Does new lesion on hip mean Keytruda is no longer working for me ?
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Does new lesion on hip mean Keytruda is no longer working for me ?

› Forums › General Melanoma Community › Does new lesion on hip mean Keytruda is no longer working for me ?

  • Post
    • January 22, 2015 at 11:21 pm
    arthurjedi007
    Participant

    Among everything else I'm dealing with they found out the reason my right hip was hurting a lot is because the hip ct yesterday showed a lesion there. He said that was not there on my November petct scan. Since I've been on keytruda since May with a few tumors showing minor growth but no new tumors and other tumors shrinking does this now mean keytruda is failing me so if I get through my current issues I gotta get on a different systemic treatment fast? radiation to hip starts soon to end at same time as rest of radiation.

    Artie

Viewing 11 reply threads
  • Replies
      • January 23, 2015 at 3:30 am
      mom123
      Participant

      Hi Artie,

       

      I dont think so. Occasionaly, it is an "old" tumor that is going through pseudo-progression before it shrinks. Actually most of the tumors on hodi and Wolcok paper:"Guidelines for evaluation of immune therapy.." http://clincancerres.aacrjournals.org/content/15/23/7412 shows growth and than shrinkage (Fig.1)

       

      whishing you all the best,

      mom 

       

      • January 23, 2015 at 3:30 am
      mom123
      Participant

      Hi Artie,

       

      I dont think so. Occasionaly, it is an "old" tumor that is going through pseudo-progression before it shrinks. Actually most of the tumors on hodi and Wolcok paper:"Guidelines for evaluation of immune therapy.." http://clincancerres.aacrjournals.org/content/15/23/7412 shows growth and than shrinkage (Fig.1)

       

      whishing you all the best,

      mom 

       

      • January 23, 2015 at 3:30 am
      mom123
      Participant

      Hi Artie,

       

      I dont think so. Occasionaly, it is an "old" tumor that is going through pseudo-progression before it shrinks. Actually most of the tumors on hodi and Wolcok paper:"Guidelines for evaluation of immune therapy.." http://clincancerres.aacrjournals.org/content/15/23/7412 shows growth and than shrinkage (Fig.1)

       

      whishing you all the best,

      mom 

       

      • January 23, 2015 at 4:01 pm
      Bubbles
      Participant

      Oh, Artie! 

      I'm not sure.  I guess Mom is possibly correct, that this is enlargement of not necessarily tumor but infiltrates around it.  However, you have always been proactive and I'd probably be talking to the docs about how they see it and if they think it is time to be looking at the LAG-3 trials, TIL, etc.  I am still holding out for some synergistic effect between your current and upcoming radiation treatments and Keytruda!!!  How is your swallowing?  Are you seeing any improvement there?  Much love, c

      • January 23, 2015 at 4:01 pm
      Bubbles
      Participant

      Oh, Artie! 

      I'm not sure.  I guess Mom is possibly correct, that this is enlargement of not necessarily tumor but infiltrates around it.  However, you have always been proactive and I'd probably be talking to the docs about how they see it and if they think it is time to be looking at the LAG-3 trials, TIL, etc.  I am still holding out for some synergistic effect between your current and upcoming radiation treatments and Keytruda!!!  How is your swallowing?  Are you seeing any improvement there?  Much love, c

      • January 23, 2015 at 4:01 pm
      Bubbles
      Participant

      Oh, Artie! 

      I'm not sure.  I guess Mom is possibly correct, that this is enlargement of not necessarily tumor but infiltrates around it.  However, you have always been proactive and I'd probably be talking to the docs about how they see it and if they think it is time to be looking at the LAG-3 trials, TIL, etc.  I am still holding out for some synergistic effect between your current and upcoming radiation treatments and Keytruda!!!  How is your swallowing?  Are you seeing any improvement there?  Much love, c

        • January 23, 2015 at 5:18 pm
        arthurjedi007
        Participant

        Thanks Celeste. No swallowing improvement yet. Radiation doc hopes to see some improvement this time next week. I've lost 3 pounds this week so far but I'm trying hard.

        Artie

        • January 24, 2015 at 2:26 am
        Bubbles
        Participant

        Hang in there!  I hope you start seeing some improvements soon.  I know you are more than sick of it!!!  You have always tried hard and in so doing….inspired us all.  c

        • January 24, 2015 at 2:26 am
        Bubbles
        Participant

        Hang in there!  I hope you start seeing some improvements soon.  I know you are more than sick of it!!!  You have always tried hard and in so doing….inspired us all.  c

        • January 24, 2015 at 2:26 am
        Bubbles
        Participant

        Hang in there!  I hope you start seeing some improvements soon.  I know you are more than sick of it!!!  You have always tried hard and in so doing….inspired us all.  c

        • January 23, 2015 at 5:18 pm
        arthurjedi007
        Participant

        Thanks Celeste. No swallowing improvement yet. Radiation doc hopes to see some improvement this time next week. I've lost 3 pounds this week so far but I'm trying hard.

        Artie

        • January 23, 2015 at 5:18 pm
        arthurjedi007
        Participant

        Thanks Celeste. No swallowing improvement yet. Radiation doc hopes to see some improvement this time next week. I've lost 3 pounds this week so far but I'm trying hard.

        Artie

      • January 24, 2015 at 5:00 am
      JoshF
      Participant

      Artie-

      I certainly hope it doesn't mean it's stopped working. What does onc say? Praying that all goes well with radiation and Keytruda…get some relief on neck tumors etc…

      Josh

      • January 24, 2015 at 5:00 am
      JoshF
      Participant

      Artie-

      I certainly hope it doesn't mean it's stopped working. What does onc say? Praying that all goes well with radiation and Keytruda…get some relief on neck tumors etc…

      Josh

      • January 24, 2015 at 5:00 am
      JoshF
      Participant

      Artie-

      I certainly hope it doesn't mean it's stopped working. What does onc say? Praying that all goes well with radiation and Keytruda…get some relief on neck tumors etc…

      Josh

      • January 26, 2015 at 10:12 pm
      JustMeInCA
      Participant

      Artie, I won't go into all the details of what I already posted earlier today, but from what my dad's oncologist at UCSF said, new tumors or significant growth after starting Keytruda does not bode well. When pushed for a prognosis, he said we're talking months in my dad's case, that he's not at the super advanced stage, but that the doctor wouldn't want to postpone a change in treatment for more than a few weeks. 

      However, perhaps the radiation would make the difference in how well the lesion will respond to Keytruda now. I'd think that's very possible and is something to ask your doctor about before switching treatments. 

      On another note, with the crisis my dad suffered that day, I didn't have a chance to investigate that trial we had talked about. I will still try, though, as things hopefully continue to improve with Dad. 

      • January 26, 2015 at 10:12 pm
      JustMeInCA
      Participant

      Artie, I won't go into all the details of what I already posted earlier today, but from what my dad's oncologist at UCSF said, new tumors or significant growth after starting Keytruda does not bode well. When pushed for a prognosis, he said we're talking months in my dad's case, that he's not at the super advanced stage, but that the doctor wouldn't want to postpone a change in treatment for more than a few weeks. 

      However, perhaps the radiation would make the difference in how well the lesion will respond to Keytruda now. I'd think that's very possible and is something to ask your doctor about before switching treatments. 

      On another note, with the crisis my dad suffered that day, I didn't have a chance to investigate that trial we had talked about. I will still try, though, as things hopefully continue to improve with Dad. 

        • January 27, 2015 at 1:32 am
        arthurjedi007
        Participant

        Thank you for taking the time and thinking of me. You have your hands full. I posted to your post a little ago. I wish so much good luck to you and your dad.

        Artie

        • January 27, 2015 at 1:32 am
        arthurjedi007
        Participant

        Thank you for taking the time and thinking of me. You have your hands full. I posted to your post a little ago. I wish so much good luck to you and your dad.

        Artie

        • January 28, 2015 at 12:12 pm
        Maureen038
        Participant

        Artie,

         Hang in there!! I truly hope that the Keytruda is still working. Please keep us updated Artie!

        Maureen

        • January 28, 2015 at 12:12 pm
        Maureen038
        Participant

        Artie,

         Hang in there!! I truly hope that the Keytruda is still working. Please keep us updated Artie!

        Maureen

        • January 28, 2015 at 12:12 pm
        Maureen038
        Participant

        Artie,

         Hang in there!! I truly hope that the Keytruda is still working. Please keep us updated Artie!

        Maureen

        • January 27, 2015 at 1:32 am
        arthurjedi007
        Participant

        Thank you for taking the time and thinking of me. You have your hands full. I posted to your post a little ago. I wish so much good luck to you and your dad.

        Artie

      • January 26, 2015 at 10:12 pm
      JustMeInCA
      Participant

      Artie, I won't go into all the details of what I already posted earlier today, but from what my dad's oncologist at UCSF said, new tumors or significant growth after starting Keytruda does not bode well. When pushed for a prognosis, he said we're talking months in my dad's case, that he's not at the super advanced stage, but that the doctor wouldn't want to postpone a change in treatment for more than a few weeks. 

      However, perhaps the radiation would make the difference in how well the lesion will respond to Keytruda now. I'd think that's very possible and is something to ask your doctor about before switching treatments. 

      On another note, with the crisis my dad suffered that day, I didn't have a chance to investigate that trial we had talked about. I will still try, though, as things hopefully continue to improve with Dad. 

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