Opdivo
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Opdivo

› Forums › General Melanoma Community › Opdivo

  • Post
    • December 30, 2018 at 3:47 pm
    Mitchell
    Participant
    July of this year my oncologist put me on a opdivo. Ever since that point my world has come Crashing Down around me. I have I’m going to metastasized tumor in my groin and within two infusions it grew from a tumor the size of a teacup to a tumor the size of a large dinner plate. My question is has anyone experienced the same problem with a Apdivo having reverse results?
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      • December 30, 2018 at 4:16 pm
      ed williams
      Participant

      Hi Mitchell, hyperprogression is not a new problem, it has been reported for years with other immunotherapy drugs like ipi and IL-2. Here is an ASCO post talking about the experience in one hospital in Toronto Canada over 6 year period of time. % is not large and results for patients doesn't seem to change compared to rest of population being treated. I have a second article that is specific to Pd-1 drugs but it is current and from Nature so I only have the introduction, if you want to read the whole thing you have to buy the article or you could ask you Oncologist at Md Anderson to print it off for you, I am sure they would have free access to Nature. http://ascopubs.org/doi/abs/10.1200/JCO.2018.36.15_suppl.3063             https://www.nature.com/articles/s41571-018-0111-2?WT.feed_name=subjects_cancer-immunotherapy

      • December 31, 2018 at 12:58 am
      lkb
      Participant

      I've had progression on Opdivo–tumor has grown to the size of a blueberry, but might now be shrinking. Hope to get re-measured in early January.

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