Will he respond to antiPD1?

We have an appointment in 3 weeks, I will definitelly ask for an appointment.  I didn't think he can schedule it, I was under the impression it's a very specialized test, not available on the normal channels.

We have an appointment in 3 weeks, I will definitelly ask for an appointment.  I didn't think he can schedule it, I was under the impression it's a very specialized test, not available on the normal channels.

We have an appointment in 3 weeks, I will definitelly ask for an appointment.  I didn't think he can schedule it, I was under the impression it's a very specialized test, not available on the normal channels.

Thanks Jerry. 

Thanks Jerry. 

Thanks Jerry. 

I do not believe in statistics either, according to the initial dx my husband should have been dead last month.  He is still strong and I want to keep him this way.  I know antiPD1 is, at this point, the best option out there, but it's not the Holly Grail for everybody.  One thing I've learned about melanoma is how unpredictable it is.  The other one is the race against time.  If there's a way of telling if antiPD1 it's not going to work, and the test is reliable enough, then why not try something else first, like TIL, or another type of targeted terapy.  For now we're good, we can keep on taking the braf meds, hopefully he will respond for at least 1 year, and by then maybe another miracle treatment comes along.  But we need to be knoledgeable and prepared for any curved ball melanoma is going to throw at us.

I do not believe in statistics either, according to the initial dx my husband should have been dead last month.  He is still strong and I want to keep him this way.  I know antiPD1 is, at this point, the best option out there, but it's not the Holly Grail for everybody.  One thing I've learned about melanoma is how unpredictable it is.  The other one is the race against time.  If there's a way of telling if antiPD1 it's not going to work, and the test is reliable enough, then why not try something else first, like TIL, or another type of targeted terapy.  For now we're good, we can keep on taking the braf meds, hopefully he will respond for at least 1 year, and by then maybe another miracle treatment comes along.  But we need to be knoledgeable and prepared for any curved ball melanoma is going to throw at us.

Yes, he had tumour tissue harvested at the beginning of the trial but I was not aware I can ask for the results of the biopsy and BMS never volunteered.  We knew before we applied for the trial that hubs is Braf positive.  We have an appointment in two weeks and I will ask the dr.if hubs was tested for PDL1 expression, but to be perfectly onest I'm not sure how to use the information.  It's sad, but like Jerry said above (and confirmed from several sources), even without expressed PDL1  there is still a 17% chance it may work.  TIL has a 18% chance of success! but high toxicity and the targeted therapies even less.

I am highly anxious about all this situation.  On one hand we have a highly intelligent disease able to switch gears and adapt and go around treatments and invade and destroy all inside the body, and on the other hand we have a handful of treatments, none of them with more than 40% chance of success.  But despite the odds, we are not giving up, we keep the hope high, and we are ready to fight. 

Yes, he had tumour tissue harvested at the beginning of the trial but I was not aware I can ask for the results of the biopsy and BMS never volunteered.  We knew before we applied for the trial that hubs is Braf positive.  We have an appointment in two weeks and I will ask the dr.if hubs was tested for PDL1 expression, but to be perfectly onest I'm not sure how to use the information.  It's sad, but like Jerry said above (and confirmed from several sources), even without expressed PDL1  there is still a 17% chance it may work.  TIL has a 18% chance of success! but high toxicity and the targeted therapies even less.

I am highly anxious about all this situation.  On one hand we have a highly intelligent disease able to switch gears and adapt and go around treatments and invade and destroy all inside the body, and on the other hand we have a handful of treatments, none of them with more than 40% chance of success.  But despite the odds, we are not giving up, we keep the hope high, and we are ready to fight. 

Yes, he had tumour tissue harvested at the beginning of the trial but I was not aware I can ask for the results of the biopsy and BMS never volunteered.  We knew before we applied for the trial that hubs is Braf positive.  We have an appointment in two weeks and I will ask the dr.if hubs was tested for PDL1 expression, but to be perfectly onest I'm not sure how to use the information.  It's sad, but like Jerry said above (and confirmed from several sources), even without expressed PDL1  there is still a 17% chance it may work.  TIL has a 18% chance of success! but high toxicity and the targeted therapies even less.

I am highly anxious about all this situation.  On one hand we have a highly intelligent disease able to switch gears and adapt and go around treatments and invade and destroy all inside the body, and on the other hand we have a handful of treatments, none of them with more than 40% chance of success.  But despite the odds, we are not giving up, we keep the hope high, and we are ready to fight. 

I do not believe in statistics either, according to the initial dx my husband should have been dead last month.  He is still strong and I want to keep him this way.  I know antiPD1 is, at this point, the best option out there, but it's not the Holly Grail for everybody.  One thing I've learned about melanoma is how unpredictable it is.  The other one is the race against time.  If there's a way of telling if antiPD1 it's not going to work, and the test is reliable enough, then why not try something else first, like TIL, or another type of targeted terapy.  For now we're good, we can keep on taking the braf meds, hopefully he will respond for at least 1 year, and by then maybe another miracle treatment comes along.  But we need to be knoledgeable and prepared for any curved ball melanoma is going to throw at us.

I do not believe in statistics either, according to the initial dx my husband should have been dead last month.  He is still strong and I want to keep him this way.  I know antiPD1 is, at this point, the best option out there, but it's not the Holly Grail for everybody.  One thing I've learned about melanoma is how unpredictable it is.  The other one is the race against time.  If there's a way of telling if antiPD1 it's not going to work, and the test is reliable enough, then why not try something else first, like TIL, or another type of targeted terapy.  For now we're good, we can keep on taking the braf meds, hopefully he will respond for at least 1 year, and by then maybe another miracle treatment comes along.  But we need to be knoledgeable and prepared for any curved ball melanoma is going to throw at us.

I do not believe in statistics either, according to the initial dx my husband should have been dead last month.  He is still strong and I want to keep him this way.  I know antiPD1 is, at this point, the best option out there, but it's not the Holly Grail for everybody.  One thing I've learned about melanoma is how unpredictable it is.  The other one is the race against time.  If there's a way of telling if antiPD1 it's not going to work, and the test is reliable enough, then why not try something else first, like TIL, or another type of targeted terapy.  For now we're good, we can keep on taking the braf meds, hopefully he will respond for at least 1 year, and by then maybe another miracle treatment comes along.  But we need to be knoledgeable and prepared for any curved ball melanoma is going to throw at us.

I do not believe in statistics either, according to the initial dx my husband should have been dead last month.  He is still strong and I want to keep him this way.  I know antiPD1 is, at this point, the best option out there, but it's not the Holly Grail for everybody.  One thing I've learned about melanoma is how unpredictable it is.  The other one is the race against time.  If there's a way of telling if antiPD1 it's not going to work, and the test is reliable enough, then why not try something else first, like TIL, or another type of targeted terapy.  For now we're good, we can keep on taking the braf meds, hopefully he will respond for at least 1 year, and by then maybe another miracle treatment comes along.  But we need to be knoledgeable and prepared for any curved ball melanoma is going to throw at us.