Bad News/Possible Good News. Help Needed Please
REGISTER
The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Content within the patient forum is user-generated and has not been reviewed by medical professionals. Other sections of the Melanoma Research Foundation website include information that has been reviewed by medical professionals as appropriate. All medical decisions should be made in consultation with your doctor or other qualified medical professional.

Bad News/Possible Good News. Help Needed Please

› Forums › General Melanoma Community › Bad News/Possible Good News. Help Needed Please

  • Post
    • June 6, 2013 at 1:57 am
    NYKaren
    Participant
    So Dr. Wolchok just called to tell me the Merck Phase 1 PD1 trial I was aiming for has been closed by Merck–or at least they’ve closed seats at sloan. He said it was Merck’s edict with no exceptions. Boy am I upset.
    He said my 2 choices are to go back on Zel or see Dr. Pavlick at NYU where they have seats in the phase 2 trial w/the chemo arm.
    I choose to at least see Dr P next week and see what she thinks. I know she’s good, it’s not a matter of that, it’s whether I want to possibly go through the effects of chemo. But I’m afraid if I go back on Zel, the Mel will just come back soon, when there might not be a trial seat available.

    Any ideas, thoughts, suggestions??
    🙁
    Karen

Viewing 8 reply threads
  • Replies
      • June 6, 2013 at 3:23 am
      kylez
      Participant

      Hi Karen,

      If the phase 2 trial with Dr. Pavlick is the same MK-3475 trial Catherine Poole has discussed over on MIF, (I think it must be), she said it's a 2:1 ration of MK-3475 arm vs. chemo arm, AND that there's some kind of crossover from chemo to MK-3475 if someone is not responding on chemo.

      Hope that helps some.

      – Kyle 

      • June 6, 2013 at 3:23 am
      kylez
      Participant

      Hi Karen,

      If the phase 2 trial with Dr. Pavlick is the same MK-3475 trial Catherine Poole has discussed over on MIF, (I think it must be), she said it's a 2:1 ration of MK-3475 arm vs. chemo arm, AND that there's some kind of crossover from chemo to MK-3475 if someone is not responding on chemo.

      Hope that helps some.

      – Kyle 

      • June 6, 2013 at 3:23 am
      kylez
      Participant

      Hi Karen,

      If the phase 2 trial with Dr. Pavlick is the same MK-3475 trial Catherine Poole has discussed over on MIF, (I think it must be), she said it's a 2:1 ration of MK-3475 arm vs. chemo arm, AND that there's some kind of crossover from chemo to MK-3475 if someone is not responding on chemo.

      Hope that helps some.

      – Kyle 

      • June 6, 2013 at 3:44 am
      POW
      Participant

      O-O-O-F-F-F! What a kick in the stomach! I can't believe the lousy luck you have had with getting into an anti-PD1 trial. I'm so sorry for your disappointment.

      As Kyle said, Catherine Poole at the Melanoma International Foundation keeps really close tabs on all the anti-PD1 trials. She always welcomes people to email her with specific questions. Her email is: cpoole@melanomainternational.org 

      Don't give up! You are worth the effort!

      • June 6, 2013 at 3:44 am
      POW
      Participant

      O-O-O-F-F-F! What a kick in the stomach! I can't believe the lousy luck you have had with getting into an anti-PD1 trial. I'm so sorry for your disappointment.

      As Kyle said, Catherine Poole at the Melanoma International Foundation keeps really close tabs on all the anti-PD1 trials. She always welcomes people to email her with specific questions. Her email is: cpoole@melanomainternational.org 

      Don't give up! You are worth the effort!

      • June 6, 2013 at 3:44 am
      POW
      Participant

      O-O-O-F-F-F! What a kick in the stomach! I can't believe the lousy luck you have had with getting into an anti-PD1 trial. I'm so sorry for your disappointment.

      As Kyle said, Catherine Poole at the Melanoma International Foundation keeps really close tabs on all the anti-PD1 trials. She always welcomes people to email her with specific questions. Her email is: cpoole@melanomainternational.org 

      Don't give up! You are worth the effort!

      • June 7, 2013 at 1:18 am
      jag
      Participant

      Oh Karen, I am very sorry to hear this.  Is it possible that there are still openings at the other locations?

      Whatever you decide, You are in my prayers.

      John

      http://www.clinicaltrials.gov/ct2/show/NCT01621490?term=melanoma+anti+pd1&rank=2

      • June 7, 2013 at 1:18 am
      jag
      Participant

      Oh Karen, I am very sorry to hear this.  Is it possible that there are still openings at the other locations?

      Whatever you decide, You are in my prayers.

      John

      http://www.clinicaltrials.gov/ct2/show/NCT01621490?term=melanoma+anti+pd1&rank=2

      • June 7, 2013 at 1:18 am
      jag
      Participant

      Oh Karen, I am very sorry to hear this.  Is it possible that there are still openings at the other locations?

      Whatever you decide, You are in my prayers.

      John

      http://www.clinicaltrials.gov/ct2/show/NCT01621490?term=melanoma+anti+pd1&rank=2

      • June 7, 2013 at 7:25 pm
      NYKaren
      Participant
      Thanks guys,
      Kyle, I think the crossover is allowed at 12 weeks… This stuff is growing fast. I will ask Dr. Pavlick (appt Monday afternoon–that’s impressive) what happens if it is seen to be progressing before then.

      John, BMS trial excludes prior Remicade use– the stuff that saved me during Ipi-induced colitis.

      I’ll post after I see Dr. P.
      have a good weekend all.
      Karen

      • June 7, 2013 at 7:25 pm
      NYKaren
      Participant
      Thanks guys,
      Kyle, I think the crossover is allowed at 12 weeks… This stuff is growing fast. I will ask Dr. Pavlick (appt Monday afternoon–that’s impressive) what happens if it is seen to be progressing before then.

      John, BMS trial excludes prior Remicade use– the stuff that saved me during Ipi-induced colitis.

      I’ll post after I see Dr. P.
      have a good weekend all.
      Karen

      • June 7, 2013 at 7:25 pm
      NYKaren
      Participant
      Thanks guys,
      Kyle, I think the crossover is allowed at 12 weeks… This stuff is growing fast. I will ask Dr. Pavlick (appt Monday afternoon–that’s impressive) what happens if it is seen to be progressing before then.

      John, BMS trial excludes prior Remicade use– the stuff that saved me during Ipi-induced colitis.

      I’ll post after I see Dr. P.
      have a good weekend all.
      Karen

Viewing 8 reply threads
  • You must be logged in to reply to this topic.
About the MRF Patient Forum

The MRF Patient Forum is the oldest and largest online community of people affected by melanoma. It is designed to provide peer support and information to caregivers, patients, family and friends. There is no better place to discuss different parts of your journey with this cancer and find the friends and support resources to make that journey more bearable.

The information on the forum is open and accessible to everyone. To add a new topic or to post a reply, you must be a registered user. Please note that you will be able to post both topics and replies anonymously even though you are logged in. All posts must abide by MRF posting policies.

Popular Topics