The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Content within the patient forum is user-generated and has not been reviewed by medical professionals. Other sections of the Melanoma Research Foundation website include information that has been reviewed by medical professionals as appropriate. All medical decisions should be made in consultation with your doctor or other qualified medical professional.

Re: Recurrences with brain mets from BRAF/MEK Drugs?

Forums General Melanoma Community Recurrences with brain mets from BRAF/MEK Drugs? Re: Recurrences with brain mets from BRAF/MEK Drugs?


      It is too early to understand the relationship between working inhibitors and subsequent brain mets. The trials are too recent. But what little information we have, both from patients here and other sources, suggests that many people who have met with initial success on the Braf, develop brain mets some time later. The obvious reason would be that current inhibitor drugs don’t yet work in this area. What I find particularly disturbing is the possibility that inhibiting the spread of melanoma in one area might inadvertently increase the chances of it spreading to another, in this  case to the brain or CNS generally.  The melanoma wants to spread, so it finds a way. I am sure researchers will find a solution, some version of inhibitor that works in the CNS areas as well as everywhere else.

      In the meanwhile, people who are Braf or Mek positive should still see the inhibitors as a good option for them, as it may buy them significant time while the research advances. Every treatment has risks, and any patient on any treatment, not just inhibitors, might eventually see spread to the brain. Brain mets can be treated, and patients can move on to IPI or something else. It’s always a crap shot, but there is always hope.

    About the MRF Patient Forum

    The MRF Patient Forum is the oldest and largest online community of people affected by melanoma. It is designed to provide peer support and information to caregivers, patients, family and friends. There is no better place to discuss different parts of your journey with this cancer and find the friends and support resources to make that journey more bearable.

    The information on the forum is open and accessible to everyone. To add a new topic or to post a reply, you must be a registered user. Please note that you will be able to post both topics and replies anonymously even though you are logged in. All posts must abide by MRF posting policies.