Possible cure?

This is very exciting!!!!

This is very exciting!!!!

This is very exciting!!!!

It's part of the virus based treatments going on. Other places are trying other types of viruses. Virus treatments are getting a lot of news probably because they are rather new and can have dramatic results. As far as a cure the data and time will tell. Apparently they have had a 60% response rate so far if I read into what they are saying with the anticipation of making it even better. So in my opinion that is already fantastic. Keytruda pd1 in the best trial arm I read had about 42% and the fda approved dose was 25% granted there are probably other data about it I haven't seen with different numbers.

So in my opinion getting that response rate with a fairly mild virus compared with some of the others like polio is fantastic. However it seems the patient must have surface lesions thus leaving out some patients. Plus those who have been on immunotherapy I wonder if this type of treatment could even work because we already have a boosted immune system so can this treatment even have a chance to work seems unknown. So really lots of unknowns but very exciting stuff.

Artie

It's part of the virus based treatments going on. Other places are trying other types of viruses. Virus treatments are getting a lot of news probably because they are rather new and can have dramatic results. As far as a cure the data and time will tell. Apparently they have had a 60% response rate so far if I read into what they are saying with the anticipation of making it even better. So in my opinion that is already fantastic. Keytruda pd1 in the best trial arm I read had about 42% and the fda approved dose was 25% granted there are probably other data about it I haven't seen with different numbers.

So in my opinion getting that response rate with a fairly mild virus compared with some of the others like polio is fantastic. However it seems the patient must have surface lesions thus leaving out some patients. Plus those who have been on immunotherapy I wonder if this type of treatment could even work because we already have a boosted immune system so can this treatment even have a chance to work seems unknown. So really lots of unknowns but very exciting stuff.

Artie

It's part of the virus based treatments going on. Other places are trying other types of viruses. Virus treatments are getting a lot of news probably because they are rather new and can have dramatic results. As far as a cure the data and time will tell. Apparently they have had a 60% response rate so far if I read into what they are saying with the anticipation of making it even better. So in my opinion that is already fantastic. Keytruda pd1 in the best trial arm I read had about 42% and the fda approved dose was 25% granted there are probably other data about it I haven't seen with different numbers.

So in my opinion getting that response rate with a fairly mild virus compared with some of the others like polio is fantastic. However it seems the patient must have surface lesions thus leaving out some patients. Plus those who have been on immunotherapy I wonder if this type of treatment could even work because we already have a boosted immune system so can this treatment even have a chance to work seems unknown. So really lots of unknowns but very exciting stuff.

Artie

Wow, 60% is huge! I did some googling and found a link to the trial at the Huntsman site: http://healthcare.utah.edu/huntsmancancerinstitute/clinical-trials/find-clinical-trials-at-hci/melanoma.php. According to it the trial combines ipi with a HSV-1 oncolytic virus. It does not appear the tumor must be presenting on the skin, just that it cannot be visceral. Looking at the elegibility criteria, it does say the patient must never have been on ipi.

I found the trial at the clinicaltrials.gov site (https://www.clinicaltrials.gov/ct2/show/NCT02272855) and it looks like there are multiple locations for the trial but that enrollment is limited to 43 patients (it is a phase 2 trial).

Wow, 60% is huge! I did some googling and found a link to the trial at the Huntsman site: http://healthcare.utah.edu/huntsmancancerinstitute/clinical-trials/find-clinical-trials-at-hci/melanoma.php. According to it the trial combines ipi with a HSV-1 oncolytic virus. It does not appear the tumor must be presenting on the skin, just that it cannot be visceral. Looking at the elegibility criteria, it does say the patient must never have been on ipi.

I found the trial at the clinicaltrials.gov site (https://www.clinicaltrials.gov/ct2/show/NCT02272855) and it looks like there are multiple locations for the trial but that enrollment is limited to 43 patients (it is a phase 2 trial).

Wow, 60% is huge! I did some googling and found a link to the trial at the Huntsman site: http://healthcare.utah.edu/huntsmancancerinstitute/clinical-trials/find-clinical-trials-at-hci/melanoma.php. According to it the trial combines ipi with a HSV-1 oncolytic virus. It does not appear the tumor must be presenting on the skin, just that it cannot be visceral. Looking at the elegibility criteria, it does say the patient must never have been on ipi.

I found the trial at the clinicaltrials.gov site (https://www.clinicaltrials.gov/ct2/show/NCT02272855) and it looks like there are multiple locations for the trial but that enrollment is limited to 43 patients (it is a phase 2 trial).

Rigvir is used in Europe to treat melanoma with some success. It is a virus also and has been around for years. It is not biologically engineered so it is very safe to use.

Not sure why it isnt used in US but vaccines seem the way forward far better than any of the toxic drugs that are currently being used to treat melanoma.

Rigvir is used in Europe to treat melanoma with some success. It is a virus also and has been around for years. It is not biologically engineered so it is very safe to use.

Not sure why it isnt used in US but vaccines seem the way forward far better than any of the toxic drugs that are currently being used to treat melanoma.

Rigvir is used in Europe to treat melanoma with some success. It is a virus also and has been around for years. It is not biologically engineered so it is very safe to use.

Not sure why it isnt used in US but vaccines seem the way forward far better than any of the toxic drugs that are currently being used to treat melanoma.