Baseline Tumor Size as an Independent prognostic indicator
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Baseline Tumor Size as an Independent prognostic indicator

› Forums › General Melanoma Community › Baseline Tumor Size as an Independent prognostic indicator

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    • January 24, 2019 at 8:47 pm
    ed williams
    Participant

    Recent article from some of the top melanoma oncologist looking at relationship to Tumor size and overall survival in early Pembro (Pd-1 ) trial. This is an interesting starting point on research into Tumor size being used as an independent indicator in overall survival with stage 4 melanoma. http://clincancerres.aacrjournals.org/content/24/20/4960

     

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      • January 24, 2019 at 9:39 pm
      Bubbles
      Participant

      Yes, I found that article interesting, too.  Funny thing is that it was published in April as well.  I think that is odd, but I included my thoughts here for those interested: 

       https://chaoticallypreciselifeloveandmelanoma.blogspot.com/2018/04/baseline-tumor-size-and-os-in-melanoma.html  

      Annnnnd….the same authors were cogitating on this back in 2014!!  See the 4th article in this post:

      https://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/06/mk-3475-mercks-anti-pd1-for.html  

      For what it's worth.  c

      • January 24, 2019 at 11:31 pm
      AMcReader
      Participant

      This might be a stupid question but do either of you know if Baseline Tumor Size would include tumors that were extracted prior to starting immunotherapy?

      • January 24, 2019 at 11:31 pm
      AMcReader
      Participant

      This might be a stupid question but do either of you know if Baseline Tumor Size would include tumors that were extracted prior to starting immunotherapy?

      • January 25, 2019 at 1:24 pm
      Bubbles
      Participant

      Given this line:  "583 of 655 patients had baseline measurable disease and were included in this post hoc analysis."  ~ it would seem that these are Stage IV patients and the disease burden is that which is within their bodies.  To your concern (?), you might find it interesting to know that we have long known that decreasing the tumor burden….whether by surgery, shrinking it with targeted therapy, debulking it with radiation…makes immunotherapy much more effective.  I liken it to an infection being treated with antibiotics.  If we have a mild ear infection or strep throat, basic treatment with antibiotics can kill the germs that are attacking us.  However, if our body has overwhelming infection (sepsis) the chances of getting antibiotics to kill all the germs at that point is much decreased.

      Hope that helps.  Celeste

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