Searching for nonrandomized anti PD-1 trial

Thanks for all the replies. I'll be getting on the phone again tomorrow, will start with the medical centers you folks pointed me to. I spoke with our research nurse at Sloan this morning and found that (as Karen says) the phase 1 trial is no longer an option and the Merck trial is no longer enrolling. I'm going to try to see if I can find another site still enrolling for one of those. In the trial our onc is recommending, there's no option for switching over. My husband's six-week CT after the ipi showed things still in flux–some growths larger, some smaller–so we waited another six weeks, and that scan showed more and larger growths in soft tissue plus larger ones in his lungs and a new one on a kidney. The BMS site is so helpful; I wish Merck's was, too. Tried phoning them for info and they pointed me back to their website, which tells you virtually nothing. Does anyone know if any other pharma cos. (besides BMS and Merck) are developing anti PD-1 drugs for melanoma?

Thanks for all the replies. I'll be getting on the phone again tomorrow, will start with the medical centers you folks pointed me to. I spoke with our research nurse at Sloan this morning and found that (as Karen says) the phase 1 trial is no longer an option and the Merck trial is no longer enrolling. I'm going to try to see if I can find another site still enrolling for one of those. In the trial our onc is recommending, there's no option for switching over. My husband's six-week CT after the ipi showed things still in flux–some growths larger, some smaller–so we waited another six weeks, and that scan showed more and larger growths in soft tissue plus larger ones in his lungs and a new one on a kidney. The BMS site is so helpful; I wish Merck's was, too. Tried phoning them for info and they pointed me back to their website, which tells you virtually nothing. Does anyone know if any other pharma cos. (besides BMS and Merck) are developing anti PD-1 drugs for melanoma?

Thanks for all the replies. I'll be getting on the phone again tomorrow, will start with the medical centers you folks pointed me to. I spoke with our research nurse at Sloan this morning and found that (as Karen says) the phase 1 trial is no longer an option and the Merck trial is no longer enrolling. I'm going to try to see if I can find another site still enrolling for one of those. In the trial our onc is recommending, there's no option for switching over. My husband's six-week CT after the ipi showed things still in flux–some growths larger, some smaller–so we waited another six weeks, and that scan showed more and larger growths in soft tissue plus larger ones in his lungs and a new one on a kidney. The BMS site is so helpful; I wish Merck's was, too. Tried phoning them for info and they pointed me back to their website, which tells you virtually nothing. Does anyone know if any other pharma cos. (besides BMS and Merck) are developing anti PD-1 drugs for melanoma?

I'm happy for you that you were able to get into the Merck PD 1 trial. I talked to a research nurse at NYU and was told that they're no longer enrolling for the nonrandomized phase 1 trial, only for the phase 2 trial randomized vs. chemotherapy.  The only advantage that offers us over the Sloan BMS trial is that the Merck trial has the possibility of crossover if you show results on the chemo. Still, it's an advantage and if my husband ends up in the chemo arm at Sloan and I haven't found anything else, we would probably opt out and try for the NYU trial instead. In the meantime I'm still phoning around, trying to find a nonrandomized trial.

Good luck to you!

Virginia

Thanks for all the replies. I'll be getting on the phone again tomorrow, will start with the medical centers you folks pointed me to. I spoke with our research nurse at Sloan this morning and found that (as Karen says) the phase 1 trial is no longer an option and the Merck trial is no longer enrolling. I'm going to try to see if I can find another site still enrolling for one of those. In the trial our onc is recommending, there's no option for switching over. My husband's six-week CT after the ipi showed things still in flux–some growths larger, some smaller–so we waited another six weeks, and that scan showed more and larger growths in soft tissue plus larger ones in his lungs and a new one on a kidney. The BMS site is so helpful; I wish Merck's was, too. Tried phoning them for info and they pointed me back to their website, which tells you virtually nothing. Does anyone know if any other pharma cos. (besides BMS and Merck) are developing anti PD-1 drugs for melanoma?

Thanks for all the replies. I'll be getting on the phone again tomorrow, will start with the medical centers you folks pointed me to. I spoke with our research nurse at Sloan this morning and found that (as Karen says) the phase 1 trial is no longer an option and the Merck trial is no longer enrolling. I'm going to try to see if I can find another site still enrolling for one of those. In the trial our onc is recommending, there's no option for switching over. My husband's six-week CT after the ipi showed things still in flux–some growths larger, some smaller–so we waited another six weeks, and that scan showed more and larger growths in soft tissue plus larger ones in his lungs and a new one on a kidney. The BMS site is so helpful; I wish Merck's was, too. Tried phoning them for info and they pointed me back to their website, which tells you virtually nothing. Does anyone know if any other pharma cos. (besides BMS and Merck) are developing anti PD-1 drugs for melanoma?

Thanks for all the replies. I'll be getting on the phone again tomorrow, will start with the medical centers you folks pointed me to. I spoke with our research nurse at Sloan this morning and found that (as Karen says) the phase 1 trial is no longer an option and the Merck trial is no longer enrolling. I'm going to try to see if I can find another site still enrolling for one of those. In the trial our onc is recommending, there's no option for switching over. My husband's six-week CT after the ipi showed things still in flux–some growths larger, some smaller–so we waited another six weeks, and that scan showed more and larger growths in soft tissue plus larger ones in his lungs and a new one on a kidney. The BMS site is so helpful; I wish Merck's was, too. Tried phoning them for info and they pointed me back to their website, which tells you virtually nothing. Does anyone know if any other pharma cos. (besides BMS and Merck) are developing anti PD-1 drugs for melanoma?

Thanks for all the replies. I'll be getting on the phone again tomorrow, will start with the medical centers you folks pointed me to. I spoke with our research nurse at Sloan this morning and found that (as Karen says) the phase 1 trial is no longer an option and the Merck trial is no longer enrolling. I'm going to try to see if I can find another site still enrolling for one of those. In the trial our onc is recommending, there's no option for switching over. My husband's six-week CT after the ipi showed things still in flux–some growths larger, some smaller–so we waited another six weeks, and that scan showed more and larger growths in soft tissue plus larger ones in his lungs and a new one on a kidney. The BMS site is so helpful; I wish Merck's was, too. Tried phoning them for info and they pointed me back to their website, which tells you virtually nothing. Does anyone know if any other pharma cos. (besides BMS and Merck) are developing anti PD-1 drugs for melanoma?

Thanks for all the replies. I'll be getting on the phone again tomorrow, will start with the medical centers you folks pointed me to. I spoke with our research nurse at Sloan this morning and found that (as Karen says) the phase 1 trial is no longer an option and the Merck trial is no longer enrolling. I'm going to try to see if I can find another site still enrolling for one of those. In the trial our onc is recommending, there's no option for switching over. My husband's six-week CT after the ipi showed things still in flux–some growths larger, some smaller–so we waited another six weeks, and that scan showed more and larger growths in soft tissue plus larger ones in his lungs and a new one on a kidney. The BMS site is so helpful; I wish Merck's was, too. Tried phoning them for info and they pointed me back to their website, which tells you virtually nothing. Does anyone know if any other pharma cos. (besides BMS and Merck) are developing anti PD-1 drugs for melanoma?

Thanks for all the replies. I'll be getting on the phone again tomorrow, will start with the medical centers you folks pointed me to. I spoke with our research nurse at Sloan this morning and found that (as Karen says) the phase 1 trial is no longer an option and the Merck trial is no longer enrolling. I'm going to try to see if I can find another site still enrolling for one of those. In the trial our onc is recommending, there's no option for switching over. My husband's six-week CT after the ipi showed things still in flux–some growths larger, some smaller–so we waited another six weeks, and that scan showed more and larger growths in soft tissue plus larger ones in his lungs and a new one on a kidney. The BMS site is so helpful; I wish Merck's was, too. Tried phoning them for info and they pointed me back to their website, which tells you virtually nothing. Does anyone know if any other pharma cos. (besides BMS and Merck) are developing anti PD-1 drugs for melanoma?

I'm happy for you that you were able to get into the Merck PD 1 trial. I talked to a research nurse at NYU and was told that they're no longer enrolling for the nonrandomized phase 1 trial, only for the phase 2 trial randomized vs. chemotherapy.  The only advantage that offers us over the Sloan BMS trial is that the Merck trial has the possibility of crossover if you show results on the chemo. Still, it's an advantage and if my husband ends up in the chemo arm at Sloan and I haven't found anything else, we would probably opt out and try for the NYU trial instead. In the meantime I'm still phoning around, trying to find a nonrandomized trial.

Good luck to you!

Virginia

I'm happy for you that you were able to get into the Merck PD 1 trial. I talked to a research nurse at NYU and was told that they're no longer enrolling for the nonrandomized phase 1 trial, only for the phase 2 trial randomized vs. chemotherapy.  The only advantage that offers us over the Sloan BMS trial is that the Merck trial has the possibility of crossover if you show results on the chemo. Still, it's an advantage and if my husband ends up in the chemo arm at Sloan and I haven't found anything else, we would probably opt out and try for the NYU trial instead. In the meantime I'm still phoning around, trying to find a nonrandomized trial.

Good luck to you!

Virginia