Hi Jackie, thanks for your reply. We are awaiting BRAF pathology, but were advised to start the Opdivo/Yervoy right away, rather than wait for the results. We should know by the end of this week. We just got insurance approval for the immunotherapy and are scheduled to start this Thursday. Mom is not doing well. Still not eating and has started to get some edema in her feet. Pain is somewhat managed, but still breaks through at a level of 10/10 periodically, usually worse in the morning. I’m sure we will learn about this at our education appointment on Wednesday, but do you know how long it typically takes to see any improvement in symptoms or disease burden with immunotherapy? I truly appreciate your response!