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Yervoy and mucosal melanoma?
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Yervoy and mucosal melanoma?

› Forums › Mucosal Melanoma Community › Yervoy and mucosal melanoma?

  • Post
    • August 14, 2014 at 2:21 am
    CHD
    Participant

      Does anyone have any idea of how effective yervoy is with mucosal melanoma?  Links to current research and/or personal experience would be much appreciated.  I am having a hard time finding anything about this.

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    • Replies
        • August 14, 2014 at 4:54 am
        JerryfromFauq
        Participant

          I have not been able to find any statistics on Ipi (Yervoy) specific to any particular mutation.  Mucosal melanoma is not just one type.  My mucosal is C-kit.  The across the eboard response in around 20-25 % positive for all mutations lumped togeether.  The IL-2 immunotheropy was reported in Dec by the NIH to have a 47% positive response rate against NRAS melanoma mutations.  if one has the C-kit exon 11 mutation, Gleevec (Imatinb Mesylate) and others on that line (against other c-kit exon mutations) have recently been found to be an effective cytostatic treatment to often stop ones melnoma advance.  I have been essentially stable on Gleeved since March 2009. 

              I know one person that has the anal mucosal c-kit exon 11 mutation that had several recurances and then had the Yervoy immunotherapy treatments.  She had to go in the hospital twice, for a month each time, due to extremely bad side effects.  Her tumors did respond to the Yervoy.  She then developed brain tumors which were removed with SRS.

            • August 15, 2014 at 4:02 pm
            CHD
            Participant

              Thanks Jerry.  It sounds like you've had a great response to Gleevec!  The person I am thinking about doesn't have the BRAF or CKIT mutation, I don't know about NRAS.  It does get complicated with all the mutations – exciting though that it is making such a difference in treatment possibilities. 

              • August 15, 2014 at 4:02 pm
              CHD
              Participant

                Thanks Jerry.  It sounds like you've had a great response to Gleevec!  The person I am thinking about doesn't have the BRAF or CKIT mutation, I don't know about NRAS.  It does get complicated with all the mutations – exciting though that it is making such a difference in treatment possibilities. 

                • August 15, 2014 at 4:02 pm
                CHD
                Participant

                  Thanks Jerry.  It sounds like you've had a great response to Gleevec!  The person I am thinking about doesn't have the BRAF or CKIT mutation, I don't know about NRAS.  It does get complicated with all the mutations – exciting though that it is making such a difference in treatment possibilities. 

                • August 14, 2014 at 4:54 am
                JerryfromFauq
                Participant

                  I have not been able to find any statistics on Ipi (Yervoy) specific to any particular mutation.  Mucosal melanoma is not just one type.  My mucosal is C-kit.  The across the eboard response in around 20-25 % positive for all mutations lumped togeether.  The IL-2 immunotheropy was reported in Dec by the NIH to have a 47% positive response rate against NRAS melanoma mutations.  if one has the C-kit exon 11 mutation, Gleevec (Imatinb Mesylate) and others on that line (against other c-kit exon mutations) have recently been found to be an effective cytostatic treatment to often stop ones melnoma advance.  I have been essentially stable on Gleeved since March 2009. 

                      I know one person that has the anal mucosal c-kit exon 11 mutation that had several recurances and then had the Yervoy immunotherapy treatments.  She had to go in the hospital twice, for a month each time, due to extremely bad side effects.  Her tumors did respond to the Yervoy.  She then developed brain tumors which were removed with SRS.

                  • August 14, 2014 at 4:54 am
                  JerryfromFauq
                  Participant

                    I have not been able to find any statistics on Ipi (Yervoy) specific to any particular mutation.  Mucosal melanoma is not just one type.  My mucosal is C-kit.  The across the eboard response in around 20-25 % positive for all mutations lumped togeether.  The IL-2 immunotheropy was reported in Dec by the NIH to have a 47% positive response rate against NRAS melanoma mutations.  if one has the C-kit exon 11 mutation, Gleevec (Imatinb Mesylate) and others on that line (against other c-kit exon mutations) have recently been found to be an effective cytostatic treatment to often stop ones melnoma advance.  I have been essentially stable on Gleeved since March 2009. 

                        I know one person that has the anal mucosal c-kit exon 11 mutation that had several recurances and then had the Yervoy immunotherapy treatments.  She had to go in the hospital twice, for a month each time, due to extremely bad side effects.  Her tumors did respond to the Yervoy.  She then developed brain tumors which were removed with SRS.

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