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2 new Genes discovered, an interesting discovery.

This topic has 6 replies, 2 voices, and was last updated 14 years, 1 month ago by bcl.

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- October 10, 2011 at 7:57 am
- Quote
James from Sydney
Participant

Researchers find 2 new Genes which might one day assist us in predicting the risk of getting Melanoma.

http://theconversation.edu.au/understanding-the-genetic-basis-of-melanoma-3756

Researchers find 2 new Genes which might one day assist us in predicting the risk of getting Melanoma.

http://theconversation.edu.au/understanding-the-genetic-basis-of-melanoma-3756

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Replies

- - October 12, 2011 at 11:02 pm
  - Quote
  JerryfromFauq
  Participant
  
  Went to the article. What are the 2 new Genes which might one day assist us in predicting the risk of getting Melanoma?
- - October 12, 2011 at 11:02 pm
  - Quote
  JerryfromFauq
  Participant
  
  Went to the article. What are the 2 new Genes which might one day assist us in predicting the risk of getting Melanoma?
  - October 13, 2011 at 12:16 am
    
    Quote
    bcl
    Participant
    
    Hi Jerry – I was looking for more details too and found these links online, not sure if it is the right info or not though..
    
    http://www.natureasia.com/en/highlights/details.php?id=1479
    
    Research Journal Highlights
    
    Variants associated with melanoma risk
    
    Nature Genetics, October 10, 2011
    
    Four melanoma susceptibility loci are reported in two studies published online this weekin Nature Genetics.Melanoma is a form of skin cancer that arises in melanocytes, which are cells that produce pigment. Worldwide, there are approximately 160,000 new cases of melanoma and 48,000 deaths from melanoma every year.
    
    David Bishop, Stuart Macgregor and their respective colleagues conducted independent genome-wide association studies and together identified four genetic regions that are associated with susceptibility to melanoma. David Bishop and colleagues analyzed the genomes of a few thousand individuals with melanoma and identified genetic risk loci at chromosomes 2, 11 and 21. Stuart Macgregor and colleagues also performed a genome-wide scan on a few thousand individuals with melanoma and discovered a genetic risk locus on chromosome 1.
    
    http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.959.html
    
    Nature Genetics | Letter
    
    Genome-wide association study identifies three new melanoma susceptibility loci
    
    We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control individuals of European ancestry, as well as an additional 6,426 control subjects from French or British populations, all of whom were genotyped for 317,000 or 610,000 single-nucleotide polymorphisms (SNPs). Our analysis replicated previously known melanoma susceptibility loci. Seven new regions with at least one SNP with P < 10⁻⁵ and further local imputed or genotyped support were selected for replication using two other genome-wide studies (from Australia and Texas, USA). Additional replication came from case-control series from the UK and The Netherlands. Variants at three of the seven loci replicated at P < 10⁻³: an SNP in ATM (rs1801516, overall P = 3.4 × 10⁻⁹), an SNP in MX2 (rs45430, P = 2.9 × 10⁻⁹) and an SNP adjacent to CASP8 (rs13016963, P = 8.6 × 10⁻¹⁰). A fourth locus near CCND1 remains of potential interest, showing suggestive but inconclusive evidence of replication (rs1485993, overall P = 4.6 × 10⁻⁷ under a fixed-effects model and P = 1.2 × 10⁻³ under a random-effects model). These newly associated variants showed no association with nevus or pigmentation phenotypes in a large British case-control series.
  - October 13, 2011 at 12:16 am
    
    Quote
    bcl
    Participant
    
    Hi Jerry – I was looking for more details too and found these links online, not sure if it is the right info or not though..
    
    http://www.natureasia.com/en/highlights/details.php?id=1479
    
    Research Journal Highlights
    
    Variants associated with melanoma risk
    
    Nature Genetics, October 10, 2011
    
    Four melanoma susceptibility loci are reported in two studies published online this weekin Nature Genetics.Melanoma is a form of skin cancer that arises in melanocytes, which are cells that produce pigment. Worldwide, there are approximately 160,000 new cases of melanoma and 48,000 deaths from melanoma every year.
    
    David Bishop, Stuart Macgregor and their respective colleagues conducted independent genome-wide association studies and together identified four genetic regions that are associated with susceptibility to melanoma. David Bishop and colleagues analyzed the genomes of a few thousand individuals with melanoma and identified genetic risk loci at chromosomes 2, 11 and 21. Stuart Macgregor and colleagues also performed a genome-wide scan on a few thousand individuals with melanoma and discovered a genetic risk locus on chromosome 1.
    
    http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.959.html
    
    Nature Genetics | Letter
    
    Genome-wide association study identifies three new melanoma susceptibility loci
    
    We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control individuals of European ancestry, as well as an additional 6,426 control subjects from French or British populations, all of whom were genotyped for 317,000 or 610,000 single-nucleotide polymorphisms (SNPs). Our analysis replicated previously known melanoma susceptibility loci. Seven new regions with at least one SNP with P < 10⁻⁵ and further local imputed or genotyped support were selected for replication using two other genome-wide studies (from Australia and Texas, USA). Additional replication came from case-control series from the UK and The Netherlands. Variants at three of the seven loci replicated at P < 10⁻³: an SNP in ATM (rs1801516, overall P = 3.4 × 10⁻⁹), an SNP in MX2 (rs45430, P = 2.9 × 10⁻⁹) and an SNP adjacent to CASP8 (rs13016963, P = 8.6 × 10⁻¹⁰). A fourth locus near CCND1 remains of potential interest, showing suggestive but inconclusive evidence of replication (rs1485993, overall P = 4.6 × 10⁻⁷ under a fixed-effects model and P = 1.2 × 10⁻³ under a random-effects model). These newly associated variants showed no association with nevus or pigmentation phenotypes in a large British case-control series.
  - October 13, 2011 at 12:16 am
    
    Quote
    bcl
    Participant
    
    Hi Jerry – I was looking for more details too and found these links online, not sure if it is the right info or not though..
    
    http://www.natureasia.com/en/highlights/details.php?id=1479
    
    Research Journal Highlights
    
    Variants associated with melanoma risk
    
    Nature Genetics, October 10, 2011
    
    Four melanoma susceptibility loci are reported in two studies published online this weekin Nature Genetics.Melanoma is a form of skin cancer that arises in melanocytes, which are cells that produce pigment. Worldwide, there are approximately 160,000 new cases of melanoma and 48,000 deaths from melanoma every year.
    
    David Bishop, Stuart Macgregor and their respective colleagues conducted independent genome-wide association studies and together identified four genetic regions that are associated with susceptibility to melanoma. David Bishop and colleagues analyzed the genomes of a few thousand individuals with melanoma and identified genetic risk loci at chromosomes 2, 11 and 21. Stuart Macgregor and colleagues also performed a genome-wide scan on a few thousand individuals with melanoma and discovered a genetic risk locus on chromosome 1.
    
    http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.959.html
    
    Nature Genetics | Letter
    
    Genome-wide association study identifies three new melanoma susceptibility loci
    
    We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control individuals of European ancestry, as well as an additional 6,426 control subjects from French or British populations, all of whom were genotyped for 317,000 or 610,000 single-nucleotide polymorphisms (SNPs). Our analysis replicated previously known melanoma susceptibility loci. Seven new regions with at least one SNP with P < 10⁻⁵ and further local imputed or genotyped support were selected for replication using two other genome-wide studies (from Australia and Texas, USA). Additional replication came from case-control series from the UK and The Netherlands. Variants at three of the seven loci replicated at P < 10⁻³: an SNP in ATM (rs1801516, overall P = 3.4 × 10⁻⁹), an SNP in MX2 (rs45430, P = 2.9 × 10⁻⁹) and an SNP adjacent to CASP8 (rs13016963, P = 8.6 × 10⁻¹⁰). A fourth locus near CCND1 remains of potential interest, showing suggestive but inconclusive evidence of replication (rs1485993, overall P = 4.6 × 10⁻⁷ under a fixed-effects model and P = 1.2 × 10⁻³ under a random-effects model). These newly associated variants showed no association with nevus or pigmentation phenotypes in a large British case-control series.
- - October 12, 2011 at 11:02 pm
  - Quote
  JerryfromFauq
  Participant
  
  Went to the article. What are the 2 new Genes which might one day assist us in predicting the risk of getting Melanoma?

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