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It’s over a month now since BMS issued a Press Release stating that their checkpoint inhibitor anti LAG/3 drug Relatlimab had been successful in Phase 2/3 trials in combination with Nivo. As a PD/1 failure, I am especially keen to digest the efficacy figures. Why the delay?
Hi Tim, first off that is pretty normal at this time of year for all the big pharma companies with trials that are being reported on. They tend to try and build up expectations for ASCO where they will have a lot of eyes on what is new and promising. Lag-3 is being looked at in more than one way including treatment naive patients and this report of trial by BMS is on treatment naive patients not progressors as I read there recent article (see below Onclive artilce on same report). Dr. Omid Hamid of the Angeles clinic gave a really nice presentation not that long ago about what is coming in the research area ( see second link below) and there are several to follow including Lag-3 in those that have progressed. In the video he gets into that topic around 4:30 min mark and at 5;30 he is talking about Lag-3. Some of the other one that I am waiting on and will probably be available for melanoma resistant tumors would be NKTR-214 Bempeg and Lifuecels TIL’s program which is at FDA at present. https://www.onclive.com/view/relatlimab-nivolumab-improves-pfs-in-previously-untreated-metastatic-or-unresectable-melanoma https://www.youtube.com/watch?v=_wAUkQdTt1g&list=PLOnM_erAQqIBj54P2wviZ3WxV_okkn58Y
Many thanks,Ed. I’m new to this forum (and melanoma) so I found your reply most interesting and informative. Take care and best wishes from England
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