› Forums › General Melanoma Community › помогите приобрести Дабрафениб (Tafinalar) и Траметиниб (Mekinist)!
- This topic has 21 replies, 4 voices, and was last updated 11 years, 7 months ago by
Osanna.
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- February 19, 2014 at 9:16 am
You can search for a clinical trial at Russia. There are several of them: http://www.clinicaltrials.gov/ct2/results?term=melanoma+russia&recr=Open
In a clinical trial the medicine is free.
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- February 19, 2014 at 9:16 am
You can search for a clinical trial at Russia. There are several of them: http://www.clinicaltrials.gov/ct2/results?term=melanoma+russia&recr=Open
In a clinical trial the medicine is free.
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- February 19, 2014 at 9:16 am
You can search for a clinical trial at Russia. There are several of them: http://www.clinicaltrials.gov/ct2/results?term=melanoma+russia&recr=Open
In a clinical trial the medicine is free.
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- February 19, 2014 at 12:53 pm
Google Translate translated this message as:
"I am from Russia. my dad is sick melanoma BRAF mutation V600R. metastases in the head and perirenal tissue of the kidney. it would be better zelboraf or tafinalar&mekinist???SOS!"
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Most people who have a BRAF mutation have either V600E or V600K mutations; V600R is very rare and we do not have much information about how the BRAF inhibitors work on V600R. However, a friend of mine has V600R and Zelboraf worked for him for a few months. Then he was able to start ipi and that worked, too. So I think a BRAF inhibitor might help your father.
Over time, most patients and doctors now think that taking a combination of BRAF+MEK works better than BRAF alone. In the US, the only MEK inhibitor that has been approved for use is Mekinist. Therefore, if you can get Tafinlar + Mekinist that would probably be best. Other BRAF and MEK inhibitor combinations are now in clinical trials that might be available in Russia.
If your father has brain (head) metastses, it is best to have those treated with radiation. If stereotactic radiosurgery (SRS) is possible, that is best. Otherwise, neurosurgery (with a scalpel) or whole brain radiation (WBR) is recommended.
I suggest that you also post this question on the Melanoma International Foundation forum at: http://forum.melanomainternational.org/mif/ They have a lot of members in Europe and they may know more about treatments and clinical trials available to your father.
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- February 19, 2014 at 12:53 pm
Google Translate translated this message as:
"I am from Russia. my dad is sick melanoma BRAF mutation V600R. metastases in the head and perirenal tissue of the kidney. it would be better zelboraf or tafinalar&mekinist???SOS!"
=========================================================
Most people who have a BRAF mutation have either V600E or V600K mutations; V600R is very rare and we do not have much information about how the BRAF inhibitors work on V600R. However, a friend of mine has V600R and Zelboraf worked for him for a few months. Then he was able to start ipi and that worked, too. So I think a BRAF inhibitor might help your father.
Over time, most patients and doctors now think that taking a combination of BRAF+MEK works better than BRAF alone. In the US, the only MEK inhibitor that has been approved for use is Mekinist. Therefore, if you can get Tafinlar + Mekinist that would probably be best. Other BRAF and MEK inhibitor combinations are now in clinical trials that might be available in Russia.
If your father has brain (head) metastses, it is best to have those treated with radiation. If stereotactic radiosurgery (SRS) is possible, that is best. Otherwise, neurosurgery (with a scalpel) or whole brain radiation (WBR) is recommended.
I suggest that you also post this question on the Melanoma International Foundation forum at: http://forum.melanomainternational.org/mif/ They have a lot of members in Europe and they may know more about treatments and clinical trials available to your father.
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- February 19, 2014 at 12:53 pm
Google Translate translated this message as:
"I am from Russia. my dad is sick melanoma BRAF mutation V600R. metastases in the head and perirenal tissue of the kidney. it would be better zelboraf or tafinalar&mekinist???SOS!"
=========================================================
Most people who have a BRAF mutation have either V600E or V600K mutations; V600R is very rare and we do not have much information about how the BRAF inhibitors work on V600R. However, a friend of mine has V600R and Zelboraf worked for him for a few months. Then he was able to start ipi and that worked, too. So I think a BRAF inhibitor might help your father.
Over time, most patients and doctors now think that taking a combination of BRAF+MEK works better than BRAF alone. In the US, the only MEK inhibitor that has been approved for use is Mekinist. Therefore, if you can get Tafinlar + Mekinist that would probably be best. Other BRAF and MEK inhibitor combinations are now in clinical trials that might be available in Russia.
If your father has brain (head) metastses, it is best to have those treated with radiation. If stereotactic radiosurgery (SRS) is possible, that is best. Otherwise, neurosurgery (with a scalpel) or whole brain radiation (WBR) is recommended.
I suggest that you also post this question on the Melanoma International Foundation forum at: http://forum.melanomainternational.org/mif/ They have a lot of members in Europe and they may know more about treatments and clinical trials available to your father.
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- February 20, 2014 at 12:59 pm
The link that Fortiz gave you to the clniicaltrials.gov web site listed clinical trials available in Russia (Fortiz already did that search for you). You should read through the clinical trials listed on that page because one or more of them might be good for your father.
Even if none of these clinical trials are good for your father, the places that offer clinical trials usually have doctors who know a lot about melanoma and how and where you can get the best medicines. Here is the list of places in Russia where there are now offering this clinical trial (for example): A Study of the BRAF Inhibitor Dabrafenib in Combination With the MEK Inhibitor Trametinib in the Adjuvant Treatment of High-risk BRAF V600 Mutation-positive Melanoma After Surgical Resection. (COMBI-AD) NCT01682083
Can you talk with a melanoma oncologist at one of these places to get more information about where to get Zelboraf or dabrafenib + mekininst treatments?
GSK Investigational Sites
Contact: EU GSK Clinical Trials Call Center
Phone: +44 (0) 20 8990 4466
Email: GSKClinicalSupportHD@gsk.com
Chelyabinsk, Russian Federation, 454087
Moscow, Russian Federation, 143423
Moscow, Russian Federation, 115478
Ryazan, Russian Federation, 390011
St. Petersburg, Russian Federation, 197758
St. Petersburg, Russian Federation, 191104
Volzhsky, Russian Federation, 404130
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- April 27, 2014 at 3:06 pm
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- April 27, 2014 at 3:06 pm
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- April 27, 2014 at 3:06 pm
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- February 20, 2014 at 12:59 pm
The link that Fortiz gave you to the clniicaltrials.gov web site listed clinical trials available in Russia (Fortiz already did that search for you). You should read through the clinical trials listed on that page because one or more of them might be good for your father.
Even if none of these clinical trials are good for your father, the places that offer clinical trials usually have doctors who know a lot about melanoma and how and where you can get the best medicines. Here is the list of places in Russia where there are now offering this clinical trial (for example): A Study of the BRAF Inhibitor Dabrafenib in Combination With the MEK Inhibitor Trametinib in the Adjuvant Treatment of High-risk BRAF V600 Mutation-positive Melanoma After Surgical Resection. (COMBI-AD) NCT01682083
Can you talk with a melanoma oncologist at one of these places to get more information about where to get Zelboraf or dabrafenib + mekininst treatments?
GSK Investigational Sites
Contact: EU GSK Clinical Trials Call Center
Phone: +44 (0) 20 8990 4466
Email: GSKClinicalSupportHD@gsk.com
Chelyabinsk, Russian Federation, 454087
Moscow, Russian Federation, 143423
Moscow, Russian Federation, 115478
Ryazan, Russian Federation, 390011
St. Petersburg, Russian Federation, 197758
St. Petersburg, Russian Federation, 191104
Volzhsky, Russian Federation, 404130
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- February 20, 2014 at 12:59 pm
The link that Fortiz gave you to the clniicaltrials.gov web site listed clinical trials available in Russia (Fortiz already did that search for you). You should read through the clinical trials listed on that page because one or more of them might be good for your father.
Even if none of these clinical trials are good for your father, the places that offer clinical trials usually have doctors who know a lot about melanoma and how and where you can get the best medicines. Here is the list of places in Russia where there are now offering this clinical trial (for example): A Study of the BRAF Inhibitor Dabrafenib in Combination With the MEK Inhibitor Trametinib in the Adjuvant Treatment of High-risk BRAF V600 Mutation-positive Melanoma After Surgical Resection. (COMBI-AD) NCT01682083
Can you talk with a melanoma oncologist at one of these places to get more information about where to get Zelboraf or dabrafenib + mekininst treatments?
GSK Investigational Sites
Contact: EU GSK Clinical Trials Call Center
Phone: +44 (0) 20 8990 4466
Email: GSKClinicalSupportHD@gsk.com
Chelyabinsk, Russian Federation, 454087
Moscow, Russian Federation, 143423
Moscow, Russian Federation, 115478
Ryazan, Russian Federation, 390011
St. Petersburg, Russian Federation, 197758
St. Petersburg, Russian Federation, 191104
Volzhsky, Russian Federation, 404130
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