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NRAS Mutation- help on the way?
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NRAS Mutation- help on the way?

› Forums › Cutaneous Melanoma Community › NRAS Mutation- help on the way?

  • Post
    • May 30, 2021 at 3:44 am
    tim brown
    Participant
      One for Ed, Celeste and the boffins:

      Like 20% of BRAF wild types, I have the NRAS tumor mutation. I failed on adjuvant PD1 and I am recovering from further surgery on the axilla in early March. This mutation is generally bad news when immunotherapy fails. One oncologist researcher famously deemed NRAS to be it ‘undruggable’. (Admittedly, MEK inhibition drugs have a marginal effect)

      I had a consultation with a junior oncologist last week and was bemoaning my NRAS status when she said words to the effect of   ‘It ain’t necessarily so’.  I dismissed this as a platitude then we moved on to other matters. The following day I saw a report about FDA approval for a KRAS targeted drug in NSCLC.  The article mentioned how KRAS mutations (from the same RAS family) had been viewed as a basket case as  well. Might this mean that the key to the door has been found?

       

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