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what next for ocular mets to liver and bone?
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what next for ocular mets to liver and bone?

› Forums › Ocular Melanoma Community › what next for ocular mets to liver and bone?

  • Post
    • May 11, 2012 at 6:25 pm
    margaretrogers57
    Participant

      Dear  Friends,

       

      My husband has had ipi and gm-csf in trial.  Showed progression although small in some mm sized tumors.  We went to y-90 next.  2 1/2 months after rt. and a month after left lobe treated, tumors were significantly bigger.  Also some bone mets appeared. Talking about Temoolomide or azd6244 trial @ vanderbilt or pd-1 drug @ moffitt.  Anyone out there that has done these?  Thanks, margaret

      Dear  Friends,

       

      My husband has had ipi and gm-csf in trial.  Showed progression although small in some mm sized tumors.  We went to y-90 next.  2 1/2 months after rt. and a month after left lobe treated, tumors were significantly bigger.  Also some bone mets appeared. Talking about Temoolomide or azd6244 trial @ vanderbilt or pd-1 drug @ moffitt.  Anyone out there that has done these?  Thanks, margaret

    Viewing 2 reply threads
    • Replies
        • June 19, 2012 at 4:54 pm
        paperdetective
        Participant

          Margaret,

          Have you investigated the HDAC inhibitors? It is a generation of drugs that already exists and is approved for other diseases and recently a lot of scientists (especially Dr J William Harbour in vitro and with mice)  have established that HDAC inhibitors slow and/or stop further systemic OM metastasis.

          A first trial of a HDAC inhibitor (Vorinostat) was just started in Philadelphia. I believe that, regardless of that trial, other oncologists may also prescribe an HDAC inhibitor in case of advanced OM mets (I know at least of one, Dr Takami Sato, who does and he may even indirectly involved in teh trial).

          See more info at

          http://www.mskcc.org/cancer-care/trial/12-027

          http://www.ocular-melanoma.com/docs/targeted_therapy_uveal_melanoma.pdf

          More trials of other HDAC inhibitors are due to start shortly. I know that Dr William Harbour in St Louis has funding to start one with Valproic Acid, another HDAC (he believs more in that one and has used it in his previous tests). So you may want to call him too to ask the status.

           

          Peter L in NH

          • June 19, 2012 at 4:54 pm
          paperdetective
          Participant

            Margaret,

            Have you investigated the HDAC inhibitors? It is a generation of drugs that already exists and is approved for other diseases and recently a lot of scientists (especially Dr J William Harbour in vitro and with mice)  have established that HDAC inhibitors slow and/or stop further systemic OM metastasis.

            A first trial of a HDAC inhibitor (Vorinostat) was just started in Philadelphia. I believe that, regardless of that trial, other oncologists may also prescribe an HDAC inhibitor in case of advanced OM mets (I know at least of one, Dr Takami Sato, who does and he may even indirectly involved in teh trial).

            See more info at

            http://www.mskcc.org/cancer-care/trial/12-027

            http://www.ocular-melanoma.com/docs/targeted_therapy_uveal_melanoma.pdf

            More trials of other HDAC inhibitors are due to start shortly. I know that Dr William Harbour in St Louis has funding to start one with Valproic Acid, another HDAC (he believs more in that one and has used it in his previous tests). So you may want to call him too to ask the status.

             

            Peter L in NH

            • June 19, 2012 at 4:54 pm
            paperdetective
            Participant

              Margaret,

              Have you investigated the HDAC inhibitors? It is a generation of drugs that already exists and is approved for other diseases and recently a lot of scientists (especially Dr J William Harbour in vitro and with mice)  have established that HDAC inhibitors slow and/or stop further systemic OM metastasis.

              A first trial of a HDAC inhibitor (Vorinostat) was just started in Philadelphia. I believe that, regardless of that trial, other oncologists may also prescribe an HDAC inhibitor in case of advanced OM mets (I know at least of one, Dr Takami Sato, who does and he may even indirectly involved in teh trial).

              See more info at

              http://www.mskcc.org/cancer-care/trial/12-027

              http://www.ocular-melanoma.com/docs/targeted_therapy_uveal_melanoma.pdf

              More trials of other HDAC inhibitors are due to start shortly. I know that Dr William Harbour in St Louis has funding to start one with Valproic Acid, another HDAC (he believs more in that one and has used it in his previous tests). So you may want to call him too to ask the status.

               

              Peter L in NH

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