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Like 20% of BRAF wild types, I have the NRAS tumor mutation. I failed on adjuvant PD1 and I am recovering from further surgery on the axilla in early March. This mutation is generally bad news when immunotherapy fails. One oncologist researcher famously deemed NRAS to be it ‘undruggable’. (Admittedly, MEK inhibition drugs have a marginal effect)
I had a consultation with a junior oncologist last week and was bemoaning my NRAS status when she said words to the effect of ‘It ain’t necessarily so’. I dismissed this as a platitude then we moved on to other matters. The following day I saw a report about FDA approval for a KRAS targeted drug in NSCLC. The article mentioned how KRAS mutations (from the same RAS family) had been viewed as a basket case as well. Might this mean that the key to the door has been found?
Dear Tim and threefifty, you may want to post in the general melanoma community forum as maybe Celeste and Ed dont read this sub forum (too many forums!)
I am NRAS and BRAF wild type – at first there were some papers saying immunotherapy worked better for NRAS but i think this was incorrect. For me pembro slowed progression and spread but didnt really work; adding TVEC really helped. I too follow any NRAS treatment developments (I read about KRAS too recently like you) so please keep us posted but maybe on the main forum?
good luck Mark
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