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Concerned about Mets in Spine

This topic has 4 replies, 3 voices, and was last updated 8 years, 6 months ago by rabbits68.

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- June 2, 2017 at 7:05 pm
- Quote
rabbits68
Participant

I have just started a Clinical Trial with Utomilumab at Sloan Kettering. Has anyone heard of or been on this drug? . I have progressed on other therapies and chemo. I have been having alot of back pain and the MRI showed bone mets from thoracic down to sacrum. One of the tumors is sitting on a nerve. I am feeling discouraged about so much bone involvement. I also have in my pelvis and femur. Anyone have good reports of regression in bone tumors? I am hoping the travelling and trial will be worth the time, money and exhaustion.

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- - June 2, 2017 at 9:02 pm
  - Quote
  Bubbles
  Participant
  
  This is all I have on it (and you may have already seen this for yourself): http://www.targetedonc.com/conference/asco-immune-2016/utomilumabpembrolizumab-combo-shows-responses-in-different-solid-tumors
  
  Hang in there! I wish you well. Celeste
  - June 2, 2017 at 9:24 pm
    
    Quote
    rabbits68
    Participant
    
    I hadn’t seen that post specifically, thanks for the information. I like to see they had a melanoma patient, was wondering if there were any. I’m not sure if there is still Keytruda in my system but hopefully I’m getting the combined benefits. I guess time will tell if this is worthwhile.
  - June 3, 2017 at 2:05 am
    
    Quote
    ed williams
    Participant
    
    Hi Lisa G, I found this article about 41-BB (CD-137) from 2015. Hope it helps!!!Ed https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459101/
  - June 3, 2017 at 5:30 am
    
    Quote
    rabbits68
    Participant
    
    This is encouraging although it sounds like monotherapy is less effective as combo therapy. I know my doctor wanted to start with the trial with the least toxicities. I am still hopeful my body responds to this. Thank you for finding that information it was helpful.

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