tim brownParticipantOne for Ed, Celeste and the boffins:
- May 30, 2021 at 3:44 am
Like 20% of BRAF wild types, I have the NRAS tumor mutation. I failed on adjuvant PD1 and I am recovering from further surgery on the axilla in early March. This mutation is generally bad news when immunotherapy fails. One oncologist researcher famously deemed NRAS to be it ‘undruggable’. (Admittedly, MEK inhibition drugs have a marginal effect)
I had a consultation with a junior oncologist last week and was bemoaning my NRAS status when she said words to the effect of ‘It ain’t necessarily so’. I dismissed this as a platitude then we moved on to other matters. The following day I saw a report about FDA approval for a KRAS targeted drug in NSCLC. The article mentioned how KRAS mutations (from the same RAS family) had been viewed as a basket case as well. Might this mean that the key to the door has been found?
ThreefittyParticipantJust one person’s experience. Braf wild/NRAS positive. My MD mentioned an NRAS related trial he is involved in (U Miami/Sylvester.)
- May 30, 2021 at 2:50 pm
I would be possibly heading for it myself, but I am still having some response to immuno. (Not clear which side of combo or both or if it will continue).
I’m bucking for a TIL CT if progression returns as our other Tim has written of recently.
Mark_DCParticipantDear Tim and threefifty, you may want to post in the general melanoma community forum as maybe Celeste and Ed dont read this sub forum (too many forums!)
- June 14, 2021 at 9:13 pm
I am NRAS and BRAF wild type – at first there were some papers saying immunotherapy worked better for NRAS but i think this was incorrect. For me pembro slowed progression and spread but didnt really work; adding TVEC really helped. I too follow any NRAS treatment developments (I read about KRAS too recently like you) so please keep us posted but maybe on the main forum?
good luck Mark
I just joined this forum as caregiver for my 75 yr old dad. Initial spot removed from forearm March 2020. PET scans good until Nov 2021. Metastasized to lung, surgically removed, margins and lymph nodes clear. Brain MRI results today clear. BUT oncologist estimates he has 6 months to live because it is NRAS mutation. She told him if it were her dad, she would say “wait and see” if it spreads before starting immunotherapy because “quality of life” for those 6 months. Meaning it’s hopeless. I’m looking for hope – any kind of feedback on NRAS treatment or specialists. I adore my dad and am heartbroken. Thank you and my best to everyone battling this.
- March 30, 2022 at 9:48 pm
Marn, this is some of the recent research and trials going on with NRAS mutation in melanoma. https://aacrjournals.org/clincancerres/article/doi/10.1158/1078-0432.CCR-21-3872/682197/Phase-Ib-II-Trial-of-Ribociclib-in-Combination https://aacrjournals.org/clincancerres/article/27/7/2061/671905/LXH254-a-Potent-and-Selective-ARAF-Sparing?fbclid=IwAR0xRWucYJPNX9xDTNgGLdMzTFe4wZgUXc5-Rtbj94af5_47lD_F0ZPbbu4 https://clinicaltrials.gov/ct2/show/NCT04417621
- March 31, 2022 at 9:31 am
Also, in development and something to look into is new drug company with NRAS melanoma drug prospect. https://ir.immuneering.com/news-releases/news-release-details/immuneering-reports-compelling-preclinical-data-imm-1-104-nras https://ir.immuneering.com/node/7076/pdf
- March 31, 2022 at 9:33 am
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