Good News: MEK162/CDK4 trial
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Good News: MEK162/CDK4 trial

› Forums › General Melanoma Community › Good News: MEK162/CDK4 trial

  • Post
    • October 23, 2014 at 2:52 am
    FayFighter
    Participant

    I have come to this site for hope countless times. Hoping this post helps someone like you all have helped me. A shout out to Celeste who originally planted the seed regarding this trial.

    CT scan today (8 wks out) show 30% reduction in liver lesions. 

    Thank you.

    Angela

     

    Recap re my husbands diagnosis:

    july 2010 melanocytic nevi Lower left calf excised (later in 2014 reread by mskcc as melanoma in situ)
     
    derm exams/6 mos
     
    June 2013 small nodules by excision (we had no idea we should be looking for anything like this and thought it was a vericose vein)
     
    July 2013 bump in groin. Biopsy shows it's melanoma.
     
    Mid August 2013 lymphadenectomy (5/19 positive) and excision of lower leg nodules.
     
    oct 2013 start yervoy and gets all 4 cycles.  Colon issues require heavy prednisone and 2 remicades.
     
    radiation of lymph basin nov/dec
     
    january 2014 tumor profile NRAS pos BRAF neg
     
    march 2013 finally tapering of prednisone
     
    April 2014 pet shows lesion in stomach (3.5 cm) and little nodule in groin and at lower left calf.
     
    may 21 start anti pd1 and KIR trial. 
     
    July 2014 stomach lesion 6cm/liver lesions detected
     
    july 20 surgery to remove stomach lesion
     
    aug 20 start mek162/cdk4 trial liver lesions have shown progression since july
     
    todays scans: liver lesions reduced by 30 percent
     
     
Viewing 14 reply threads
  • Replies
      • October 23, 2014 at 1:42 pm
      tschmith
      Participant

      Love hearing good news!  Progress is being made and lots of reason to hope for even more effective treatments.

      Hurrah!

      Terrie

      • October 23, 2014 at 1:42 pm
      tschmith
      Participant

      Love hearing good news!  Progress is being made and lots of reason to hope for even more effective treatments.

      Hurrah!

      Terrie

      • October 23, 2014 at 1:42 pm
      tschmith
      Participant

      Love hearing good news!  Progress is being made and lots of reason to hope for even more effective treatments.

      Hurrah!

      Terrie

      • October 23, 2014 at 4:26 pm
      arthurjedi007
      Participant

      That sounds wonderful Angela for you and your husband.

      Artie

      • October 23, 2014 at 4:26 pm
      arthurjedi007
      Participant

      That sounds wonderful Angela for you and your husband.

      Artie

      • October 23, 2014 at 4:26 pm
      arthurjedi007
      Participant

      That sounds wonderful Angela for you and your husband.

      Artie

      • October 23, 2014 at 11:04 pm
      Bubbles
      Participant

      Oh, Angela. You  made me cry…in the best way ever!!!!  30% reduction in liver lesions at 8 weeks!! That's WONDERFUL! I am so happy for you and your husband! Thanks for sharing with me and everyone else that they may benefit as well. Yours, celeste

        • October 24, 2014 at 2:44 pm
        ed williams
        Participant

        Celeste you have my vote for Melanoma Blogger of the year!!! Keep up the good work. Ed

        • October 24, 2014 at 2:44 pm
        ed williams
        Participant

        Celeste you have my vote for Melanoma Blogger of the year!!! Keep up the good work. Ed

        • October 24, 2014 at 2:44 pm
        ed williams
        Participant

        Celeste you have my vote for Melanoma Blogger of the year!!! Keep up the good work. Ed

      • October 23, 2014 at 11:04 pm
      Bubbles
      Participant

      Oh, Angela. You  made me cry…in the best way ever!!!!  30% reduction in liver lesions at 8 weeks!! That's WONDERFUL! I am so happy for you and your husband! Thanks for sharing with me and everyone else that they may benefit as well. Yours, celeste

      • October 23, 2014 at 11:04 pm
      Bubbles
      Participant

      Oh, Angela. You  made me cry…in the best way ever!!!!  30% reduction in liver lesions at 8 weeks!! That's WONDERFUL! I am so happy for you and your husband! Thanks for sharing with me and everyone else that they may benefit as well. Yours, celeste

      • October 24, 2014 at 1:46 am
      BrianP
      Participant

      Awesome news Angela.  You guys were definitely due for some good news. 

      Can you list the trial identifier when you get a chance.

      Brian

        • October 29, 2014 at 2:26 am
        FayFighter
        Participant

        Hi Brian. And thanks for all your advice/help over the past year. I am so lucky to have found this site.  

        Novartis CMEK162X2114, version 2 phase 1b. Study of LEE011 with MEK162 in adult pts with NRASmutant melanoma. 

        • October 29, 2014 at 2:26 am
        FayFighter
        Participant

        Hi Brian. And thanks for all your advice/help over the past year. I am so lucky to have found this site.  

        Novartis CMEK162X2114, version 2 phase 1b. Study of LEE011 with MEK162 in adult pts with NRASmutant melanoma. 

        • October 29, 2014 at 2:26 am
        FayFighter
        Participant

        Hi Brian. And thanks for all your advice/help over the past year. I am so lucky to have found this site.  

        Novartis CMEK162X2114, version 2 phase 1b. Study of LEE011 with MEK162 in adult pts with NRASmutant melanoma. 

      • October 24, 2014 at 1:46 am
      BrianP
      Participant

      Awesome news Angela.  You guys were definitely due for some good news. 

      Can you list the trial identifier when you get a chance.

      Brian

      • October 24, 2014 at 1:46 am
      BrianP
      Participant

      Awesome news Angela.  You guys were definitely due for some good news. 

      Can you list the trial identifier when you get a chance.

      Brian

      • October 29, 2014 at 6:14 pm
      kylez
      Participant

      Angela, this must be super encouraging. 30% in 8 weeks. You're a pioneer for NRAS patients like me. It must take some guts and faith to sign up for a trial that's not yet known to have a 'buzz' — like PD1 must have been at its beginning. When I read your news I also thought, sounds like a promising plan B for me too. 

      I've been able stay in that PD1 / Kir trial. At the 32-week mark (scanned this Monday) the radiologist noted a minimal decrease in size — first time they've seen shrinkage, even if a tiny bit.

       

        • October 29, 2014 at 6:18 pm
        kylez
        Participant

        I mean, um, your husband's a pioneer! (and you with him).

        • October 30, 2014 at 12:58 am
        FayFighter
        Participant

        Kyle,

        In the car with Mike (my husband) and your post made him smile. Being NRAS is like being the stepchild at times.  We are over the moon about his response. (Between me and you) I did my own calculations and I think the reduction is actually greater.  I am excited for us but excited for everyone who may benefit some day. Two breathes after we got the results of CT, I asked about others and they said they are happy with the results so far. If could be the CDK4 or the MeK or both. It's just refreshing.  I can't believe I am driving to NJ with my sweetheart to Ohio with our two small children to celebrate the wedding of my cousin.  It's just fantastic. 

        Keep us posted on your status. All the best. 

        Angela 

        • October 30, 2014 at 12:58 am
        FayFighter
        Participant

        Kyle,

        In the car with Mike (my husband) and your post made him smile. Being NRAS is like being the stepchild at times.  We are over the moon about his response. (Between me and you) I did my own calculations and I think the reduction is actually greater.  I am excited for us but excited for everyone who may benefit some day. Two breathes after we got the results of CT, I asked about others and they said they are happy with the results so far. If could be the CDK4 or the MeK or both. It's just refreshing.  I can't believe I am driving to NJ with my sweetheart to Ohio with our two small children to celebrate the wedding of my cousin.  It's just fantastic. 

        Keep us posted on your status. All the best. 

        Angela 

        • October 30, 2014 at 12:58 am
        FayFighter
        Participant

        Kyle,

        In the car with Mike (my husband) and your post made him smile. Being NRAS is like being the stepchild at times.  We are over the moon about his response. (Between me and you) I did my own calculations and I think the reduction is actually greater.  I am excited for us but excited for everyone who may benefit some day. Two breathes after we got the results of CT, I asked about others and they said they are happy with the results so far. If could be the CDK4 or the MeK or both. It's just refreshing.  I can't believe I am driving to NJ with my sweetheart to Ohio with our two small children to celebrate the wedding of my cousin.  It's just fantastic. 

        Keep us posted on your status. All the best. 

        Angela 

        • October 29, 2014 at 6:18 pm
        kylez
        Participant

        I mean, um, your husband's a pioneer! (and you with him).

        • October 29, 2014 at 6:18 pm
        kylez
        Participant

        I mean, um, your husband's a pioneer! (and you with him).

      • October 29, 2014 at 6:14 pm
      kylez
      Participant

      Angela, this must be super encouraging. 30% in 8 weeks. You're a pioneer for NRAS patients like me. It must take some guts and faith to sign up for a trial that's not yet known to have a 'buzz' — like PD1 must have been at its beginning. When I read your news I also thought, sounds like a promising plan B for me too. 

      I've been able stay in that PD1 / Kir trial. At the 32-week mark (scanned this Monday) the radiologist noted a minimal decrease in size — first time they've seen shrinkage, even if a tiny bit.

       

      • October 29, 2014 at 6:14 pm
      kylez
      Participant

      Angela, this must be super encouraging. 30% in 8 weeks. You're a pioneer for NRAS patients like me. It must take some guts and faith to sign up for a trial that's not yet known to have a 'buzz' — like PD1 must have been at its beginning. When I read your news I also thought, sounds like a promising plan B for me too. 

      I've been able stay in that PD1 / Kir trial. At the 32-week mark (scanned this Monday) the radiologist noted a minimal decrease in size — first time they've seen shrinkage, even if a tiny bit.

       

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