential, it would be reasonable to treat this
lesion as if it represents a malignant melanoma with
the following prognostic factors: Breslow depth 0.32mm,
 Clark's level II, 0 mitoses/mm2, no ulceration.
 

MICROSCOPIC DESCRIPTION:
A) Sections show a punch biopsy with a compound
melanocytic proliferation. The junctional component
shows crowding, with fusion between adjacent rete and
horizontal nests. Areas of upward extension of single
melanocytes and nests are seen, and highlighted by
Melan-A. Intraepidermal melanocytes show cytologic
atypia, with nuclear enlargement and abundant
cytoplasm. A patchy lymphohistiocytic inflammatory
infiltrate is present. The lesion is free of the punch
biopsy margin. Additional step sections are examined.
 

this is my 3rd melanoma. given it is my 3rd, the derm, pathologist and oncologist said it is something to consider.  and here is the most recent report:

Here is lab report:

A) Skin, right upper back, punch biopsy: Severely
atypical compound melanocytic proliferation, see
Comment.

COMMENT:
This is a worrisome lesion, with epidermal atypia
(pagetoid extension, confluent growth) consistent with
melanoma in situ and a dermal component that also
demonstrates atypia with areas of morphologically
similar cells to the epidermal component, but also some
 reassuring features (dispersion with increasing dermal
 depth, absence of mitoses). These findings engender a
differential diagnosis that could reasonably include
melanoma in situ evolving within a dysplastic nevus or
a superfically invasive melanoma. Given this
differential, it would be reasonable to treat this
lesion as if it represents a malignant melanoma with
the following prognostic factors: Breslow depth 0.32mm,
 Clark's level II, 0 mitoses/mm2, no ulceration.
 

MICROSCOPIC DESCRIPTION:
A) Sections show a punch biopsy with a compound
melanocytic proliferation. The junctional component
shows crowding, with fusion between adjacent rete and
horizontal nests. Areas of upward extension of single
melanocytes and nests are seen, and highlighted by
Melan-A. Intraepidermal melanocytes show cytologic
atypia, with nuclear enlargement and abundant
cytoplasm. A patchy lymphohistiocytic inflammatory
infiltrate is present. The lesion is free of the punch
biopsy margin. Additional step sections are examined.
 

this is my 3rd melanoma. given it is my 3rd, the derm, pathologist and oncologist said it is something to consider.  and here is the most recent report:

Here is lab report:

A) Skin, right upper back, punch biopsy: Severely
atypical compound melanocytic proliferation, see
Comment.

COMMENT:
This is a worrisome lesion, with epidermal atypia
(pagetoid extension, confluent growth) consistent with
melanoma in situ and a dermal component that also
demonstrates atypia with areas of morphologically
similar cells to the epidermal component, but also some
 reassuring features (dispersion with increasing dermal
 depth, absence of mitoses). These findings engender a
differential diagnosis that could reasonably include
melanoma in situ evolving within a dysplastic nevus or
a superfically invasive melanoma. Given this
differential, it would be reasonable to treat this
lesion as if it represents a malignant melanoma with
the following prognostic factors: Breslow depth 0.32mm,
 Clark's level II, 0 mitoses/mm2, no ulceration.
 

MICROSCOPIC DESCRIPTION:
A) Sections show a punch biopsy with a compound
melanocytic proliferation. The junctional component
shows crowding, with fusion between adjacent rete and
horizontal nests. Areas of upward extension of single
melanocytes and nests are seen, and highlighted by
Melan-A. Intraepidermal melanocytes show cytologic
atypia, with nuclear enlargement and abundant
cytoplasm. A patchy lymphohistiocytic inflammatory
infiltrate is present. The lesion is free of the punch
biopsy margin. Additional step sections are examined.
 

I do make alot of atypical moles that is for sure.  But nothing crazy, crazy are the normal ones that go rogue. My thoughts exactly if there was to ever be a treatment advantage.

I do make alot of atypical moles that is for sure.  But nothing crazy, crazy are the normal ones that go rogue. My thoughts exactly if there was to ever be a treatment advantage.

I do make alot of atypical moles that is for sure.  But nothing crazy, crazy are the normal ones that go rogue. My thoughts exactly if there was to ever be a treatment advantage.