taron

This recent paper from Flaherty, Ribas and co. may explain why some people may get a second response to BRAF inhibitors http://http://www.ncbi.nlm.nih.gov/pubmed/22113612

Also we understood from Roche that at least in EU they may be open to accept patients – under certain conditions to be confirmed – to "reinduced" inside their EAP. 

Please discuss with your doctors as an option for patients who have already progressed on a BRAF iihibitor (either Roche or GSK).  For some – like for Quentin – this could be a lifeline when all other treatment options have been exhausted.  For the patients and research community this will accelerate the understanding of the mechanisms of resistence and hopefully the identification of ways around them.

Stay strong.

This recent paper from Flaherty, Ribas and co. may explain why some people may get a second response to BRAF inhibitors http://http://www.ncbi.nlm.nih.gov/pubmed/22113612

Also we understood from Roche that at least in EU they may be open to accept patients – under certain conditions to be confirmed – to "reinduced" inside their EAP. 

Please discuss with your doctors as an option for patients who have already progressed on a BRAF iihibitor (either Roche or GSK).  For some – like for Quentin – this could be a lifeline when all other treatment options have been exhausted.  For the patients and research community this will accelerate the understanding of the mechanisms of resistence and hopefully the identification of ways around them.

Stay strong.

This recent paper from Flaherty, Ribas and co. may explain why some people may get a second response to BRAF inhibitors http://http://www.ncbi.nlm.nih.gov/pubmed/22113612

Also we understood from Roche that at least in EU they may be open to accept patients – under certain conditions to be confirmed – to "reinduced" inside their EAP. 

Please discuss with your doctors as an option for patients who have already progressed on a BRAF iihibitor (either Roche or GSK).  For some – like for Quentin – this could be a lifeline when all other treatment options have been exhausted.  For the patients and research community this will accelerate the understanding of the mechanisms of resistence and hopefully the identification of ways around them.

Stay strong.

Hi boot2aboot and Lynn, 

The example in Belgium shows that at least for some, resistance may not genetic (since one would assume that it is highly unlikely your tumor mutates and therefore you develop resistance and then after w while you have a second mutation that brings you back exactly where you started).  I believe this is what is called epigenetics.

That said mine and other oncologysts also check for a new mutation upon resistance, which leads me to believe that there must be some evidence that for some, resistance can be explained genetically.

Since we are trailblazing, and nobody knows (including our dr's) what's necessarily the best option, I want to learn as much as possible and moreover I think we as patients can help the dr's community (and ourselves) by sharing patients cases before they are published – to maximise the chances that we will also benefit from that knowledge, not just those that come after.  The internet's speed must more useful than just to know what Jay-z is up to on twitter.

Hi boot2aboot and Lynn, 

The example in Belgium shows that at least for some, resistance may not genetic (since one would assume that it is highly unlikely your tumor mutates and therefore you develop resistance and then after w while you have a second mutation that brings you back exactly where you started).  I believe this is what is called epigenetics.

That said mine and other oncologysts also check for a new mutation upon resistance, which leads me to believe that there must be some evidence that for some, resistance can be explained genetically.

Since we are trailblazing, and nobody knows (including our dr's) what's necessarily the best option, I want to learn as much as possible and moreover I think we as patients can help the dr's community (and ourselves) by sharing patients cases before they are published – to maximise the chances that we will also benefit from that knowledge, not just those that come after.  The internet's speed must more useful than just to know what Jay-z is up to on twitter.

Hi boot2aboot and Lynn, 

The example in Belgium shows that at least for some, resistance may not genetic (since one would assume that it is highly unlikely your tumor mutates and therefore you develop resistance and then after w while you have a second mutation that brings you back exactly where you started).  I believe this is what is called epigenetics.

That said mine and other oncologysts also check for a new mutation upon resistance, which leads me to believe that there must be some evidence that for some, resistance can be explained genetically.

Since we are trailblazing, and nobody knows (including our dr's) what's necessarily the best option, I want to learn as much as possible and moreover I think we as patients can help the dr's community (and ourselves) by sharing patients cases before they are published – to maximise the chances that we will also benefit from that knowledge, not just those that come after.  The internet's speed must more useful than just to know what Jay-z is up to on twitter.

Hi boot2aboot and Lynn, 

The example in Belgium shows that at least for some, resistance may not genetic (since one would assume that it is highly unlikely your tumor mutates and therefore you develop resistance and then after w while you have a second mutation that brings you back exactly where you started).  I believe this is what is called epigenetics.

That said mine and other oncologysts also check for a new mutation upon resistance, which leads me to believe that there must be some evidence that for some, resistance can be explained genetically.

Since we are trailblazing, and nobody knows (including our dr's) what's necessarily the best option, I want to learn as much as possible and moreover I think we as patients can help the dr's community (and ourselves) by sharing patients cases before they are published – to maximise the chances that we will also benefit from that knowledge, not just those that come after.  The internet's speed must more useful than just to know what Jay-z is up to on twitter.

Hi boot2aboot and Lynn, 

The example in Belgium shows that at least for some, resistance may not genetic (since one would assume that it is highly unlikely your tumor mutates and therefore you develop resistance and then after w while you have a second mutation that brings you back exactly where you started).  I believe this is what is called epigenetics.

That said mine and other oncologysts also check for a new mutation upon resistance, which leads me to believe that there must be some evidence that for some, resistance can be explained genetically.

Since we are trailblazing, and nobody knows (including our dr's) what's necessarily the best option, I want to learn as much as possible and moreover I think we as patients can help the dr's community (and ourselves) by sharing patients cases before they are published – to maximise the chances that we will also benefit from that knowledge, not just those that come after.  The internet's speed must more useful than just to know what Jay-z is up to on twitter.

Hi boot2aboot and Lynn, 

The example in Belgium shows that at least for some, resistance may not genetic (since one would assume that it is highly unlikely your tumor mutates and therefore you develop resistance and then after w while you have a second mutation that brings you back exactly where you started).  I believe this is what is called epigenetics.

That said mine and other oncologysts also check for a new mutation upon resistance, which leads me to believe that there must be some evidence that for some, resistance can be explained genetically.

Since we are trailblazing, and nobody knows (including our dr's) what's necessarily the best option, I want to learn as much as possible and moreover I think we as patients can help the dr's community (and ourselves) by sharing patients cases before they are published – to maximise the chances that we will also benefit from that knowledge, not just those that come after.  The internet's speed must more useful than just to know what Jay-z is up to on twitter.