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Stage IV–Need suggestions for further treatment

Forums General Melanoma Community Stage IV–Need suggestions for further treatment

  • Post
    kerstinmagnuson
    Participant

    My dad has stage IV melanoma with involvement in the brain, liver, and lungs. In Nov. 2011, he received the first diagnosis of melanoma from a node in his belly button. It hadn't spread at that point, but a scan in the summer of 2012 revealed melanoma in one lymph node. The nodes in that area were all removed, but in September 2012, a scan showed that the cancer had become metastatic and was in his liver, lungs, and brain. At first, he received Ippi treatments, which were ineffective. He then had a chemo cocktail of three agents, one of which was Avastin.

    My dad has stage IV melanoma with involvement in the brain, liver, and lungs. In Nov. 2011, he received the first diagnosis of melanoma from a node in his belly button. It hadn't spread at that point, but a scan in the summer of 2012 revealed melanoma in one lymph node. The nodes in that area were all removed, but in September 2012, a scan showed that the cancer had become metastatic and was in his liver, lungs, and brain. At first, he received Ippi treatments, which were ineffective. He then had a chemo cocktail of three agents, one of which was Avastin. That was only moderately effective. He also had gamma knife surgery and radiation for his brain tumors. In May, he entered an anti PD1 clinical trial, but was just taken out of it after a scan revealed tumor growth in his lungs and brain. He is supposed to start more chemo treatment again, including an oral chemo that is supposedly more effective against brain tumors. Does anyone have any suggestions of some other treatments we could try? We are open to trying anything that might help. Thanks! 

     

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  • Replies
      Johnfdc7
      Participant

      Hi Kerstin

      You dont mention whether your Dad's tumours have been tested for the BRAF mutation yet. I would expect this to have been done by now – if not, you should push to have it done.

      The BRAF drugs that are now approved appear to show some activity with brain mets both anedotally and in limited clinical trials.

      John

      Johnfdc7
      Participant

      Hi Kerstin

      You dont mention whether your Dad's tumours have been tested for the BRAF mutation yet. I would expect this to have been done by now – if not, you should push to have it done.

      The BRAF drugs that are now approved appear to show some activity with brain mets both anedotally and in limited clinical trials.

      John

      Johnfdc7
      Participant

      Hi Kerstin

      You dont mention whether your Dad's tumours have been tested for the BRAF mutation yet. I would expect this to have been done by now – if not, you should push to have it done.

      The BRAF drugs that are now approved appear to show some activity with brain mets both anedotally and in limited clinical trials.

      John

      JerryfromFauq
      Participant

      Is he elgible for ACT/TIL (NIH, MDA, ) ?

      JerryfromFauq
      Participant

      Is he elgible for ACT/TIL (NIH, MDA, ) ?

      JerryfromFauq
      Participant

      Is he elgible for ACT/TIL (NIH, MDA, ) ?

      kerstinmagnuson
      Participant
      He has been tested and he is BRAF negative. Thanks for the suggestion. We will check it out!
      Peabody_58
      Participant

      Pilot Ipilimumab in Stage IV Melanoma Receiving Palliative Radiation Therapy

      ClinicalTrials.gov Identifier:
      NCT01449279
       
      This may be a useful strategy.   I would also look at the PD-1 / Ipi combintation trials – there is one of these at Georgetown (Atkins) but there may be others around the country.
      There is always adoptive cell therapy (ACT), the subject of much debate here.  It is at least worth a phone call.
       
      Peabody_58
      Participant

      Pilot Ipilimumab in Stage IV Melanoma Receiving Palliative Radiation Therapy

      ClinicalTrials.gov Identifier:
      NCT01449279
       
      This may be a useful strategy.   I would also look at the PD-1 / Ipi combintation trials – there is one of these at Georgetown (Atkins) but there may be others around the country.
      There is always adoptive cell therapy (ACT), the subject of much debate here.  It is at least worth a phone call.
       
      Peabody_58
      Participant

      Pilot Ipilimumab in Stage IV Melanoma Receiving Palliative Radiation Therapy

      ClinicalTrials.gov Identifier:
      NCT01449279
       
      This may be a useful strategy.   I would also look at the PD-1 / Ipi combintation trials – there is one of these at Georgetown (Atkins) but there may be others around the country.
      There is always adoptive cell therapy (ACT), the subject of much debate here.  It is at least worth a phone call.
       
      kerstinmagnuson
      Participant
      He has been tested and he is BRAF negative. Thanks for the suggestion. We will check it out!
      kerstinmagnuson
      Participant
      He has been tested and he is BRAF negative. Thanks for the suggestion. We will check it out!
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