Nivolumab to Pembrolizumab?
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Nivolumab to Pembrolizumab?

› Forums › General Melanoma Community › Nivolumab to Pembrolizumab?

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    • July 30, 2018 at 12:54 am
    Newcalgal
    Participant

    Hello there MRF community, 

    I'm new here and am trying to find some info for my mum, recently diagnosed with stage IV melanoma (not with BRAF) which has spread from being stage 3 in a lymph gland to organs whilst undergoing Nivolumab treatment. A next possible treatment is Pembrolizumab. My question is, is there any research (or personal experiences) regarding people being treated by Nivolumab with disease progression who then have better outcomes using Prembrolizumab? I have been reading resarch articles on the various immunotherapy treatments and I can't really find an answer to this question. I can find some research summaries that talk about how some patients do not respond to immumnotherapies at all. Is it better to go and have radiation? But then how does radiation of a tumor help when the disease has spread to the organs? And is it possible to have disease progression whilst undergoing Nivolumab but then disease improvement (halting spread? please excuse my crappy expression of technical terms – I'm muddling through, not knowing much!) when using Nivolumab and Ipilimumab combined?

     

    For the sake of ease – my 2 questions are:

    1. If you have disease progression (stage 3 to 4) during treatment of Nivolumab, is it possible to have positive outcomes using Pembrolizumab?

    2. If you have disease progression from stage 3 to 4 during Nivolumab treatment, is it possible to have positive outcomes using the combination treatment of Novolumab and Ipilimumab + radiation (of lymph tumor)?

    Thanks for reading 🙂 I'd love to hear any info you have or any research you may be able to point me towards

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  • Replies
      • July 30, 2018 at 1:01 pm
      ed williams
      Participant

      Hi Newcalgal, first question is kind of hard to answer since most melanoma patients will either start with combination of Ipi/Nivo or a Pd-1 (nivo or pembro) . The two Pd-1 drugs have never been compared to my knowledge head to head, you might find some case studies where a patients goes from nivo to pembro, but I haven't come across any. Now adding ipi after Nivo or Pembro has data and has been looked at before, I have a link for you from two years ago, and they get into the topic in detail. Second video that I am going to give you is from last fall ESMO conference and the topic is what new options are out there, clinical trial stuff. Some thing to remember is Pembro+ Ido failed in trial.  Best wishes!!!Ed  https://www.youtube.com/watch?v=eeJp_TKiv54        https://www.youtube.com/watch?v=yrNef97azaA

      • July 30, 2018 at 11:51 pm
      Bubbles
      Participant

      Ed gave you some good info.  Here is a primer that I put together that may help you:  https://chaoticallypreciselifeloveandmelanoma.blogspot.com/2017/08/melanoma-intel-primer-for-current.html

      I wish you and your mom my best.  Celeste

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