› Forums › General Melanoma Community › what do all these things mean?
- This topic has 9 replies, 3 voices, and was last updated 12 years, 7 months ago by
Janner.
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- June 2, 2012 at 1:04 pm
Hi, we're new here – new to melanoma and just learning. My husband's case is atypical – no sign of melanoma on the skin, just a mass removed from under his scalp. The path report doesn't include depth or thickness – just says that a "primary dermal melanoma gross measurement 9.5mm" is possible. "Large nodule filling the dermis with central necrosis composed of mitotically active, S100 positive, focal CD68 positive epithelioid cells." Also, immunoperoxidase stains found positive for nerve growth factor receptor and SOX 10, negative for Melan A and HMB45.
Hi, we're new here – new to melanoma and just learning. My husband's case is atypical – no sign of melanoma on the skin, just a mass removed from under his scalp. The path report doesn't include depth or thickness – just says that a "primary dermal melanoma gross measurement 9.5mm" is possible. "Large nodule filling the dermis with central necrosis composed of mitotically active, S100 positive, focal CD68 positive epithelioid cells." Also, immunoperoxidase stains found positive for nerve growth factor receptor and SOX 10, negative for Melan A and HMB45.
Does anyone know what those things mean?
Thanks for whatever you can offer.
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- June 2, 2012 at 1:36 pm
I'm sorry you've had to join us. About 8% people that have melanoma do not have a primary mole. I'm sure that your husband has been now checked to see if there was a mole that was missed. In his case they cannot tell the thickness of the mole because their was not one to measure.
S100 is the stain that they test for melanoma.
Have they done a PET scan so they can make sure that the rest of the body is clear?
I hope someone else is able to help you with other terms. The weekend is often slow.
Linda
stage IV since 06 (presently 1 brain met)
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- June 2, 2012 at 2:17 pm
Linda, thanks for responding so quickly – I really wasn't expecting to hear from anyone quite so soon.
The PET scan was clean – no evidence of FDG uptake anywhere but around the original site. There, it is described as "tiny, mildly to moderately hypermetabolic (SUV max 3.8) focal FDG uptake superficially in the scalp." They will do a wider excision and sentinel node biopsy in two weeks.
Be well – and thanks again!
HB
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- June 2, 2012 at 2:17 pm
Linda, thanks for responding so quickly – I really wasn't expecting to hear from anyone quite so soon.
The PET scan was clean – no evidence of FDG uptake anywhere but around the original site. There, it is described as "tiny, mildly to moderately hypermetabolic (SUV max 3.8) focal FDG uptake superficially in the scalp." They will do a wider excision and sentinel node biopsy in two weeks.
Be well – and thanks again!
HB
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- June 2, 2012 at 2:17 pm
Linda, thanks for responding so quickly – I really wasn't expecting to hear from anyone quite so soon.
The PET scan was clean – no evidence of FDG uptake anywhere but around the original site. There, it is described as "tiny, mildly to moderately hypermetabolic (SUV max 3.8) focal FDG uptake superficially in the scalp." They will do a wider excision and sentinel node biopsy in two weeks.
Be well – and thanks again!
HB
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- June 2, 2012 at 1:36 pm
I'm sorry you've had to join us. About 8% people that have melanoma do not have a primary mole. I'm sure that your husband has been now checked to see if there was a mole that was missed. In his case they cannot tell the thickness of the mole because their was not one to measure.
S100 is the stain that they test for melanoma.
Have they done a PET scan so they can make sure that the rest of the body is clear?
I hope someone else is able to help you with other terms. The weekend is often slow.
Linda
stage IV since 06 (presently 1 brain met)
-
- June 2, 2012 at 1:36 pm
I'm sorry you've had to join us. About 8% people that have melanoma do not have a primary mole. I'm sure that your husband has been now checked to see if there was a mole that was missed. In his case they cannot tell the thickness of the mole because their was not one to measure.
S100 is the stain that they test for melanoma.
Have they done a PET scan so they can make sure that the rest of the body is clear?
I hope someone else is able to help you with other terms. The weekend is often slow.
Linda
stage IV since 06 (presently 1 brain met)
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- June 2, 2012 at 3:44 pm
Primary Dermal Melanoma
http://www.ncbi.nlm.nih.gov/pubmed/14732666
Primary dermal melanoma: a distinct subtype of melanoma.
Source
Dermatology Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif., USA. [email protected]
Abstract
BACKGROUND:
The term primary dermal melanoma has been used to describe a subtype of melanoma confined to the dermis and/or subcutaneous fat that histologically simulates metastasis but is associated with an unexpectedly prolonged survival. We report 7 cases of primary dermal melanoma diagnosed from 1998 to 2002 with no identifiable junctional or epidermal component or nevoid precursor. Histopathologic and immunohistochemical features were compared with known cases of cutaneous metastasis and nodular melanoma in an attempt to differentiate this entity from clinical and pathologic mimics.
OBSERVATIONS:
Seven patients had a single dermal and/or subcutaneous focus of melanoma. Metastatic staging workup findings were negative, including results from sentinel node and imaging studies. Mean Breslow depth was 7.0 mm, and mean maximum tumor diameter was 6.2 mm. The study cohort showed 100% survival at mean follow-up of 41 months (range, 10-64 months). Immunohistochemical analysis with S100, HMB-45, Ki-67, CD34, and p75 antibodies showed no significant staining patterns compared with metastatic and nodular melanomas.
CONCLUSIONS:
Primary dermal melanoma appears to be a distinct subtype of melanoma based on the excellent prognosis associated with this case series and others. Additional research focusing on cause, appropriate staging, and outcome of previously identified solitary dermal metastasis is warranted to further delineate this entity.
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- June 2, 2012 at 3:44 pm
Primary Dermal Melanoma
http://www.ncbi.nlm.nih.gov/pubmed/14732666
Primary dermal melanoma: a distinct subtype of melanoma.
Source
Dermatology Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif., USA. [email protected]
Abstract
BACKGROUND:
The term primary dermal melanoma has been used to describe a subtype of melanoma confined to the dermis and/or subcutaneous fat that histologically simulates metastasis but is associated with an unexpectedly prolonged survival. We report 7 cases of primary dermal melanoma diagnosed from 1998 to 2002 with no identifiable junctional or epidermal component or nevoid precursor. Histopathologic and immunohistochemical features were compared with known cases of cutaneous metastasis and nodular melanoma in an attempt to differentiate this entity from clinical and pathologic mimics.
OBSERVATIONS:
Seven patients had a single dermal and/or subcutaneous focus of melanoma. Metastatic staging workup findings were negative, including results from sentinel node and imaging studies. Mean Breslow depth was 7.0 mm, and mean maximum tumor diameter was 6.2 mm. The study cohort showed 100% survival at mean follow-up of 41 months (range, 10-64 months). Immunohistochemical analysis with S100, HMB-45, Ki-67, CD34, and p75 antibodies showed no significant staining patterns compared with metastatic and nodular melanomas.
CONCLUSIONS:
Primary dermal melanoma appears to be a distinct subtype of melanoma based on the excellent prognosis associated with this case series and others. Additional research focusing on cause, appropriate staging, and outcome of previously identified solitary dermal metastasis is warranted to further delineate this entity.
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- June 2, 2012 at 3:44 pm
Primary Dermal Melanoma
http://www.ncbi.nlm.nih.gov/pubmed/14732666
Primary dermal melanoma: a distinct subtype of melanoma.
Source
Dermatology Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif., USA. [email protected]
Abstract
BACKGROUND:
The term primary dermal melanoma has been used to describe a subtype of melanoma confined to the dermis and/or subcutaneous fat that histologically simulates metastasis but is associated with an unexpectedly prolonged survival. We report 7 cases of primary dermal melanoma diagnosed from 1998 to 2002 with no identifiable junctional or epidermal component or nevoid precursor. Histopathologic and immunohistochemical features were compared with known cases of cutaneous metastasis and nodular melanoma in an attempt to differentiate this entity from clinical and pathologic mimics.
OBSERVATIONS:
Seven patients had a single dermal and/or subcutaneous focus of melanoma. Metastatic staging workup findings were negative, including results from sentinel node and imaging studies. Mean Breslow depth was 7.0 mm, and mean maximum tumor diameter was 6.2 mm. The study cohort showed 100% survival at mean follow-up of 41 months (range, 10-64 months). Immunohistochemical analysis with S100, HMB-45, Ki-67, CD34, and p75 antibodies showed no significant staining patterns compared with metastatic and nodular melanomas.
CONCLUSIONS:
Primary dermal melanoma appears to be a distinct subtype of melanoma based on the excellent prognosis associated with this case series and others. Additional research focusing on cause, appropriate staging, and outcome of previously identified solitary dermal metastasis is warranted to further delineate this entity.
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