David McCaw
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David McCaw

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      • April 7, 2017 at 10:25 pm
      David McCaw
      Participant
      Lisa, what are the WBC and liver minimums for the Tils trial? Which trial at msk is your onc recommending, possibly this one, NCT02535078, IMCgp100-201, Phase 1b/2 Study of the Combination of IMCgp100 With Durvalumab and/or Tremelimumab in Cutaneous Melanoma; the prime is Alexander N. Shoushtari from Memorial Sloan Kettering Cancer Center.

      Also, Ed Williams provided me information on an interesting trial in Salt Lake city, where they are working to getting patients that did not respond to pd1 and have got more than 40% according to an Asco report.NCT02493361, 15852, Trial of pIL-12/MK-3475 in Metastatic Melanoma, contact Tamara, (801) 587-4767,tamara.willis@hci.utah.edu

      • April 7, 2017 at 12:49 pm
      David McCaw
      Participant

      I am sorry, you did not pass the assessment.  I will be going through a similar exercise in Canada,  starting on April 25.  Ipi/nivo  failed for me, although i did 4 combos and 2 monos.  I have been on MEK inhibitors cotellic for two weeks,  but no shrinkage yet. I have a rare braf mutation,  k601n.  I wish you well in your journey at MSK,  I might be down there or another location if the Tils trial does not pan out. Since all i am being offered later is tvec which probably won't help my liver or lungs.  Don't give up hope.  keep going.

      • March 27, 2017 at 1:25 am
      David McCaw
      Participant

      also if you need more support contact Annette Cyr of Melanoma Network Canada, acyr@melanomanetwork.ca

      • March 27, 2017 at 1:17 am
      David McCaw
      Participant

      Hi Janis, Ontario funds either ipi or keytruda but not both.  Follow up with your oncologist, they should know.  or get another oncologist.  

      • March 4, 2017 at 5:05 pm
      David McCaw
      Participant

      I have read that some patients have their cells stored at MD Anderson.   Below is the contact information for the lab

      Chantale Bernatchez, Ph.D.
      Director
      Phone: 713-563-8830
      Email: cbernatchez@mdanderson.org

      Location

      The TIL Lab is located in the Center for Cancer Immunology Research (CCIR) at the South Campus of MD Anderson Cancer Center (7455 Fannin, Houston, Texas). We have a cGMP-quality laboratory where clinical-grade TIL are expanded from fresh tumor samples.

      https://www.mdanderson.org/research/departments-labs-institutes/labs/til-laboratory/research.html

      • February 24, 2017 at 1:04 pm
      David McCaw
      Participant

      As Ed stated previously, it's a small world. I lived in Paul's hometown during the 70's (high school and college ). I still have family there and will be dropping in during March. I really enjoyed Paul's posts, an amazing man and will be sadly missed and as a stage 4 melanoma patient,  I must be as brave as Paul to keep living life to its fullest. My condolences to his family and friends.  Such an unfair end of  life. I was really rooting for Paul to get to the next trial. Hopefully others will continue to remember Paul, and not give up hope.  I am still reading Paul's posts, he was a real fighter / warrior and shared his thoughts openly.

      • February 8, 2017 at 7:46 pm
      David McCaw
      Participant

      Hi Anon,  here is an article written by Catherine Poole on the MIF board. Also, did you speak with Marcus Butler at Princess Margaret hospital or Pamela Ohashi.  I am also interested in the program 

      http://melanomainternational.org/2015/05/til-therapy-for-melanoma-magic-bullet-or/#.WJt0CE6vC2c

      • February 8, 2017 at 7:46 pm
      David McCaw
      Participant

      Hi Anon,  here is an article written by Catherine Poole on the MIF board. Also, did you speak with Marcus Butler at Princess Margaret hospital or Pamela Ohashi.  I am also interested in the program 

      http://melanomainternational.org/2015/05/til-therapy-for-melanoma-magic-bullet-or/#.WJt0CE6vC2c

      • February 8, 2017 at 7:46 pm
      David McCaw
      Participant

      Hi Anon,  here is an article written by Catherine Poole on the MIF board. Also, did you speak with Marcus Butler at Princess Margaret hospital or Pamela Ohashi.  I am also interested in the program 

      http://melanomainternational.org/2015/05/til-therapy-for-melanoma-magic-bullet-or/#.WJt0CE6vC2c

      • February 7, 2017 at 1:34 pm
      David McCaw
      Participant

      I have done 4 combos,.Only fatigue and rash. They did scans at zero and week 8, unfortunately I had progression to liver and lungs. ( ( previously stage 3c with intransits on left inner thigh, after clnd on 9/29)I am scheduled to have first maintenance nivo on week 12 in 10 days. They will do another CT scan at week 15, if progression,  I will take Braf inhibitors combi V. I am hoping that I am a late responder.  I wish everyone well in their treatments and to either be NED or become NED.  I am also interested in any late responders.

      • February 7, 2017 at 1:34 pm
      David McCaw
      Participant

      I have done 4 combos,.Only fatigue and rash. They did scans at zero and week 8, unfortunately I had progression to liver and lungs. ( ( previously stage 3c with intransits on left inner thigh, after clnd on 9/29)I am scheduled to have first maintenance nivo on week 12 in 10 days. They will do another CT scan at week 15, if progression,  I will take Braf inhibitors combi V. I am hoping that I am a late responder.  I wish everyone well in their treatments and to either be NED or become NED.  I am also interested in any late responders.

      • April 12, 2017 at 11:53 am
      David McCaw
      Participant

      Thanks for your input Caitlin.  I think for now I will contact NIH.  Take care

      • April 12, 2017 at 11:50 am
      David McCaw
      Participant

      Thanks for the advice Tom.  All the best to your good  health.

      • April 12, 2017 at 3:02 am
      David McCaw
      Participant

      Thanks Terrie, that good to know. I will reach out to them. Is there any particular person to contact for international patients,  if not i will call and ask.  I appreciate your help,  it good to have options 

      • March 18, 2017 at 7:33 pm
      David McCaw
      Participant

      Thanks Celeste, I did get a reply back from Dr. Flaherty around midnight ( no after hours ?) that gives me better direction , so keep to Mek inhibitors only and pray for major shrinkage ASAP to keep moving.

      "There are only anecdotes. I haven't heard of a single response to vemurafenib or dabrafenib in the setting of a K601 mutation. The laboratory data are fairly clear that melanoma cells that have these mutations are not sensitive to BRAF inhibitors, but are to MEK inhibitors."

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