Targeted drug attack problems – example from c-kit work
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Targeted drug attack problems – example from c-kit work

› Forums › General Melanoma Community › Targeted drug attack problems – example from c-kit work

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    • August 30, 2011 at 7:08 pm
    JerryfromFauq
    Participant

    http://mct.aacrjournals.org/content/6/3/1159.full

    Long article that discusses c-kit mutations and resistance to treatments.

    I would expect similar modes of findings in all of the targeted attacks on different mutations other than just c-kit.  This shows what the medical research is up against in attempting to narrow the attack on each mutation in each type of cancer (even within the different types of c-kit melanoma!).  

    The introduction, results and Discussion sections are especially interesting.
    Wish I had a better background to understand the details even better.

    The article sections are:
     

    Abstract

    Introduction

    Materials and Methods

    c-KIT Expression in FDC-P1 Cells

    c-KIT Kinase Inhibitory Drugs

    Immunofluorescence Assay

    Cell Proliferation Assay

    Immunoprecipitation and Western Blot Analysis

    Structural Analysis

    Results

    Expression Levels of c-KIT in FDC-P1 Cells

    Preliminary Studies with V654A Mutant c-KIT

    Effect of the V654A Substitution in Combination with V560G, an Activating Mutation Characteristic of GIST, on Drug Sensitivity

    Effect of Kinase Inhibitors on c-KIT Phosphorylation

    Discussion

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